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LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

Early sunburn treatment with certain inhibitors may reduce skin cancer risk.

Neurosteroids and benzodiazepines reduce neuron excitability, with lasting effects on inhibitory neurons.

Two new compounds were found to build bone and muscle without affecting reproductive organs and skin oil glands.

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

TRPV1 affects sebaceous gland function and could help treat acne.

Brassinosteroids may be useful in treating cancer, infections, and other diseases.

Carvacrol activates the TRPV3 channel, which may help design new skin treatments.

Certain hydroxycinnamate derivatives may effectively inhibit enzymes linked to hair loss with low toxicity.

A brominated phenoxy compound effectively inhibits a human enzyme and shows potential for clinical use.

Mutations in certain receptors can cause diseases and offer new treatment options.

The fragrance cyclohexyl salicylate helps promote hair growth and increase hair stem cell numbers.

Non-coding RNA boosts retinoic acid production and signaling, aiding regeneration.

Chemicals called 4-(alkylthio)- and 4-(arylthio)-benzonitrile derivatives can potentially reduce oil production on skin, which could help treat conditions like acne and hair loss.

Kojyl cinnamate ester derivatives can promote hair growth by increasing adiponectin production in fat tissues.

Topical patidegib gel effectively treats basal cell carcinoma in Gorlin syndrome patients without causing the side effects seen with oral treatments.

Overexpressing COX-2 in mice skin reduces skin tumor development.

Coinheritance of BRCA2 and CYLD genes may lead to new treatment options for certain cancers.

Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.

Targeting the endocannabinoid system might help reduce hair pulling in trichotillomania.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

New steroids were effective in blocking male hormone receptors in hamster prostates.

Blocking Hedgehog signaling offers new treatment options for advanced basal cell carcinoma.

Cepharanthine may help treat COVID-19 by targeting similar pathways as other inflammatory diseases.

Targeting vitamin D and androgen receptors may effectively treat triple-negative breast cancer, especially with chemotherapy.

Delta-opioid receptors affect skin cell circadian rhythms, possibly impacting wound healing and cancer.

RXR agonists may promote hair growth in humans.

LDE225 is a promising skin-applied treatment for basal cell carcinoma with good skin penetration and effectiveness.

Hedgehog pathway inhibitors for advanced basal cell carcinoma can cause side effects, but managing them helps maintain treatment.