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GlossaryCardiac Progenitor Cells

stem cells in the heart that can become various heart cells

Cardiac Progenitor Cells (CPCs) are a type of stem cell found in the heart that have the potential to differentiate into various types of heart cells, such as cardiomyocytes, endothelial cells, and smooth muscle cells. These cells play a crucial role in heart development and repair, making them a significant focus of research for regenerative therapies aimed at treating heart disease and damage.

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research Fibroblast Growth Factor-9 Activates c-Kit Progenitor Cells and Enhances Angiogenesis in the Infarcted Diabetic Heart

17 citations , November 2015 in “Oxidative Medicine and Cellular Longevity”

Fibroblast Growth Factor-9 helps repair heart damage after a heart attack by creating new blood vessels, especially in diabetics.

research Stem cell secretome as a new booster for regenerative medicine

54 citations , August 2019 in “Bioscience trends”

Stem cells help repair tissue mainly by releasing beneficial substances, not by replacing damaged cells.

research RNA signaling in cellular plasticity during homeostasis and regeneration

April 2026 in “Current Opinion in Genetics & Development”

RNA is crucial for controlling cell flexibility and regeneration.

research c-Kit - The Novel Receptor: Physiological Roles, Downstream Signaling and Implications in Cancer

4 citations , January 2021 in “Journal of Clinical Medical Research”

c-Kit is important for heart regeneration and cancer development.

research Exploring pericyte and cardiac stem cell secretome unveils new tactics for drug discovery

26 citations , December 2016 in “Pharmacology & Therapeutics”

New drugs for heart disease may be developed from molecules secreted by stem cells.

research Sonic hedgehog signaling promotes angiogenesis of endothelial progenitor cells to improve pressure ulcers healing by PI3K/AKT/eNOS signaling

5 citations , October 2023 in “Aging”

Sonic hedgehog signaling helps heal pressure ulcers by improving blood vessel growth.

Nestin as a Marker of Unipotent Epithelial Progenitor Cells Differentiating into Outer Root Sheath Keratinocytes in Embryonic and Adult Hair Follicles

research Nestin as a marker of unipotent epithelial progenitor cells differentiate into outer root sheath keratinocytes in embryonic and adult hair follicles

June 2022 in “Research Square (Research Square)”

Nestin-expressing cells turn into a specific type of skin cell in hair follicles during development and in adults.

Nestin as a Marker of Unipotent Epithelial Progenitor Cell Differentiation into Outer Root Sheath Keratinocytes in Embryonic and Adult Hair Follicles

research Nestin as a marker of unipotent epithelial progenitor cell differentiation into outer root sheath keratinocytes in embryonic and adult hair follicles

May 2022 in “Research Square (Research Square)”

Nestin marks cells that can become a specific type of skin cell in hair follicles of both developing and adult mice.

research Current Understanding of the Pathways Involved in Adult Stem and Progenitor Cell Migration for Tissue Homeostasis and Repair

24 citations , May 2016 in “Stem Cell Reviews and Reports”

The document concludes that understanding how adult stem and progenitor cells move is crucial for tissue repair and developing cell therapies.

research Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation

29 citations , December 2016 in “The EMBO Journal”

Gata6 is important for protecting hair growth cells from DNA damage and keeping normal hair growth.

research Role of stem/progenitor cells in reparative disorders

29 citations , December 2012 in “Fibrogenesis & Tissue Repair”

Adult stem cells are important for tissue repair and have therapeutic potential, but more research is needed to fully use them.

research Novel in vitro culture condition improves the stemness of human dermal stem/progenitor cells

18 citations , November 2013 in “Molecules and Cells”

New culture method keeps human skin stem cells more stem-like.

research Progenitor‐cell‐enriched micrografts as a novel option for the management of androgenetic alopecia

14 citations , October 2019 in “Journal of Cellular Physiology”

Micrografts promote hair growth in androgenetic alopecia treatment.

research Discovering New Progenitor Cell Populations through Lineage Tracing and In Vivo Imaging

13 citations , February 2020 in “Cold Spring Harbor Perspectives in Biology”

New methods have helped find cells that create other cells in the body.

research Comparative analysis of stemness between dermal papilla cells and human dermalstem/progenitor cells

April 2025 in “Cellular and Molecular Biology”

Human dermal stem/progenitor cells can divide and differentiate more than hair follicle dermal papilla cells.

research Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds

301 citations , February 2019 in “Nature Communications”

The research found that different types of fibroblasts are involved in wound healing and that some blood cells can turn into fat cells during this process.

