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Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

research Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

6 citations , September 2015 in “Journal of Medicinal Chemistry”

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

research Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin

201 citations , May 2001 in “Proceedings of the National Academy of Sciences”

Overexpression of COX-2 in mice skin causes abnormal skin and hair development.

research The mineralocorticoid receptor plays a transient role in mouse skin development

12 citations , August 2015 in “Experimental Dermatology”

The mineralocorticoid receptor temporarily affects mouse skin development, but the glucocorticoid receptor has a more lasting impact.

Influence of the Alkylsulfonylamino Substituent Located at the 6-Position of 2,2-Dimethylchromans Structurally Related to Cromakalim: From Potassium Channel Openers to Calcium Entry Blockers?

research Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: From potassium channel openers to calcium entry blockers?

6 citations , April 2014 in “European journal of medicinal chemistry”

New compounds similar to cromakalim were less effective at inhibiting insulin release but improved in solubility and one acted as a calcium entry blocker, not a potassium channel opener.

research Study on the regulatory effect of Ligusticum chuanxiong on inflammation of human dermal papilla cells in alopecia areata based on network pharmacology and in vitro experiment

July 2024 in “Research Square”

research Vitamin D Receptor, UVR, and Skin Cancer: A Potential Protective Mechanism

51 citations , September 2008 in “Journal of Investigative Dermatology”

Vitamin D receptor may help protect against UV-induced skin cancer.

Combined Oral Contraceptives Promote Androgen Receptor And Estrogen Receptor Alpha Upregulation In The Female Prostate (Skene’s Paraurethral Glands) Of Adult Gerbils (Meriones Unguiculatus)

research Combined oral contraceptives promote androgen receptor and oestrogen receptor alpha upregulation in the female prostate (Skene’s paraurethral glands) of adult gerbils (Meriones unguiculatus)

3 citations , January 2018 in “Reproduction, Fertility and Development”

Birth control pills increase certain receptor activities in female gerbil prostate glands and can lead to prostate changes.

research Promotion of Insulin-Like Growth Factor-I Production by Sensory Neuron Stimulation; Molecular Mechanism(s) and Therapeutic Implications

23 citations , December 2008 in “Current medicinal chemistry”

Stimulating sensory neurons can increase IGF-I production, which may help treat various diseases and improve tissue health.

research CD271 orchestrates skin structure, differentiation, and inflammation via PI3K/Akt and PKCα/ERK pathways

October 2025 in “Cell Death and Disease”

CD271 is crucial for maintaining healthy skin and preventing inflammation.

research S.04.04 Social isolation alters GABAA receptors plasticity and function: effect of ethanol

October 2007 in “European Neuropsychopharmacology”

research Ligand‐Independent Actions of the Vitamin D Receptor: More Questions Than Answers

11 citations , November 2021 in “JBMR plus”

The vitamin D receptor can act without its usual activating molecule, affecting hair growth and skin cancer, but its full range of actions is not well understood.

research Reduced levels of 5-α reductase 2 in adult prostate tissue and implications for BPH therapy

39 citations , February 2011 in “The Prostate/The prostate”

Some men's prostate tissues have low enzyme levels due to genetic changes, possibly affecting treatment for prostate enlargement.

research Chitosan Nanoparticulate System Loaded with Cannabidiol: A Topical Formulation for Potential Alopecia Management

February 2025 in “Processes”

A new CBD topical formulation may effectively and safely treat alopecia.

research The Tumor Suppressor Actions of the Vitamin D Receptor in Skin

August 2013

Vitamin D receptor helps prevent skin tumors.

research The RAIG Family Member, GPRC5D, Is Associated with Hard-Keratinized Structures

64 citations , March 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

GPRC5D is linked to the formation of hair, nails, and certain tongue areas.

research Detection of Functionally Active Melanocortin Receptors and Evidence for an Immunoregulatory Activity of α-Melanocyte-Stimulating Hormone in Human Dermal Papilla Cells

60 citations , August 2005 in “Endocrinology”

αMSH may help regulate immune responses in hair follicles and its disruption could lead to hair loss.

research Pharmacological activities of extracts from different parts of Cirsium japonicum var spinossimum

January 2024 in “Tropical journal of pharmaceutical research”

Cirsium japonicum var. spinossimum seeds may help reduce inflammation and fight cancer.

research CCDC22 and CCDC93, two potential retriever-interacting proteins, are required for root and root hair growth in Arabidopsis

December 2022 in “Frontiers in plant science”

CCDC22 and CCDC93 are essential for root and root hair growth in Arabidopsis.

research Neurosteroids Involved in Regulating Inhibition in the Inferior Colliculus

19 citations , September 2006 in “Journal of Neurophysiology”

Neurosteroids help balance brain signals when certain inhibitions are reduced.

research Pharmacogenetics of the Androgen Metabolic Pathway

January 2010

CARI ONE Induces Anagen Phase of Telogenic Hair Follicles Through Regulation of β-Catenin, Stimulation of Dermal Papilla Cell Proliferation, and Melanogenesis

research CARI ONE Induces Anagen Phase of Telogenic Hair Follicles Through Regulation of β-Catenin, Stimulation of Dermal Papilla Cell Proliferation, and Melanogenesis

3 citations , April 2014 in “Journal of Dietary Supplements”

CARI ONE helps start hair growth and makes hair follicles bigger and more numerous.

research Advances in understanding epigenetic regulation of plant trichome development: a comprehensive review

1 citations , July 2023 in “Horticulture research”

Tiny RNA molecules help control the growth of plant hairs.

research Chemogenetic inhibition of Grpr- and/or Npff- expressing spinal neurons in mice suppresses chloroquine-evoked itch, but not signs of mechanical allodynia in a neuropathic pain model

April 2026 in “ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)”

research Anti-androgenic curcumin analogues as steroid 5-alpha reductase inhibitors

12 citations , March 2017 in “Medicinal Chemistry Research”

Some curcumin-like compounds can effectively and safely block the enzyme linked to hair loss and other conditions related to male hormones.

research In situ detection of retinoid-X receptor expression in normal and psoriatic human skin

42 citations , August 1995 in “British journal of dermatology/British journal of dermatology, Supplement”

RXR-alpha is strongly expressed in both normal and psoriatic skin and may help in skin cell differentiation and hair growth.

Artepillin C and Other Herbal PAK1-Blockers: Effects on Hair Cell Proliferation and Related PAK1-Dependent Biological Function in Cell Culture

research Artepillin C and Other Herbal PAK1-blockers: Effects on Hair Cell Proliferation and Related PAK1-dependent Biological Function in Cell Culture

23 citations , November 2015 in “Phytotherapy Research”

Certain herbal compounds, especially from bitter melon, can inhibit cancer growth and promote hair growth by blocking PAK1.

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