research stem cell translation and bioethics
The document concludes that stem cell therapies lack solid proof of effectiveness, except for blood system treatments, and criticizes the ethical issues and commercial exploitation in the field.
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600-630 / 1000+ results research Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020
Platelet-rich plasma shows promise in healing and treating musculoskeletal issues, but translating lab results to human treatments is challenging.
research 576 INTASYL PH-762: Intratumoral immunotherapy targeting PD-1
PH-762 shows promise in treating skin cancer by effectively targeting and silencing PD-1 in tumors with minimal side effects.
research Self-microemulsifying systems of Finasteride with enhanced oral bioavailability: multivariate statistical evaluation, characterization, spray-drying and in vivo studies in human volunteers
Improved Finasteride delivery for hair loss treatment.
research Determination of finasteride in human plasma by liquid chromatography–electrospray ionization tandem mass spectrometry with flow rate gradient
Researchers developed a quick and sensitive way to measure finasteride in blood using a small sample size.
research Development of Fast Reverse Phase Liquid Chromatographic Method for Simultaneous Analysis of Betamethasone Dipropionate and Calcipotriol in Ointments and Bulk Drug
Researchers developed a quick and reliable method to test for betamethasone dipropionate and calcipotriol in ointments and drugs.
research 3D Bioprinting for Engineered Tissue Constructs and Patient‐Specific Models: Current Progress and Prospects in Clinical Applications
Bioprinting is advancing towards creating personalized tissues and organs, but challenges remain for clinical use.
research Clinical and analytical evaluation of LC-MS methods for plasma renin activity and aldosterone
The study developed methods to measure biomarkers in mice and found differences in hormone levels linked to gut microbiota diversity and stress response.
research Regulatory, Ethical, and Safety Considerations of Exosome‐Based Therapies in Dermatology
Exosome-based therapies show promise for regenerative applications in dermatology, including skin rejuvenation, wound healing, and hair restoration. However, these therapies face significant challenges due to variability in cell sourcing, manufacturing, and product characterization, complicating standardization and regulation. No exosome-based products have received FDA approval for dermatologic use, and there are concerns about adverse reactions and limited long-term safety data. The study emphasizes the need for regulatory literacy, transparent informed consent, structured product evaluation, and evidence-based clinical restraint to ensure patient safety as these therapies are integrated into clinical practice.
research MP-09.08
The study found that different criteria led to different patient groups in the CombAT study compared to the MTOPS study.
research Recent Advances in Peptide Drug Discovery: Novel Strategies and Targeted Protein Degradation
Peptide drugs now target hard-to-reach proteins more effectively and specifically.
research PRP, Exosomes, and Stem Cells: An International Perspective
More research and collaboration are needed to effectively use PRP, stem cells, and exosomes in medicine.
research Study on Bioequivalence of Finasteride Tablets in Human Body
Domestic and imported finasteride tablets work the same in the body.
research Candidate SNP markers of reproductive potential are predicted by a significant change in the affinity of TATA-binding protein for human gene promoters
Certain genetic markers linked to reproductive potential were identified by their impact on a protein's ability to bind to genes.
research Simultaneous pharmacokinetic and pharmacodynamic analysis of 5α-reductase inhibitors and androgens by liquid chromatography tandem mass spectrometry
The method effectively measures drug impact on DHT levels in prostate treatments.
research Application of 3D Bioprinting Technology for Tissue Regeneration, Drug Evaluation, and Drug Delivery
3D bioprinting is useful for making tissues, testing drugs, and delivering drugs, but needs better materials, resolution, and scalability.
research From bench to babies – drug development for male subfertility
New methods may speed up drug development for male subfertility.
research Peptide-based Biomaterials
Peptides are being used to create biomaterials that can help diagnose and treat diseases.
research When two plus two must not equal four
Regulatory challenges make developing combination therapies in urology difficult and costly.
research Advances in Bioprinting to Model Immune‐Mediated Skin Diseases
Bioprinting is improving skin models for better testing of skin diseases without using animals.
research Dermatologic research techniques
Various techniques help study skin conditions and test drug effects.
research Utilização de plaquetas e de produtos derivados de plaquetas humanas em terapias avançadas
Platelets and their derivatives, like PRP, can help tissue regeneration, but need standardized safety protocols.
research Preparing regenerative therapies for clinical application: proposals for responsible translation
The document suggests a need for collaboration, better evidence, and a responsible framework to safely and effectively advance regenerative therapies to clinical use.
research Determination of finasteride in human plasma by liquid–liquid extraction and high-performance liquid chromatography
Valid method measures finasteride in plasma, simple, fast, and affordable.
research Cardiac biopsy in myocarditis
Some people have a genetic variation that makes them less effective at breaking down drugs.
research Disease-related biomarkers as experimental endpoints in 3D skin culture models
research 484 FDA cleared devices produce inconsistent platelet-rich plasma product
FDA-cleared devices often fail to produce high-quality platelet-rich plasma consistently.
research Phytochemicals and Nano-Phytopharmaceuticals Use in Skin, Urogenital and Locomotor Disorders: Are We There?
Nano-phytopharmaceuticals show promise but need more research for safe, effective use in treating certain disorders.
research Sulfatase inhibitors: a patent review
The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.
research Pharmaceutical nanotechnology in Egypt: diverse applications and promising outcomes
Egyptian researchers are advancing in pharmaceutical nanotechnology, potentially improving health outcomes and the economy.