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research Screening of synthetic and natural product databases: Identification of novel androgens and antiandrogens

14 citations , November 2014 in “European journal of medicinal chemistry”

Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

research Subcellular localization of the five members of the human steroid 5α-reductase family

13 citations , June 2017 in “Biochimie open”

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

research Sex differences in the effect of finasteride on acute ethanol withdrawal severity in mice : thesis

January 2006

Finasteride worsens alcohol withdrawal in female mice but eases it in male mice.

research Frizzled Receptors in Development and Disease

114 citations , January 2016 in “Current topics in developmental biology/Current Topics in Developmental Biology”

Frizzled receptors are essential for various body development processes and maintaining certain body functions.

research Structural Requirements of Minoxidil Analogs for Enhancing Lysyl Hydroxylase Inhibitory Activity

April 2012 in “KSBB Journal”

Minoxidil analogs can be improved for hair growth inhibition by modifying specific parts of their structure.

research Structural Characterization and Ligand Specific Protein Interactions of Androgen Receptor

March 2008 in “The Knowledge Bank (The Ohio State University)”

SARM-induced changes in the androgen receptor are specific to each ligand and affect stability and protein interactions.

Anxiety and Depression-Like Behaviour Following Short-Term Finasteride Administration Is Associated With Impaired Synaptic Plasticity and Cognitive Behaviour in Male Rats

research Anxiety-, and Depression-like Behaviour Following Short-Term Finasteride Administration is Associated with Impaired Synaptic Plasticity and Cognitive Behaviour in Male Rats

April 2024 in “Journal of psychiatric research”

Short-term finasteride use in male rats caused anxiety, depression, and memory problems.

research Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids

November 2023

New steroid derivatives show promise as anticancer agents, even against resistant cells.

research Synthesis of N-Substituted 3-Oxo-17b- carboxamide-4-aza-5a-androstanes and the Tautomerism of 3-Oxo-4-aza-5-androstenes

4 citations , January 1998 in “Heterocycles”

Researchers made two new compounds that could be used for medicine.

research Synthesis and Study of Some 17a-aza-D-homo Steroids as 5α-Reductase Inhibitors

1 citations , October 2020 in “Current Drug Discovery Technologies”

The research found that compound 6, a newly created steroid, is more effective at inhibiting 5α-reductase (an enzyme) than current treatments, suggesting it could be a better option for treating urinary tract symptoms in men.

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