Nestin as a Marker of Unipotent Embryonic and Adult Progenitors Differentiating into an Epithelial Cell Lineage of the Hair Follicles

research Nestin is a marker of unipotent embryonic and adult progenitors differentiating into an epithelial cell lineage of the hair follicles

1 citations , October 2022 in “Scientific reports”

Nestin identifies specific progenitor cells in hair follicles that can become outer root sheath cells.

Isoproterenol Directs Hair Follicle-Associated Pluripotent (HAP) Stem Cells to Differentiate In Vitro to Cardiac Muscle Cells Which Can Be Induced to Form Beating Heart-Muscle Tissue Sheets

research Isoproterenol directs hair follicle-associated pluripotent (HAP) stem cells to differentiate in vitro to cardiac muscle cells which can be induced to form beating heart-muscle tissue sheets

29 citations , March 2016 in “Cell cycle/Cell cycle (Georgetown, Tex. Online)”

Isoproterenol helps hair follicle stem cells turn into beating heart muscle cells.

research Lineage potential, plasticity and environmental reprogramming of epithelial stem/progenitor cells

4 citations , May 2014 in “Biochemical Society Transactions”

Environmental cues can change the fate and function of epithelial cells, with potential for cell therapy.

research Circadian clock-mediated control of stem cell division and differentiation: beyond night and day

91 citations , August 2014 in “Development”

The circadian clock is crucial for tissue renewal and regeneration, affecting stem cell functions and having implications for health and disease.

Body Composition Changes and Inhibition of Fat Development In Vivo Implicate Androgen in Regulation of Stem Cell Lineage Allocation

research Body composition changes and inhibition of fat development in vivo implicates androgen in regulation of stem cell lineage allocation

37 citations , June 2011 in “Journal of Cellular Biochemistry”

Androgen is important in controlling stem cell differentiation, reducing fat development, and increasing lean mass.

Single-Cell Sequencing Reveals the Intermediate Cell State and Function of Dermal Papilla Cells in the Hair Follicle Cycle of Cashmere Goats

research Single-cell sequencing reveals the intermediate cell state and function of dermal papilla cells in the hair follicle cycle of cashmere goats

May 2020 in “Research Square (Research Square)”

Researchers found four key stages of cell development that are important for hair growth and shedding in cashmere goats.

research Neural progenitor cell-derived nanovesicles promote hair follicle growth via miR-100

29 citations , January 2021 in “Journal of nanobiotechnology”

Tiny particles from brain cells help hair grow by targeting a specific hair growth pathway.

research Progenitor Cell Dysfunctions Underlie Some Diabetic Complications

46 citations , June 2015 in “American Journal Of Pathology”

Diabetes causes lasting cell dysfunctions, leading to serious complications even after blood sugar is controlled.

Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis

research Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis

53 citations , August 2019 in “American journal of human genetics”

FOXN1 gene variants cause low T cells and immune issues from birth.

research Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells

47 citations , March 2019 in “Journal of immunology research”

Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.

research Existence of Neural Crest–Derived Progenitor Cells in Normal and Fuchs Endothelial Dystrophy Corneal Endothelium

44 citations , September 2016 in “American Journal Of Pathology”

Neural crest-derived progenitor cells in the cornea could help treat corneal issues without transplants.

The Overexpression of R-Spondin 3 Affects Hair Morphogenesis and Development Along with the Formation and Maturation of Hair Follicle Stem Cells

research The overexpression of R-spondin 3 affects hair morphogenesis and hair development along with the formation and maturation of the hair follicle stem cells

6 citations , September 2024 in “Frontiers in Physiology”

Overexpression of R-spondin 3 leads to sparse hair and impaired hair regeneration.

research Biocomposite nanofiber matrices to support ECM remodeling by human dermal progenitors and enhanced wound closure

87 citations , August 2017 in “Scientific Reports”

The nanofiber scaffolds improved skin wound healing by supporting cell growth and tissue repair.

research Early-age-dependent selective decrease of differentiation potential of hair-follicle-associated pluripotent (HAP) stem cells to beating cardiac-muscle cells

6 citations , July 2016 in “Cell cycle/Cell cycle (Georgetown, Tex. Online)”

Younger mice's hair-follicle stem cells are better at turning into heart cells than older mice's.