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Synthesis and Biological Evaluation of Amino-Pyridines as Androgen Receptor Antagonists for Stimulating Hair Growth and Reducing Sebum Production

research Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production

17 citations , August 2007 in “Bioorganic & Medicinal Chemistry Letters”

A compound made by Pfizer can potentially stimulate hair growth and reduce oil production, making it a good candidate for topical use.

research 3a-Phenylhexahydropentalene-1,6-dione

March 2026 in “Molbank”

A rigid compound with a common structural motif was successfully synthesized.

research New Nonsteroidal Molecules as Blockers of the Steroidogenic Pathway

January 2022 in “Current Enzyme Inhibition”

New nonsteroidal molecules can potentially increase dihydrotestosterone in neurons by blocking certain enzymes, without affecting prostate and seminal vesicle weight.

research Designed, Synthesis, In Vitro and Computational Analyses of Anticancer Nicotinamide Derivatives

February 2024 in “Indian Journal of Chemistry”

Compound N4 effectively kills breast cancer cells and compounds N2 and N3 have strong antibacterial and antifungal properties.

research Metabolite screening of aromatic amine hair dyes usingin vitrohepatic models

16 citations , October 2009 in “Xenobiotica”

The tested hair dye ingredients do not form harmful oxidized metabolites in the liver.

research Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier

4 citations , December 2024 in “European Journal of Medicinal Chemistry”

New pyrazole-based inhibitors show promise for treating metabolic diseases and other conditions.

Niosomal Versus Cubosomal Gels of Cetirizine Hydrochloride: Cost-Effective Permeation Enhancement for Potential Transdermal Application

research Niosomal versus cubosomal gels of cetirizine hydrochloride: Cost-effective permeation enhancement for potential transdermal application

October 2025 in “Pharmaceutical Development and Technology”

Cubosomal gels enhance skin absorption of cetirizine better than niosomal gels.

research Synthesis of N-Substituted 3-Oxo-17b- carboxamide-4-aza-5a-androstanes and the Tautomerism of 3-Oxo-4-aza-5-androstenes

4 citations , January 1998 in “Heterocycles”

Researchers made two new compounds that could be used for medicine.

Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

research Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

6 citations , September 2015 in “Journal of Medicinal Chemistry”

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

research Circumventing Mukaiyama oxidation: selective S–O bond formation via sulfenamide–alcohol coupling

January 2026 in “Beilstein Journal of Organic Chemistry”

A new, efficient method creates sulfinimidate esters from sulfenamides and alcohols without metals.

research Antitumour and toxic effects on Wistar rats of two new platinum complexes

11 citations , February 2002 in “European Journal of Clinical Investigation”

The new platinum complexes effectively increased survival in rats with tumors, despite some reversible side effects.

research Development, Optimization, and In Vitro/In Vivo Evaluation of Azelaic Acid Transethosomal Gel for Antidermatophyte Activity

19 citations , April 2023 in “Antibiotics”

Azelaic acid in a special gel is more effective against skin fungi than regular azelaic acid.

NUDT15 Polymorphism Explains Serious Toxicity to Azathioprine in Indian Patients With Chronic Immune Thrombocytopenia and Autoimmune Hemolytic Anemia: A Case Series

research NUDT15 polymorphism explains serious toxicity to azathioprine in Indian patients with chronic immune thrombocytopenia and autoimmune hemolytic anemia: a case series

10 citations , August 2020 in “Drug metabolism and drug interactions”

The NUDT15 gene variant causes severe side effects from azathioprine in some Indian patients.

research Generation of comparative pharmacophoric model for steroidal 5α-reductase I and II inhibitors: A 3D-QSAR study on 6-azasteroids

13 citations , January 2015 in “Steroids”

The study created a model to help design new inhibitors for steroidal 5α-reductase enzymes.

research BindingDB Entry 50021519: Discovery of (2S)-N-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment.

