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GlossarycAMP response element-binding protein

regulates gene transcription in response to cellular signals

cAMP response element-binding protein (CREB) is a cellular protein that binds to specific DNA sequences called cAMP response elements, thereby regulating the transcription of certain genes. It plays a crucial role in various cellular processes, including the growth and survival of cells, by responding to hormonal signals and other external stimuli.

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The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function

research The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function

72 citations , January 2003 in “American Journal of Pathology”

A protein called CBP is found in prostate cancer and can increase the effectiveness of certain prostate cancer treatments.

research Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport

December 2023 in “Journal of ethnopharmacology”

Tribuloside can increase skin pigmentation by enhancing melanin production and distribution.

Chromatin Architectural Protein CTCF Controls Epidermal Barrier Formation, Hair Follicle Fate Maintenance, and Suppresses Inflammatory Responses in the Skin Epithelium

research 874 Chromatin architectural protein CTCF controls epidermal barrier formation, hair follicle fate maintenance and suppresses inflammatory responses in the skin epithelium

April 2017 in “Journal of Investigative Dermatology”

The protein CTCF is essential for skin development, maintaining hair follicles, and preventing inflammation.

research Proteome Analysis of Human Sebaceous Follicle Infundibula Extracted from Healthy and Acne-Affected Skin

62 citations , September 2014 in “PLoS ONE”

Acne-affected skin has more inflammation-related proteins and bacteria than healthy skin.

Deletion of DNA Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D

research Deletion of Deoxyribonucleic Acid Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D

277 citations , July 2002 in “Molecular Endocrinology”

Removing part of the vitamin D receptor stops vitamin D from working properly.

GLI2-Specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells

research GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells

39 citations , March 2008 in “Journal of biological chemistry/The Journal of biological chemistry”

GLI2 increases follistatin production in human skin cells.

research cis-Element- and Transcriptome-Based Screening of Root Hair-Specific Genes and Their Functional Characterization in Arabidopsis

188 citations , May 2009 in “Plant physiology”

Researchers found 19 genes important for root hair growth in a plant called Arabidopsis.

Zinc in the Soil and Its Importance for Plants and Human Health: An Integrated Review

research Zinc in the Soil and Its Importance for the Plants and Human Health. An integrated review

January 2021 in “Middle East journal of applied sciences”

Zinc is essential for plant growth and human health, but many soils lack enough zinc, affecting crops and potentially leading to health problems.

Stress-Induced c-Jun-Dependent Vitamin D Receptor Activation Dissects the Non-Classical VDR Pathway from the Classical VDR Activity

research Stress-induced c-Jun-dependent Vitamin D Receptor (VDR) Activation Dissects the Non-classical VDR Pathway from the Classical VDR Activity

31 citations , January 2007 in “Journal of biological chemistry/The Journal of biological chemistry”

Stress activates a special function of the Vitamin D receptor with the help of c-Jun, which can also prevent cell death.

research The Metabolism and Control Mechanism of Human Hair Follicles

22 citations , April 2015 in “Current problems in dermatology”

Human hair follicles have a unique metabolism that changes between growth stages and may contribute to baldness.

Bioinformatics Analysis of Genes Associated with Patchy-Type Alopecia Areata: CD2 May Be a New Therapeutic Target

research Bioinformatics analysis of genes associated with the patchy-type alopecia areata: CD2 may be a new therapeutic target

4 citations , September 2019 in “Biomedical Papers/Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc Czech Republic”

CD2 might be a new treatment target for patchy alopecia areata.

research Activation of cAMP Signaling in Response to α-Phellandrene Promotes Vascular Endothelial Growth Factor Levels and Proliferation in Human Dermal Papilla Cells

6 citations , August 2022 in “International journal of molecular sciences”

α-Phellandrene may help prevent hair loss by increasing growth factors and cell growth in hair cells through a specific signaling pathway.

research Photosensory Function, Reception and Response in Human Skin

January 2021 in “Journal of clinical and cosmetic dermatology”

Human skin responds to light with protective mechanisms, but more research is needed to understand these processes and their implications for health and therapy.

