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research The changes in the expression levels of follicular markers in keratoacanthoma depend on the stage: keratoacanthoma is a follicular neoplasm exhibiting infundibular/isthmic differentiation without expression of CK15

28 citations , February 2014 in “Journal of Cutaneous Pathology”

Keratoacanthoma changes as it grows, showing different hair follicle characteristics at each stage.

research Abstract 2559: Targeting mTORC1 may provide selectivity for inhibiting proliferation of hair follicle stem/progenitor cells during tumor promotion

April 2012 in “Cancer research”

Blocking mTORC1 may help prevent skin cancer by stopping the growth of certain skin stem cells.

research The Tissue-dependent Keratin 19 Gene Transcription Is Regulated by GKLF/KLF4 and Sp1

119 citations , September 2000 in “Journal of Biological Chemistry”

GKLF/KLF4 and Sp1 control Keratin 19 gene activity, influencing cancer-related changes.

research Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle

53 citations , August 2005 in “The Journal of Cell Biology”

Sgk3 is essential for normal hair follicle growth and maintenance.

research PIK3CA gain-of-function mutation in Schwann cells leads to severe neuropathy and aerobic glycolysis through a non-cell autonomous effect

June 2025 in “Proceedings of the National Academy of Sciences”

A PIK3CA mutation in Schwann cells causes severe nerve damage and increased glycolysis, but early treatment can help.

research Removing all obstacles: A critical role for p53 in promoting tissue renewal

30 citations , April 2010 in “Cell Cycle”

The gene p53 is crucial for removing damaged cells to allow for healthy tissue renewal.

research Continuous MEK inhibition by AZD6244 (ARRY-142886) results in exhaustion of the cutaneous keratinocytic stem cell pool and resembles senescence driven skin aging

2 citations , May 2008 in “Journal of Clinical Oncology”

AZD6244 treatment causes skin aging effects by depleting skin stem cells.

research Logic-Based Modeling and Drug Repurposing for the Prediction of Novel Therapeutic Targets and Combination Regimens against E2F1-Driven Melanoma Progression

June 2023

Cialis and Finasteride could be repurposed to treat aggressive melanoma.

research 549 Temporary cell cycle arrest in human scalp hair follicles and their epithelial stem cells by ALRN-6924: A novel strategy to selectively protect p53-wildtype cells against paclitaxel-induced alopecia

1 citations , November 2022 in “Journal of Investigative Dermatology”

ALRN-6924 may prevent hair loss caused by chemotherapy.

research 200 The relationship between the expression of cytokeratin 5/6 and clinicopathologic factors in invasive breast carcinoma

March 2010 in “Ejc Supplements”

CK 5/6 expression in breast cancer is linked to negative hormone receptor status and higher tumor grade.

research Single‐center study to determine the safety and efficacy of CT‐707 in Chinese patients with advanced anaplastic lymphoma kinase‐rearranged non‐small‐cell lung cancer

5 citations , March 2020 in “Thoracic Cancer”

CT-707 is effective and safe for treating certain Chinese lung cancer patients.

research Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

136 citations , March 1998 in “Oncogene”

Overexpression of E2F1 can lead to skin tumors and disrupt hair growth.

research Cell cycle controls long-range calcium signaling in the regenerating epidermis

22 citations , April 2023 in “The Journal of Cell Biology”

Calcium signaling in skin cells is crucial for communication and regeneration.

research Editor's evaluation: Crosstalk with keratinocytes causes GNAQ oncogene specificity in melanoma

August 2021

Keratinocytes can reduce the survival of certain melanoma cells, suggesting new therapy paths.

A Mouse Model for Conditional Expression of Activated Beta-Catenin in Epidermal Keratinocytes

research A Mouse Model for Conditional Expression of Activated β-Catenin in Epidermal Keratinocytes

1 citations , August 2024 in “Transgenic Research”

Activated β-catenin affects hair growth and skin thickness, and changes are reversible.

research Re-Assessing K15 as an Epidermal Stem Cell Marker

36 citations , March 2011 in “Stem Cell Reviews and Reports”

research Dickkopf-related Protein 2 Promotes Hair Growth by Upregulating the Wnt/β-catenin Signaling Pathway in Human Dermal Papilla Cells

6 citations , January 2024 in “Annals of Dermatology”

Dickkopf-related Protein 2 can help hair grow by activating a specific cell pathway.

research A novel derivative of doxorubicin, AD198, inhibits canine transitional cell carcinoma and osteosarcoma cells in vitro

12 citations , September 2015 in “Drug Design Development and Therapy”

AD198 is more effective than doxorubicin in stopping certain dog cancer cells.

research Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation

19 citations , April 2024 in “Nature Cell Biology”

Type I Keratin 17 Protein Is Phosphorylated on Serine 44 by p90 Ribosomal Protein S6 Kinase 1 in a Growth- and Stress-Dependent Fashion

research Type I Keratin 17 Protein Is Phosphorylated on Serine 44 by p90 Ribosomal Protein S6 Kinase 1 (RSK1) in a Growth- and Stress-dependent Fashion

30 citations , December 2011 in “Journal of biological chemistry/The Journal of biological chemistry”

Keratin 17 is modified by RSK1 in response to growth and stress, affecting skin growth and stress response.

research OCT4 maintains self-renewal and reverses senescence in human hair follicle mesenchymal stem cells through the downregulation of p21 by DNA methyltransferases

57 citations , January 2019 in “Stem Cell Research & Therapy”

OCT4 helps hair stem cells renew and fight aging, potentially aiding hair regrowth.

research Effect of beta--catenin on regulating hair follicle cells' proliferation

January 2006 in “Chieh P'ou Hsueh Pao”

Beta-catenin boosts hair follicle cell growth by increasing c-myc expression.

research A novel nonsense CDH3 mutation in hypotrichosis with juvenile macular dystrophy

13 citations , February 2012 in “International Journal of Dermatology”

A new genetic mutation in the CDH3 gene causes hair loss and eye problems in young people.

research Ornithine decarboxylase expression in cutaneous papillomas in SENCAR mice is associated with altered expression of keratins 1 and 10.

33 citations , March 1994 in “PubMed”

High ODC and low K1 and K10 may indicate early skin tumors in mice.

research 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Affects Keratin 1 and Keratin 17 Gene Expression and Differentially Induces Keratinization in Hairless Mouse Skin

45 citations , March 1997 in “Journal of Investigative Dermatology”

research First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors

505 citations , October 2011 in “Journal of clinical oncology”

MK-2206 was safe and effectively blocked AKT signaling in cancer patients, warranting more trials.

research Genomic Organization and Amplification of the Human Keratin 15 and Keratin 19 Genes

12 citations , January 2000 in “Biochemical and Biophysical Research Communications”

The study mapped keratin 15 and 19 genes, aiding future genetic disorder research.

research Concerted gene duplications in the two keratin gene families

53 citations , May 1988 in “Journal of Molecular Evolution”

research Cyclic ADP-Ribose Modulates Intracellular Calcium Homeostasis and Anagen-Associated Signaling Pathways in Human Hair Follicle Dermal Papilla Cells

January 2026 in “Applied Sciences”

Cyclic ADP-ribose helps regulate calcium and signals that promote hair growth in hair follicle cells.

research Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch

8 citations , August 2014 in “Biochemical and Biophysical Research Communications”

ODC overexpression in hair cells increases tumor growth by reducing Notch signaling.

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