January 2025

research peri ‐Xanthenoxanthene (PXX): a Versatile Organic Photocatalyst in Organic Synthesis

11 citations , April 2021 in “Advanced synthesis & catalysis”

PXX is an effective and affordable photocatalyst for creating new chemical bonds in organic synthesis.

research Prooxidant and antioxidant action of 4-(4-phenoxybenzoyl)benzoic acid derivatives

2 citations , February 2004 in “Biopolymers”

4-(4-Phenoxybenzoyl)benzoic acid derivatives can both increase and decrease certain types of reactive oxygen species, and may be relevant to hair loss.

research Nitroxide pharmaceutical development for age-related degeneration and disease

24 citations , November 2015 in “Frontiers in Genetics”

Nitroxide drugs can safely and effectively treat age-related diseases like macular degeneration and cardiovascular issues.

research PD05-05 SINGLE CENTRE EXPERIENCE OF CHELATING AGENTS IN CYSTINURIA

1 citations , April 2022 in “The Journal of Urology”

Both penicillamine and tiopronin have significant side effects, but trying the alternative drug can be beneficial if the first is not tolerated.

research 2-Substituted 4-(Thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase

111 citations , August 2002 in “Journal of Medicinal Chemistry”

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

research Sulfur Containing Tyrosine Analogs Can Cause Selective Melanocytotoxicity Involving Tyrosinase-Mediated Apoptosis

16 citations , September 1999 in “Journal of Investigative Dermatology Symposium Proceedings”

research Evaluation of Biological Activity Exerted by an Aza-bicyclocarboxylic acid Derivative using Anischemia-Reperfusion Injury Model

3 citations , December 2018 in “Biomedical and pharmacology journal/Biomedical & pharmacology journal”

Compound 3 protects the heart from damage by activating A1-adenosine receptors.

research 420 Severe thiopurine-induced myelotoxicity and hair loss in Japanese patients with NUDT15 gene variant: A retrospective case-control study

April 2018 in “Journal of Investigative Dermatology”

Screening for the NUDT15 gene variant can prevent severe side effects from thiopurine drugs in East-Asian people.

research Structural characterization and dissolution profile of mycophenolic acid cocrystals

20 citations , February 2017 in “European journal of pharmaceutical sciences”

The MPA-ISO cocrystal improved solubility and dissolution rate, while the others did not.

Synthesis of Novel Androstane-N-Cyclohexyl-17-Carboxamides and Their Effect on 5α-Reductase Isoform 2, Androgen Receptor, and Androgen-Dependent Glands

research Synthesis of novel andostane-N-cyclohexyl-17-carboxamides, and their effect on the 5α-reductase isoform 2, the androgen receptor, and androgen-dependent glands

November 2021 in “Pharmaceutical Sciences”

New compounds were made and tested, with compound 6 showing potential for treating prostate-related diseases.

Preparation of 4-Aryl-2-Trifluoromethylbenzonitrile Derivatives as Androgen Receptor Antagonists for Topical Suppression of Sebum Production

research Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production

11 citations , August 2007 in “Bioorganic & Medicinal Chemistry Letters”

Scientists made a chemical (compound 4e) that can be applied on skin to reduce oil production, which can help with acne, but it might cause skin sensitivity to light.

$Synthesis and Structural Characterization of a New Dinuclear Platinum(III) Complex, [Pt2Cl4(NH3)2{μ-HN=C(O)Bu^t}2]$

research Synthesis and structural characterization of a new dinuclear platinum(III) complex, [Pt₂Cl₄(NH₃)₂{μ-HN=C(O)Bu^t}₂]

2 citations , November 2022 in “Acta crystallographica. Section B, Structural science, crystal engineering and materials./Acta crystallographica. Section B, Structural science, crystal engineering and materials”

A new platinum complex was made and studied, which might help fight cancer better.

research Natural Product-InspiredBis(trifluoromethyl) PhenylHydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitorsof Human Steroid 5α-Reductase Type-1: Synthesis, InVitro, and In Silico Studies

August 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

Certain hydroxycinnamate derivatives may effectively inhibit enzymes linked to hair loss with low toxicity.

research 267 Single- and multiple-ascending dose studies of DS-2325a, a KLK5 inhibitor for the treatment of Netherton syndrome

July 2024 in “Journal of Investigative Dermatology”

DS-2325a is safe and well-tolerated, supporting further development for Netherton Syndrome treatment.

research Detection of NUDT15 R139C variants and azathioprine utilization in patients with dermatologic conditions

December 2023 in “International Journal of Dermatology”

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