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A molecule called α-ketobutyrate was found to extend lifespan and improve aging-related symptoms in worms and mice by activating certain cellular pathways and may help develop anti-aging treatments for humans.

Caloric restriction improves skin and fur structure but can cause muscle loss and movement issues.

Loss of keratin K2 causes skin problems and inflammation.

Mutations in the ABCB6 gene cause Dyschromatosis Universalis Hereditaria.

People with PCNT mutations often develop severe insulin resistance and early-onset diabetes during childhood or adolescence.

The frizzy mouse and hairless rat mutations are due to changes in the Prss8 gene.

Secreted inhibitors of Wnt and IGF signaling control hair and tooth development, creating species-specific patterns.

A PKP1 gene mutation causes skin fragility and hair loss in Chesapeake Bay retriever puppies.

Not having enough cystatin M/E protein causes less hair growth and dry skin.

Too much β-catenin activity can mess up the development of mammary glands and make them more like hair follicles.

CREB, a protein that can promote cancer traits, is controlled by β-catenin in skin cancer cells.

Igf1r helps regulate hair growth cycles.

Hairless protein helps control hair growth by regulating vitamin D receptor activity.

Malt1 protease is essential for regulatory T cell function and could be targeted to boost antitumor immunity.

Activating β-catenin can turn skin cells into hair follicles.

Akt2 protein is essential for normal cell division in early mouse embryos.

Gender-affirming hormone therapy affects metabolism differently based on treatment type.

Bcl-2 overexpression protects against UVB damage but worsens hair loss from chemotherapy.

Removing Lrig1-positive stem cells in mice causes temporary loss of sebaceous glands.

Circ 0020938 slows down hair growth in cashmere goats.

TAK-279 effectively reduces psoriasis symptoms and is safe.

CB-03-01 is a promising skin cream for treating hormone-related skin problems without causing harmful body-wide effects.

Pregnancy increases certain GABA_A receptors in rat brains, influenced by steroid levels.

Two mouse mutations cause similar hair loss despite different skin changes.

XMU-MP-1 stops cell growth in a human mini-organ and reduces the effectiveness of the chemotherapy drug paclitaxel.

Hedgehog signaling is crucial for hair development, cadherins affect cell adhesion, neutrophils play a role in skin lesions, and BP230 autoantibodies impact skin stability.

Blocking CRF1 receptors improved male hormone levels and reduced testicular tumor size in men with a specific adrenal condition.

Mice that can regenerate tissue have cells that pause in the cell cycle, which is important for healing, similar to axolotls.

A specific genetic mutation causes POMC deficiency, leading to symptoms like weight gain and red hair.

Claudin-1 is crucial for maintaining skin barrier and preventing inflammation.