60 citations
,
February 2010 in “Gynecological Endocrinology” Metformin combined with lifestyle changes improves insulin resistance and reduces testosterone levels in women with PCOS more than lifestyle changes alone.
4 citations
,
July 2022 in “The Journal of Clinical Endocrinology & Metabolism” A specific genetic mutation causes POMC deficiency, leading to symptoms like weight gain and red hair.
2 citations
,
September 2008 in “Fertility and Sterility” Women with PCOS and higher BMI, especially those with morbid obesity, are at greater risk for depression.
September 2023 in “Journal of International Medical Research” Metformin increases FSH levels in PCOS, and KISS1 gene variations may influence PCOS development.
175 citations
,
January 2020 in “European Journal of Endocrinology” Test thyroid function in all obese patients and prioritize weight loss for hormonal balance.
5 citations
,
March 2021 in “F1000Research” A specific gene variation increases the risk of high uric acid and cholesterol in young Mexican males.
11 citations
,
July 2012 in “Current Opinion in Pediatrics” Skin problems can be signs of hormone-related disorders and recognizing them early is important for treatment.
14 citations
,
January 2025 in “Reproductive Medicine and Biology” PCOS diagnosis and treatment should consider race and ethnicity for accuracy.
March 2025 in “JEADV Clinical Practice” People with primary scarring alopecia have higher risks of other health issues like vitamin D deficiency and thyroid disease.
October 2023 in “Perinatology and reproductology from research to practice” Combining medication for dyslipidemia and insulin resistance with basic therapy improves outcomes for alopecia areata with metabolic syndrome.
3 citations
,
October 2024 in “International Journal of Molecular Sciences” Certain genes in fat tissue affect weight loss in women with PCOS.
16 citations
,
January 2013 in “Internal Medicine” Early hair whitening may indicate a higher risk of heart disease in young and middle-aged men.
4 citations
,
September 2023 in “Nutrients” Managing diabetes can lead to eating disorders, and eating disorders can make diabetes harder to control.
1 citations
,
January 2017 in “Current Dermatology Reports” Early baldness in men may indicate risks for obesity, metabolic syndrome, insulin resistance, and heart disease, similar to women with PCOS. Alopecia areata is often linked with autoimmune diseases and mental health issues. Certain hair disorders are due to genetic issues, and chemotherapy can cause hair loss through specific biological pathways. Iron deficiency's link to hair loss is still disputed.
32 citations
,
October 2023 in “Biomedicines” PCOS causes inflammation regardless of body weight.
January 2025 in “Japanese Journal of Gastroenterology and Hepatology” NAFLD is common in women with PCOS and may signal metabolic syndrome.
29 citations
,
March 2010 in “Journal of Endocrinological Investigation” Lipocalin-2 levels are higher in women with PCOS and may indicate insulin resistance.
4 citations
,
December 2021 in “Clinical and Experimental Reproductive Medicine” Higher estrone-to-estradiol ratios are linked to worse glucose metabolism and insulin resistance in women with PCOS.
60 citations
,
September 2001 in “Journal of the American Academy of Dermatology” Insulin resistance contributes to hormone imbalances in many women with polycystic ovary syndrome.
46 citations
,
June 2015 in “American Journal Of Pathology” Diabetes causes lasting cell dysfunctions, leading to serious complications even after blood sugar is controlled.
17 citations
,
June 2012 in “The Anatolian journal of cardiology” Premature hair graying may be a sign of increased risk for heart disease, indicating biological age is more important than actual age.
13 citations
,
August 2016 in “Medical Hypotheses” Hair characteristics might be early signs of Type 2 Diabetes and could help with early prevention.
36 citations
,
June 2019 in “eLife” The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.
1 citations
,
January 2008 in “touchREVIEWS in Endocrinology” Generalized glucocorticoid resistance causes hormone imbalances and varied symptoms due to gene mutations.
June 2019 in “Medicine and science in sports and exercise” The runner's bone injuries were linked to untreated Celiac Disease and low energy availability affecting her bone density.
Not having the gene PLAAT3 leads to fat loss, high insulin resistance, and abnormal fat levels in the blood due to a disruption in fat cell development and function.
March 2024 in “LGU journal of life sciences” Poor diets worsen PCOS symptoms in young women.
January 2017 in “Journal of clinical & experimental dermatology research” The case shows skin changes can indicate deeper health issues like insulin resistance, which are challenging to manage.
59 citations
,
October 2020 in “Stem Cell Reviews and Reports” Men have higher COVID-19 mortality rates than women due to biological and lifestyle factors.
43 citations
,
August 2010 in “Expert Opinion on Investigational Drugs” Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.