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GlossaryBrain-Derived Neurotrophic Factor

protein supporting neuron growth and survival in the brain

Brain-Derived Neurotrophic Factor (BDNF) is a protein that plays a crucial role in the growth, maintenance, and survival of neurons in the brain. It is essential for cognitive functions such as learning and memory, and it also supports the health of existing neurons while encouraging the growth of new ones.

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Control of Human Hair Growth by Neurotrophins: Brain-Derived Neurotrophic Factor Inhibits Hair Shaft Elongation, Induces Catagen, and Stimulates Follicular Transforming Growth Factor Beta 2 Expression

research Control of Human Hair Growth by Neurotrophins: Brain-Derived Neurotrophic Factor Inhibits Hair Shaft Elongation, Induces Catagen, and Stimulates Follicular Transforming Growth Factor β2 Expression

64 citations , March 2005 in “Journal of Investigative Dermatology”

Brain-Derived Neurotrophic Factor (BDNF) slows down hair growth and promotes hair follicle regression.

research Histone deacetylase inhibitors promote neurosteroid‐mediated cell differentiation and enhance serotonin‐stimulated brain‐derived neurotrophic factor gene expression in rat C6 glioma cells

35 citations , April 2009 in “Journal of Neuroscience Research”

HDAC inhibitors help brain cells grow and improve brain function.

research Reduced serum brain-derived neurotrophic factor in patients with first onset vitiligo

9 citations , December 2014 in “Neuropsychiatric Disease and Treatment”

People with first-time vitiligo have lower levels of a certain brain protein compared to healthy individuals.

research Serum brain‐derived neurotrophic factor and vitamin D: Two concordant players controlling depression among alopecia areata and vitiligo patients: A case–control study

6 citations , March 2023 in “Journal of Cosmetic Dermatology”

Low levels of BDNF and vitamin D are linked to higher depression in alopecia areata and vitiligo patients.

research Evaluation of serum brain-derived neurotrophic factor to assess the association between psoriasis and depression

2 citations , September 2015 in “Journal of the Egyptian Women's Dermatologic Society (Print)”

People with psoriasis and depression have lower BDNF levels, which could help measure depression in those with psoriasis.

research Correlation between serum brain-derived neurotrophic factor level and depression severity in alopecia areata patients

1 citations , June 2022 in “International Journal of Health Sciences”

Lower BDNF levels link to worse depression in alopecia areata patients.

research Female Pattern Hair Loss and Negative Psychological Impact: Possible Role of Brain-derived Neurotrophic Factor (BDNF)

July 2023 in “Dermatology practical & conceptual”

Women with Female Pattern Hair Loss may experience more stress, anxiety, and depression, and have lower levels of BDNF, which could predict the psychological impact.

research Brain-derived nerve factor and neurotrophins in androgenetic alopecia

10 citations , July 2011 in “British Journal of Dermatology”

Lower growth factors linked to balding in androgenetic alopecia.

research Association between Serum Brain-derived Neurotrophic Factor and 25-OH Vitamin D Levels with Vitamin D Receptors Gene Polymorphism (rs2228570) in Patients with Autoimmune Thyroiditis and Hypothyroidism

7 citations , August 2021 in “Open Access Macedonian Journal of Medical Sciences”

The VDR gene polymorphism does not affect BDNF levels in autoimmune thyroiditis and hypothyroidism patients.

Psychological Stress Impact on Neurotrophic Factor Levels in Patients With Androgenetic Alopecia and Correlation With Disease Progression

research Psychological stress impact neurotrophic factor levels in patients with androgenetic alopecia and correlated with disease progression

October 2024 in “World Journal of Psychiatry”

Stress worsens hair loss in androgenetic alopecia.

research Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR.

122 citations , June 1998 in “PubMed”

Neurotrophins regulate nerve growth by balancing promotion and suppression.

research Epithelial growth control by neurotrophins: leads and lessons from the hair follicle

99 citations , January 2004 in “Progress in brain research”

Neurotrophins are important for hair growth and could help treat hair loss.

research A role for p75 neurotrophin receptor in the control of apoptosis‐driven hair follicle regression

96 citations , October 2000 in “The FASEB Journal”

The p75 neurotrophin receptor is important for hair follicle regression by controlling cell death.

research Overexpression of neurotrophin 4 in skin enhances myelinated sensory endings but does not influence sensory neuron number

34 citations , July 2006 in “The Journal of Comparative Neurology”

Increasing neurotrophin 4 in skin boosts nerve endings but not sensory neuron count.

research Inhibitory Effects of Polyacetylene Compounds from Panax ginseng on Neurotrophin Receptor-Mediated Hair Growth

