research Gender-Affirming Hormone Therapy for Transgender Females
Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.
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research Expression of 11β-hydroxysteroid dehydrogenase type 1 in visceral and subcutaneous adipose tissues of patients with polycystic ovary syndrome is associated with adiposity
Increased HSD11B1 enzyme expression is linked to higher body fat and insulin resistance.
research The Aging Face
Facial aging is caused by natural processes and external factors, and can be managed with preventative measures and a variety of treatments tailored to individual needs.
research Effect of a low-starch/low-dairy diet on fat oxidation in overweight and obese women with polycystic ovary syndrome
A low-starch/low-dairy diet may help overweight women with PCOS lose weight and improve metabolism, but more research is needed.
research Facial Appearance and Markers of Cardiometabolic Risk in Healthy Adult Men
Men's facial appearance shows age, body fat, and testosterone levels, not metabolic health.
research Author response: Effects of lifelong testosterone exposure on health and disease using Mendelian randomization
Long-term high testosterone levels can improve bone density and reduce body fat but may increase the risk of prostate cancer and high blood pressure.
research Decision letter: Effects of lifelong testosterone exposure on health and disease using Mendelian randomization
Increased free testosterone can lead to stronger bones and less body fat but also higher risks of prostate cancer, hair loss, spine issues, and high blood pressure.
research Affect of a six months treatment regiment of metformin (MET) on 17-hydroxyprogesterone (17P) responses to GnRH agonist (GnRH Ag) in polycystic ovary syndrome (PCOS)
Metformin can start ovulation and may lower 17P response in PCOS, but six months is too short to improve hair growth or change body fat distribution.
research Mesotherapy for local fat reduction
Mesotherapy might help reduce fat in specific areas for those close to their ideal weight, but more research and care are needed to ensure safety.
research “You Need a Makeover!”: The Social Construction of Female Body Image in “A Makeover Story”, W “hat Not to Wear”, and “Extreme Makeover”
Makeover TV shows promote unrealistic beauty standards and pressure women to conform to societal ideals.
research The Pathophysiology of the Male Aging Face and Body
Aging in men is influenced by genetics and lifestyle, leading to muscle loss, bone issues, and skin damage.
research Chronic inflammatory diseases are stimulated by current lifestyle: how diet, stress levels and medication prevent our body from recovering
Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.
research Transmasculine Hormone Therapy
Testosterone therapy for transmasculine individuals is generally safe with medical supervision, improves mental health, and has mixed effects on physical health.
research Benign prostatic hyperplasia, metabolic syndrome and androgenic alopecia: Is there a possible relationship?
People with early hair loss may have a higher chance of enlarged prostate and metabolic syndrome, so they should be checked for urinary and metabolic issues.
research Cutaneous Toxicities From Transplantation-Related Medications
Skin problems from transplant drugs are common and need careful management in organ transplant patients.
research Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome
Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.
research Skin aging as a mechanical phenomenon: The main weak links
Skin aging is largely due to differences in stiffness and elasticity between skin layers, leading to wrinkles.
research Rodent models in placental research. Implications for fetal origins of adult disease
Using rodents for research shows that health problems in the womb can cause diseases later in life.
research Hair growth promoting effect of dermal papilla like tissues from canine adipose-derived mesenchymal stem cells through vascular endothelial growth factor
Lab-made tissues from dog fat stem cells can help grow hair by releasing a growth factor.
research The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion
ARL15 is important for fat cell development and the release of the hormone adiponectin.
research Recent advances in the molecular mechanisms determining tissue sensitivity to glucocorticoids: novel mutations, circadian rhythm and ligand-induced repression of the human glucocorticoid receptor
New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.
research Squarticles as the nanoantidotes to sequester the overdosed antidepressant for detoxification
Tiny particles called anionic squarticles can effectively remove a common antidepressant from the body after an overdose.
research Journal Watch
A test for nail fungus was most accurate with PAS stain, low-dose spironolactone helped two-thirds of acne patients, metformin reduced symptoms of HIV-related fat distribution changes with some side effects, and skin examination with dermoscopy was better at detecting abnormal moles, while temporary tattoos can cause skin reactions.
research A systematic review of antiandrogens and feminization in transgender women
Some antiandrogens may lower testosterone better than others, but it's unclear which is best for feminization in transgender women; more research is needed.
research Dermatological considerations for transgender and gender diverse patients: An Australian perspective
Dermatologists are essential in helping transgender and gender diverse patients with skin and hair issues related to gender affirmation and hormone therapy.
research Risks for metabolic syndrome and cardiovascular diseases in both male and female patients with androgenetic alopecia
People with androgenetic alopecia, both men and women, are more likely to develop heart diseases in the future.
research The Impact of Gender Affirming Hormone Therapy on Physical Performance
Gender-affirming hormone therapy improves physical performance in trans men to the level of cisgender men, while in trans women, it increases fat mass and decreases muscle mass, with no advantage in physical performance after 2 years.
research Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin
Special proteins are important for skin balance, healing, and aging, and affect skin stem cells.
research Book Reviews
Both books are useful for professionals, but "Exacting Beauty" is more comprehensive and practical.
research Controversies in plastic surgery: Suction-assisted lipectomy (SAL) and the hCG (human chorionic gonadotropin) protocol for obesity treatment
The document concludes that the hCG protocol may help in obesity treatment and could be scientifically justified, but more research is needed.