Allopregnanolone may help reduce inflammation and symptoms related to post-finasteride syndrome.
November 2023 in “Frontiers in Neuroendocrinology” Some people experience lasting sexual, psychological, and sleep problems after using finasteride or SSRI antidepressants, possibly due to similar underlying causes.
33 citations
,
January 2009 in “Journal of Cutaneous and Aesthetic Surgery” Finasteride reduces prostate cancer risk but may affect ejaculatory volume and requires careful consideration for young men.
90 citations
,
December 2007 in “Current Oncology” Non-hormonal treatments should be used first for sexual dysfunction in postmenopausal breast cancer patients on aromatase inhibitors, with hormones as a second option.
51 citations
,
August 2012 in “Differentiation” Mouse genital development depends on male or female hormones for specific features.
14 citations
,
May 2016 in “Therapeutic advances in urology” Taking tadalafil and finasteride together is safe and effective for treating urinary symptoms and erectile dysfunction in men with enlarged prostates.
2 citations
,
November 2019 in “BMC urology” The junction of the inner and outer prepuce with good blood flow is ideal for surgical flaps.
111 citations
,
August 2015 in “Reviews in Endocrine and Metabolic Disorders” 5α-reductase inhibitors may cause persistent sexual dysfunction and depression, needing more research on long-term effects.
August 2025 in “The Journal of Sexual Medicine” Finasteride, dutasteride, and silodosin have the highest risk for causing sexual dysfunction.
January 2025 in “Applied Sciences” Sulforaphane from broccoli may help treat certain cancers, hormone issues, and hair loss.
March 2024 in “Journal of Endocrinological Investigation” Finasteride treatment in rats changed the expression of genes related to psychiatric and neurological functions, and these changes persisted after stopping the drug.
3 citations
,
September 2023 in “International journal of impotence research” Post-finasteride syndrome causes lasting sexual, mental, and physical issues, needing more research for solutions.
May 2024 in “The journal of sexual medicine” Finasteride treatment may cause erectile dysfunction, but stopping it reverses these effects.
12 citations
,
March 2023 in “The FASEB Journal” Platelet-rich plasma can improve erectile function in older individuals by reducing prostate enlargement.
2 citations
,
September 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Tissue stiffness is influenced by contractility, which suppresses collagen breakdown.
226 citations
,
May 2004 in “Journal of Biological Chemistry” Collagen XXII is a marker for tissue junctions, aiding in structural integrity and found in muscles, heart, skin, and arthritic joints.
15 citations
,
October 1999 in “British Journal of Dermatology” Collagen remodeling is more active during hair growth stages.
September 2024 in “MedComm” Extracellular matrix stiffness affects how aggressively cancer cells invade.
January 2016 in “DOAJ (DOAJ: Directory of Open Access Journals)” Collagen XVII is important for cell functions and its absence can worsen cancer outcomes.
January 1994 in “Nihon Chikusan Gakkaiho” Collagen fibrils in mink skin change structure during hair growth, becoming looser and thicker in the active phase.
4 citations
,
September 2012 in “Journal of dermatological science” The hair follicle's connective tissue is a key source of a certain collagen in human scalp skin.
July 1995 in “Journal of Dermatological Science” 28 citations
,
October 1984 in “Journal of Investigative Dermatology”
October 2024 in “Dermatologica Sinica” ECM changes may play a role in hair loss, with differences between males and females.
52 citations
,
March 2015 in “Tissue Engineering Part C Methods” 3D images of skin show collagen is evenly spread, but elastic fibers are fewer near hair follicles.
20 citations
,
July 1987 in “Development Genes and Evolution”
July 2023 in “British journal of dermatology/British journal of dermatology, Supplement” Skin tumors with CYLD cutaneous syndrome show more NF-κB activity and less organized collagen.
4 citations
,
March 2021 in “Journal of Histotechnology” Hidradenitis suppurativa lesions have less collagen and elastin but more new blood vessels.
Collagen gel contraction in hair follicle culture is mainly influenced by the amounts of collagen, dermal papilla cells, and epithelium cells.
September 2001 in “Connective tissue” Type XII and XIV collagens help maintain hair follicle structure in bovine skin.