7 citations , January 2017 in “Biological & Pharmaceutical Bulletin”

Certain compounds from Panax ginseng can block proteins that affect hair growth, potentially helping treat hair loss.

research In vitro Differentiation of Adipose-Derived Stem Cells into Hair Cell-Like Cells in Guinea Pigs

3 citations , December 2007 in “Journal of Otology”

Guinea pig fat stem cells can become hair cell-like cells in a lab.

research The relationship between psychological distress and neurotrophins in patients with alopecia areata: A crosssectional study

January 2025 in “TURKDERM”

Alopecia areata patients experience more psychological distress, linked to certain neurotrophin levels.

research The study of the altering of cytokines and growth factors secreted by cultured balding dermal papilla cells

January 2012

Neurotrophins may contribute to genetic hair thinning by inhibiting hair growth.

research Stress-related skin disorders

67 citations , July 2016 in “Reviews in Endocrine and Metabolic Disorders”

Stress can worsen skin conditions by affecting hormone levels and immune response.

research Integrative analysis reveals ncRNA-mediated molecular regulatory network driving secondary hair follicle regression in cashmere goats

50 citations , March 2018 in “BMC Genomics”

Non-coding RNAs help control hair growth cycles in cashmere goats, suggesting ways to improve cashmere production.

research Investigating the synergic effects of valproic acid and crocin on BDNF and GDNF expression in epidermal neural crest stem cells

10 citations , January 2020 in “Acta Neurobiologiae Experimentalis”

Valproic acid and crocin together boost cell growth and may help treat nerve injuries.

research Multipotent Neural Crest Stem Cell-Like Cells from Rat Vibrissa Dermal Papilla Induce Neuronal Differentiation of PC12 Cells

10 citations , January 2014 in “BioMed research international”

Rat whisker cells can help turn other cells into nerve cells and might be used to treat brain injuries or diseases.

The Beneficial Effects of Chick Embryo Extract Preconditioning on Hair Follicle Stem Cells: A Promising Strategy to Generate Schwann Cells

research The beneficial effects of chick embryo extract preconditioning on hair follicle stem cells: A promising strategy to generate Schwann cells

5 citations , January 2023 in “Cell proliferation”

Chick embryo extract helps rat hair follicle stem cells potentially turn into Schwann cells, important for the nervous system.

research Progesterone Promotes Anti-Anxiety/Depressant-like Behavior and Trophic Actions of BDNF in the Hippocampus of Female Nuclear Progesterone Receptor, but Not 5α-Reductase, Knockout Mice

4 citations , January 2025 in “International Journal of Molecular Sciences”

Progesterone reduces anxiety and depression in female mice by increasing BDNF in the brain, needing 5α-reduction and estradiol.

research 690 Platelet activation during PRP preparation for therapeutic use

July 2024 in “Journal of Investigative Dermatology”

PRP preparation partially activates platelets, causing varied growth factor release.

research Gene polymorphisms and serum levels of BDNF and CRH in vitiligo patients

July 2022 in “PLOS ONE”

Certain gene variations and different levels of BDNF and CRH hormones are linked to vitiligo.

The Plastic and Functional Changes in Hippocampal Neurons During Pregnancy, Delivery, and Postpartum Are Reversed by Offspring Deprivation

research The Plastic and Functional Changes in Hippocampal Neurons During Pregnancy, Delivery and Postpartum are Reversed by Offspring Deprivation

August 2020 in “Current psychopharmacology”

Pregnancy and nursing increase certain brain activities in rats, but these changes disappear when the babies are taken away.

research Hair follicle stem cell-derived secretome protects astrocytes in an in vitro ischemia/reperfusion model

March 2025 in “Anatomy & Cell Biology”

Hair follicle stem cell secretions may help protect brain cells and improve stroke recovery.

research PEGylated Flavonoid Aspasomes as a Brain-Targeted Nano-Vesicular Platform for Enhanced Neuroprotection in Stress-Induced Cognitive Dysfunction

May 2026 in “AAPS PharmSciTech”

PEGylated flavonoid Aspasomes improve brain protection and memory in stress-related disorders.

Expression Patterns of Glial Cell Line-Derived Neurotrophic Factor, Neurturin, Their Cognate Receptors GFRα-1, GFRα-2, and Common Signal Transduction Element c-Ret in Human Skin Hair Follicles

research Expression patterns of the glial cell line–derived neurotrophic factor, neurturin, their cognate receptors GFRα-1, GFRα-2, and a common signal transduction element c-Ret in the human skin hair follicles

18 citations , January 2008 in “Journal of The American Academy of Dermatology”

Certain proteins and their receptors are more active during the growth phase of human hair and could be targeted to treat hair disorders.