Bioinformatic Analysis of Gene Expression Data Reveals Src Family Protein Tyrosine Kinases as Key Players in Androgenetic Alopecia

research Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia

June 2023 in “Frontiers in Medicine”

Protein tyrosine kinases are key in male pattern baldness, affecting skin structure, hair growth, and immune responses.

research SPT6 maintains epidermal homeostasis by inhibiting an NF-κB-positive feedback loop to prevent excessive inflammation

April 2026 in “Cellular and Molecular Immunology”

SPT6 prevents excessive skin inflammation by blocking a feedback loop.

research Functional Analysis of VDR Gene Mutation R343H in A Child with Vitamin D-Resistant Rickets with Alopecia

6 citations , November 2017 in “Scientific reports”

The R343H mutation in the VDR gene causes vitamin D-resistant rickets with alopecia by impairing specific gene activity.

research Human Female Hair Follicles Are a Direct, Nonclassical Target for Thyroid-Stimulating Hormone

90 citations , December 2008 in “Journal of Investigative Dermatology”

Thyroid-stimulating hormone affects hair follicles but doesn't change hair growth or color.

research Corticotropin releasing hormone and the skin

137 citations , January 2006 in “Frontiers in bioscience”

CRH in the skin acts like the body's stress response system, affecting cell behavior and immune activity.

research Dissecting the Impact of α-MSH-MC1R-cAMP Signaling on UVA-Induced Stress in Fibroblasts - Implications for Regulation of Cutaneous Photoaging

January 2026 in “Aging and Disease”

The α-MSH-MC1R-cAMP pathway does not protect skin cells from UVA damage.

Androgen Receptor Activation Integrates Complex Transcriptional Effects in Osteoblasts, Involving the Growth Factors TGF-β and IGF-I, and Transcription Factor C/EBPδ

research Androgen receptor activation integrates complex transcriptional effects in osteoblasts, involving the growth factors TGF-β and IGF-I, and transcription factor C/EBPδ

11 citations , July 2015 in “Gene”

DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.

research The Hair Follicle as an Estrogen Target and Source

159 citations , July 2006 in “Endocrine Reviews”

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

research Eclipta alba, An Antioxidant-Rich Memory Enhancer: In-Silicoand In-Vivo Evidence with Specific Insight into Alzheimer’s Disease

1 citations , November 2023 in “Indian Journal of Science and Technology”

Eclipta alba may improve memory and help treat Alzheimer's disease.

Roles of Msx and Dlx Homeoproteins in Vertebrate Development

research Roles for Msx and Dlx homeoproteins in vertebrate development

234 citations , April 2000 in “Gene”

Msx and Dlx genes are crucial for development, controlling cell behaviors like growth and differentiation through their roles as gene regulators.

research Molecular mechanism for transcriptional regulation of the parathyroid hormone gene by Epiprofin

March 2025 in “FEBS Journal”

Epiprofin suppresses parathyroid hormone gene activity, helping regulate calcium levels and could be a treatment target for hyperparathyroidism.

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

66 citations , February 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Adenosine may promote hair growth by increasing FGF-7 levels in dermal papilla cells.

research Single-Cell Proteomics Uncovers Dual Traits of Dermal Sheath Cells in Wound Repair

1 citations , January 2025 in “Advances in Wound Care”

Dermal sheath cells help heal wounds by showing both skin and connective tissue traits.

research Follicular Fluid: A Powerful Tool for the Understanding and Diagnosis of Polycystic Ovary Syndrome

45 citations , May 2022 in “Biomedicines”

Analyzing follicular fluid can help predict and improve outcomes for women with PCOS undergoing fertility treatments.

A Novel Point Mutation in the Ligand-Binding Domain of the Human Glucocorticoid Receptor Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus in Conferring Transactivational Activity

research A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity

91 citations , May 2005 in “The Journal of Clinical Endocrinology & Metabolism”

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

research Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

March 2023

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

research Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

March 2023

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.