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research Dauricine attenuates Oct4/sonic hedgehog co‐activated stemness and induces reactive oxygen species‐mediated mitochondrial apoptosis via AKT/β‐catenin signaling in human neuroblastoma and glioblastoma stem‐like cells

5 citations , October 2023 in “Phytotherapy Research”

Dauricine may help treat certain brain cancers by reducing cancer cell growth and promoting cell death.

research Targeting noncanonical nuclear factor kappa B signalling in CYLD cutaneous syndrome by selective inhibition of IκB kinase alpha

June 2026 in “Strathprints: The University of Strathclyde institutional repository (University of Strathclyde)”

Topical IKKα inhibitors may help prevent CCS tumours.

research PAK4 signaling in health and disease: defining the PAK4–CREB axis

81 citations , February 2019 in “Experimental & Molecular Medicine”

PAK4 is crucial in cancer progression, brain development, and could be a therapeutic target, especially through the PAK4-CREB axis.

research Integrin-linked kinase inhibition via QLT0267 stops the epithelial outgrowth.

December 2015 in “OPAL (Open@LaTrobe) (La Trobe University)”

QLT0267 stops hair follicle cell growth and movement.

research Dermatologic adverse events associated with chemotherapy and targeted anticancer therapy

4 citations , January 2016 in “Dermatology Review”

Cancer treatments often cause skin, nail, and hair problems.

Multicentric Parallel Phase II Trial of the Polo-Like Kinase 1 Inhibitor BI 2536 in Patients With Advanced Head and Neck Cancer, Breast Cancer, Ovarian Cancer, Soft Tissue Sarcoma, and Melanoma. The First Protocol of the European Organization for Research and Treatment of Cancer Network of Core Institutes

research Multicentric parallel phase II trial of the polo-like kinase 1 inhibitor BI 2536 in patients with advanced head and neck cancer, breast cancer, ovarian cancer, soft tissue sarcoma and melanoma. The first protocol of the European Organization for Research and Treatment of Cancer (EORTC) Network Of Core Institutes (NOCI)

93 citations , May 2010 in “European Journal of Cancer”

BI 2536 had limited effectiveness against several advanced cancers and caused significant side effects.

research The remarkable legacy of the K6/ODC mouse: mechanisms of polyamine-promoted tumorigenesis revealed

April 2026 in “Amino Acids”

Polyamines are crucial for skin tumor development, and inhibiting them can prevent tumors.

research Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.

26 citations , June 2003 in “PubMed”

Alpha-difluoromethylornithine prevents cancer in mice but causes hair loss.

research Phase I safety and pharmacokinetic study of SU-014813 in combination with docetaxel in patients with advanced solid tumours

22 citations , May 2011 in “European Journal of Cancer”

The drug combination was safe and showed promise in treating advanced tumors.

research Axitinib-induced repigmentation of grey hair in a patient with metastatic renal cell carcinoma

June 2025 in “BMJ Case Reports”

Axitinib treatment turned a man's grey hair back to black.

research Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis

37 citations , January 2006 in “Carcinogenesis”

Antizyme slows skin tumor growth by reducing cell growth in mice.

research Caffeic acid N-[3,5-bis(trifluoromethyl)phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics

December 2022 in “Scientific Reports”

Compound 4 is a promising treatment for hair loss with low toxicity.

research Expression patterns of programmed cell death 4 protein in normal human skin and some representative skin lesions

37 citations , February 2007 in “Experimental Dermatology”

Increasing PDCD4 protein may help prevent or treat some skin cancers.

research Abstract 5357: Targeting mTORC1 suppresses proliferation of keratinocyte stem cells and inhibits skin tumor promotion in mice

October 2014 in “Cancer research”

Blocking mTORC1 reduces skin tumor growth in mice.

research Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors

136 citations , April 2013 in “Clinical Cancer Research”

The drug IPI-926 is safe at 160 mg daily and may help treat certain tumors, especially basal cell carcinoma.

research Protein Kinase C as a Therapeutic Target

87 citations , September 2006 in “Clinical Cancer Research”

Protein Kinase C shows promise for cancer treatment, but more research is needed to develop effective inhibitors.

research Abstract 1677: Epithelial hyperplasia induced by a selective B-Raf inhibitor, WYE-130600

1 citations , April 2010 in “Cancer Research”

WYE-130600 may cause skin thickening and irritation.

research O04 HPV8 E6 leads to Lrig1+ keratinocyte stem cell expansion

July 2023 in “British journal of dermatology/British journal of dermatology, Supplement”

HPV8 E6 gene causes growth of certain skin stem cells.

research 63418 JAK3/TEC kinase pathways are active in alopecia areata lesions, and their inhibition with Ritlecitinib prevents αCD3/αCD28+IL-2 induced immune privilege collapse in healthy hair follicles ex vivo

September 2025 in “Journal of the American Academy of Dermatology”

Ritlecitinib may help treat alopecia areata by protecting hair follicles.

research 1332 Janus kinase inhibitor increases hair growth by increasing beta-catenin activity in outer root sheath cells

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

JAK inhibitors help hair growth by boosting beta-catenin activity in hair root cells.

research Cell Density-Dependent Upregulation of PDCD4 in Keratinocytes and Its Implications for Epidermal Homeostasis and Repair

10 citations , December 2015 in “International Journal of Molecular Sciences”

PDCD4 is important for controlling skin cell growth and healing.

Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway

research 446 Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway

June 2018 in “The Journal of Sexual Medicine”

Finasteride helps female-pattern hair loss.

research 1392 Dkk4 regulates Wnt-dependent hair formation and pattern

April 2023 in “Journal of Investigative Dermatology”

Dkk4 protein helps control how hair grows and its arrangement.

research 085 Coordinate expressions of cyclin-dependent kinase inhibitors and high sulfur protein in human hair follicles

June 1996 in “Journal of Dermatological Science”

research 0928 Dkk4 fine-tunes Wnt activity for hair follicle patterning and initiation

July 2026 in “Journal of Investigative Dermatology”

research Comprehensive Safety Exposure‐Response Analysis to Support Ritlecitinib Dose Selection

May 2025 in “CPT Pharmacometrics & Systems Pharmacology”

A 50 mg non-loading dose of ritlecitinib is safe for adults and adolescents.

research Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild‐type and BK5.Akt^WT mice

8 citations , September 2013 in “Molecular carcinogenesis”

Rapamycin reduces skin cell growth and tumor development by affecting cell signaling in mice.

research 547 CDK9 Kinase Activation in Association with AFF1-SEC Initiate Epidermal Progenitor differentiation

November 2022 in “Journal of Investigative Dermatology”

NCSTN gene mutation causes abnormal skin cell differentiation and more inflammation, contributing to Hidradenitis Suppurativa.

research Synthesis, Anticancer and Molecular Docking Studies of 2-(4-chlorophenyl)-5-aryl-1,3,4-Oxadiazole Analogues

8 citations , January 2013 in “Medicinal chemistry”

The compound 4c showed strong potential as an anticancer agent.

research Analysis of Sequences Controlling Tissue-Specific and Hyperproliferation-Related Keratin 6 Gene Expression in Transgenic Mice

26 citations , February 1998 in “DNA and Cell Biology”

K6 gene expression can be controlled and manipulated in mice for studying skin disorders.

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