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Mutations at Val-889 and Arg-752 disrupt key interactions in the androgen receptor, affecting its function.

The study created a model to help design new inhibitors for steroidal 5α-reductase enzymes.

Arabidopsis plants adjust gene expression to maintain balance when auxin pathways are disrupted.

A new genetic variant causes BRESHECK syndrome by disrupting cell growth and stress response.

MEK and BRAF inhibitors increase sebum production and accumulation, which could cause acne-like side effects.

Megestrol acetate helps fat-derived stem cells grow, move, and turn into fat cells through a specific receptor.

Certain ESR1 gene variations may affect hormone levels and fat distribution in women with high male hormone levels.

Scientists made two new chemicals that might help treat diseases caused by male hormones.

Beta-sitosterol and stigmasterol might help prevent hair loss by blocking a specific enzyme.

Abuse of anabolic steroids in Iraqi athletes leads to negative effects on hormones, liver and kidney function, blood sugar, and cholesterol levels.

Some bacteria use arsenic compounds as antibiotics, and others have evolved resistance; a particular arsenic-based compound shows potential as a new antimalarial treatment.

Understanding how androgens and their receptors work can lead to improved treatments for skin diseases.

Steroids, particularly estrogens and 5α-reductase inhibitors, affect blood vessel-related hair growth processes in hair follicle cells.

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

Androgen conjugates might be better indicators of skin sensitivity to hormones in women with excessive hair growth.

The research found that compound 6, a newly created steroid, is more effective at inhibiting 5α-reductase (an enzyme) than current treatments, suggesting it could be a better option for treating urinary tract symptoms in men.

The methods accurately measured brain androgens, showing most 5α-androstane-3α,17β-diol comes from outside the brain, while androsterone is both transported and made in the brain.

New compounds were made that effectively block a specific enzyme related to androgen conditions.

The conclusion is that tritium-labeled testosterone metabolites can be made and are better converted into dihydrotestosterone in skin cells than in prostate tissue.

Acne involves increased lipid production and inflammation, affecting skin cell behavior and treatment resistance.

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.

SSAT is a key enzyme affecting cell growth and metabolism, with potential but risky use in disease treatment.

Changing neuroactive steroids in baby male rats affects their memory and learning differently as they grow up.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

Finasteride doesn't affect antipyrine metabolism, so interactions with cytochrome P-450 enzyme drugs are unlikely.

Human bone cells mainly produce a type 1 enzyme that may help regulate bone health.

Estrogens can reduce DHT production in hair follicles, but are less effective than finasteride and progesterone.