August 2007 in “Microscopy and Microanalysis” Hair fibers break by cuticle cell slipping, shape changing, cuticle fraying, and surface cracking when stretched under specific conditions.
133 citations
,
September 2013 in “Nature Reviews Molecular Cell Biology” Different types of stem cells and their environments are key to skin repair and maintenance.
6 citations
,
July 2025 in “Advanced Materials” Biomimetic cell membrane-coated scaffolds significantly enhance tissue regeneration by mimicking natural cellular environments.
January 2026 in “Immune Network” Regulatory T cells adapt to different environments to control inflammation and support tissue repair.
September 2025 in “Digital Commons - RU (Rockefeller University)” FOXC1 is essential for keeping hair follicle stem cells inactive and maintaining their environment for healthy hair growth.
66 citations
,
July 2015 in “Journal of Molecular Biology” The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.
2 citations
,
August 2012 in “Cell Stem Cell” The study showed that some hair follicle stem cells wake up to grow hair while others stay asleep, and that the environment around them is important for hair growth.
129 citations
,
May 2015 in “Cell Stem Cell” Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.
6 citations
,
August 2024 in “Biomacromolecules” The model helps test drugs for clubfoot fibrosis by mimicking cell environments and shows minoxidil reduces harmful collagen links.
3 citations
,
April 2019 in “Stem cells international” Markers CRABP1, Nestin, and Ephrin B2 are present in skin cancer environments and may influence their development.
14 citations
,
March 2020 in “Cold Spring Harbor Perspectives in Biology” Mouse spermatogenesis shows that stem cells can behave flexibly and move widely in open environments.
69 citations
,
January 1995 in “PubMed” Mouse melanocyte structure and function are influenced by genetics, hormones, and environmental factors.
57 citations
,
February 2013 in “Journal of Dermatological Science” Improving the environment and cell interactions is key for creating human hair in the lab.
35 citations
,
January 2014 in “Journal of Tissue Engineering” Cell-based therapies using dermal papilla cells and adipocyte lineage cells show potential for hair regeneration.
21 citations
,
March 2025 in “Journal of Extracellular Vesicles” Hydrogels can enhance stem cell activity, but more research is needed to optimize their use.
2 citations
,
August 2023 in “Ecotoxicology and environmental safety” Vitamin A helps rabbit skin cells grow and survive heat stress.
September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” Changing the structure of the hair follicle's environment can affect hair quality but doesn't stop hair growth.
113 citations
,
June 2019 in “F1000Research” Scarless healing is complex and influenced by genetics and environment, while better understanding could improve scar treatment.
21 citations
,
December 2023 in “Journal of Investigative Dermatology” Hair graying is caused by damage and cell depletion but might be temporarily reversible with drugs and hormones.
20 citations
,
October 2021 in “PLoS ONE” Newborn skin is uniquely prepared to adapt to new environments compared to adult skin.
August 2023 in “Cell Proliferation” Human cells in plasma-derived gels can potentially mimic hair follicle environments, improving hair regeneration therapies.
January 2026 in “Immunity & Inflammation” Autoimmune skin diseases result from genetic and environmental factors disrupting immune checkpoints.
34 citations
,
October 2011 in “Pathology Research International” Behçet's Disease may be caused by genetic and environmental factors leading to abnormal immune responses, and stress management and new treatments could improve patient outcomes.
4 citations
,
July 2022 in “Frontiers in Cell and Developmental Biology” The document concludes that understanding adult stem cells and their environments can help improve skin regeneration in the future.
1 citations
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January 2013 in “Journal of Investigative Dermatology” The document concludes that stem cells and their environments are crucial for skin and hair health and have potential for medical treatments.
March 2024 in “International Journal of Cosmetic Science” Dandruff is linked to increased T cells and weakened immune protection in hair follicles.
Current hair regeneration methods show promise but face challenges in maintaining cell effectiveness and creating the right environment for hair growth.
23 citations
,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Alopecia Areata is an autoimmune disease affecting hair follicles, influenced by genetic and environmental factors, with rodent models being essential for research.
September 2019 in “Journal of Investigative Dermatology” Mouse skin fibroblasts vary in function and adaptability based on their environment.
82 citations
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March 2016 in “Cell” The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.