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Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.

Using two drugs together, Flutamide and 4-MA, is more effective for blocking male hormones than using each one alone.

Finasteride affects frog testes by increasing testosterone, decreasing 5α-DHT, and impacting genes related to reproduction and other functions.

Gene mutations can cause problems in male genital development.

Spironolactone most effective for hirsutism, but has side effects.

Scientists made the first metal-based compounds from a nonsteroidal antiandrogen drug, which showed potential in fighting both hormone-dependent and independent prostate cancer cells.

Multimodal minoxidil microemulsion is more effective in treating hair loss than minoxidil alone.

The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.

α-spinasterol from Melandrium firmum can help reduce prostate enlargement.

Skin diseases linked to insulin resistance should be managed to prevent diabetes and reduce heart disease risk.

The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.

Women with PCOS who had antiandrogenic treatment before pregnancy had fewer complications than those without treatment.

Finasteride affects offspring's antioxidant enzymes in epididymis, possibly disrupting sperm maturation.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Women with PCOS have higher 5α-reductase activity, which may be linked to insulin resistance.

Finasteride can cause lasting sexual dysfunction, depression, and other side effects, needing more research for treatment.

De nouvelles thérapies promettent de mieux traiter la perte de cheveux due à l'alopécie androgénétique.

TRM21 helps control flavonoid production and root hair growth in Arabidopsis thaliana.

Blocking glucocorticoid receptors improves glucose metabolism in a PCOS mouse model.

The research improved understanding of twin births and fertility in Tibetan sheep, helping animal farming.

The guidelines ensure accurate genetic testing and reporting for 21-hydroxylase deficiency.

Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Patient had scalp allergy from minoxidil; test helped identify cause and suggest alternative treatments.

Finasteride doesn't affect hormone levels in normal men.

Finasteride doesn't affect bone density in male rats.

Finasteride reduces dihydrotestosterone, increases testosterone, and may treat hirsutism in women.

Finasteride caused enlarged breast tissue in a 62-year-old man.

The severity of symptoms in nonclassical congenital adrenal hyperplasia is not determined by CYP21A2 gene variations.