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research Quantification of biotin in plasma samples by column switching liquid chromatography – tandem mass spectrometry
The document describes a way to measure biotin in blood to prevent wrong test results in hormone level testing.
research Preparation of3H-labelled testosterone metabolites
The conclusion is that tritium-labeled testosterone metabolites can be made and are better converted into dihydrotestosterone in skin cells than in prostate tissue.
research Androgen receptor in rat liver: Characterization and separation from a male-specific estrogen-binding protein
Male rats have androgen receptors in their liver, which are different from proteins that bind estrogen.
research Protein deprivation: comparative response of hair roots, serum protein, and urinary nitrogen
Lack of protein causes hair root damage, but it can be reversed by eating protein again.
research Enhanced ex vivo skin retention of bicalutamide using a nano-in-micro composite: Drug-loaded lipid vesicles in a dissolving microarray patch
The new drug delivery system improves bicalutamide skin retention for better treatment of hair loss.
research In vitro bioassays for androgens and their diagnostic applications
In vitro bioassays are better than traditional methods for measuring androgen activity but aren't ready for routine use yet.
research Advances in structure-based drug design targeting membrane protein markers in prostate cancer
Computational methods help design drugs targeting prostate cancer proteins.
research Neonatal screening in Sweden and disease-causing variants in phenylketonuria, galactosaemia and biotinidase deficiency
The Swedish neonatal screening program effectively detects PKU, galactosaemia, and biotinidase deficiency with low false positives.
research In Vitroandin VivoStructure-Activity Relationships of Novel Androgen Receptor Ligands with Multiple Substituents in the B-Ring
Certain changes to the B-ring of androgen receptor ligands can increase their effectiveness for potential treatments of muscle and bone conditions.
research Protein Carbonylation as a Reliable Read-Out of Urban Pollution Damage/Protection of Hair Fibers
research Vitamin D and the Parenteral Nutrition Patient
Vitamin D is crucial for bone health and preventing serious diseases.
research Biochemical approach on the conservation of drug molecules during hair fiber formation
Drugs can be incorporated into hair based on their chemical properties and hair pigmentation.
research The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function
A protein called CBP is found in prostate cancer and can increase the effectiveness of certain prostate cancer treatments.
research Characterization of Soluble Protein Extracts from Keratinized Tissues: identification of Ubiquitin Universally Distributed in Hair, Nail, and Stratum Corneum
Ubiquitin, a protein, is found in hair, nails, and skin.
research THE WATER SOLUBLE VITAMINS
Choline and biotin are important for liver health and preventing certain deficiencies in animals, and more research is needed to understand their benefits in humans.
research Proteolysis‐Targeting Chimera (PROTAC): Current Applications and Future Directions
PROTACs offer new ways to treat hard-to-target diseases, with promising drugs for cancer in advanced trials.
research Identification of Anabolic Selective Androgen Receptor Modulators with Reduced Activities in Reproductive Tissues and Sebaceous Glands
Two new compounds were found to build bone and muscle without affecting reproductive organs and skin oil glands.
research Homology Modeling of 5-alpha-Reductase 2 Using Available Experimental Data
Accurate protein modeling can help develop new treatments for prostate cancer and other diseases.
research The Role of Paracellular Transport in the Intestinal Absorption and Biopharmaceutical Characterization of Minoxidil
research Bioequivalence of finasteride tablets in healthy volunteers
Two types of finasteride tablets work the same in the body.
research Design, Synthesis, and Preclinical Evaluation of Prostate-Specific Membrane Antigen Targeted 99mTc-Radioimaging Agents
Researchers developed promising agents for prostate cancer imaging, with the best one showing high potential for clinical use.
research Production of biologically active oxidized derivatives of finasteride through metabolism byAspergillus nigerculture
Aspergillus niger culture creates two finasteride derivatives with enzyme-inhibiting effects.
research Identification of hydroxylated and glucuronidated metabolites of finasteride in human bile and urine
Finasteride is extensively metabolized in the body, affecting its effectiveness and safety.
research Investigations on the penetration of hydrolyzed wheat proteins into human hair by confocal laser-scanning fluorescence microscopy
Hydrolyzed wheat proteins penetrate all hair types effectively.
research BIO-ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF FINASTERIDE, TADALAFIL, AND ITS APPLICATION TO PHARMACOKINETIC STUDIES IN RAT PLASMA BY USING LC-MS/MS
A reliable method was developed to measure Finasteride and Tadalafil in rat blood.
research Determination of finasteride by HPLC-MS and study its pharmacokinetics
A new method accurately measures finasteride levels in blood and shows how the body processes it.
research Biotin deficiency complicating parenteral alimentation: Diagnosis, metabolic repercussions, and treatment
Biotin deficiency in patients on total parenteral nutrition can cause serious symptoms but can be treated with biotin supplements.
research In vivo Pharmacokinetic Interactions of Finasteride and Identification of Novel Metabolites
Finasteride is mainly broken down by the enzyme CYP3A4, affecting its levels in the body.
research Ionizable Coenzyme‐Engineered Lipid/Fiber Microplexes Boost Ribosomal Translation to Improve mRNA Therapy for Degenerative Diseases
New lipid/fiber microplexes improve mRNA therapy for degenerative diseases by enhancing cell function and treatment effectiveness.