June 2004 in “Journal of Investigative Dermatology” Apoptosis may play a role in feather and hair development, SF-36 is better for mental health in skin patients, a psoriasis gene is found in Caucasians, eosinophils might not be crucial for some skin allergies, and changes in atopic dermatitis could increase skin sensitivity.
49 citations
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April 2010 in “International Journal of Cosmetic Science” Hair ages as the cuticle wears down, especially beyond 1 meter from the root, affecting its strength and shine.
36 citations
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January 2004 in “European journal of cell biology” Without keratin 10, there's more growth and development of oil-producing skin cells.
25 citations
,
November 2012 in “Thermochimica Acta” Internal lipids in keratin fibers, like wool and hair, reduce water absorption and release.
24 citations
,
April 2016 in “Experimental Dermatology” Chemical treatments like dyeing, perming, and bleaching damage hair by altering amino acids and lipids.
8 citations
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March 2007 in “International Journal of Cosmetic Science” 6-O glucose linoleate helps human hair grow and produce lipids.
7 citations
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March 2005 in “International Journal of Cosmetic Science” Menopause reduces hair quality, but hormone therapy can help improve it.
46 citations
,
December 2018 in “Biomedical Optics Express” Raman spectroscopy could effectively guide skin cancer surgery by identifying tumor margins.
15 citations
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June 2016 in “Computers in Biology and Medicine” Ascorbyl Tetraisopalmitate penetrates skin better in the stratum corneum than in the infundibulum.
November 2023 in “Journal of Investigative Dermatology” The study explores the potential of adipose stem cell exosomes (ASCE) as regenerative therapeutics for atopic dermatitis. ASCEs, derived from human adipose mesenchymal stem cells, were tested on in vitro cell models, in vivo animal models, and one patient with atopic dermatitis. Results showed that ASCEs significantly reduced skin inflammation and improved the atopic dermatitis score by up to 30% in a dose-dependent manner. They also down-regulated major proinflammatory cytokines by 30-50% and promoted the synthesis of ceramides and dihydroceramides by 40-70%, enhancing skin barrier function. The findings suggest that ASCEs have strong regenerative and anti-inflammatory properties, making them promising candidates for treating inflammatory skin diseases like atopic dermatitis.
40 citations
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July 2019 in “Journal of Investigative Dermatology” Lack of a key enzyme causes severe skin issues and death in mice.
258 citations
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July 2005 in “Journal of lipid research” DGAT1 enzyme helps make diacylglycerols, waxes, and retinyl esters.
June 2023 in “Journal of biological chemistry/The Journal of biological chemistry” Sdr16c5 and Sdr16c6 genes regulate a key point in lipid production that affects eye and skin gland function.
April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” 848 genes related to fat and metabolism are less active in people with Central Centrifugal Cicatricial Alopecia.
December 2016 in “University of Birmingham Institutional Research Archive (University of Birmingham)” Glucocorticoids reduce fat production in liver cells, while androgens increase it in females; manipulating certain enzymes can influence these effects.
September 2023 in “International journal of molecular sciences” Targeting lipid metabolism can help treat advanced, resistant cancers.
59 citations
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May 2017 in “Scientific reports” ZDHHC13 is important for normal liver function and metabolism, affecting mitochondrial activity.
July 2025 in “Journal of Investigative Dermatology” Acne involves increased lipid production and inflammation, affecting skin cell behavior and treatment resistance.
81 citations
,
July 2008 in “The Journal of Clinical Endocrinology and Metabolism” Certain mutations in the H6PD gene cause Cortisone Reductase Deficiency by affecting hormone production.
1 citations
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January 2013 Glucosylceramides are essential for healthy skin and proper wound healing.
4 citations
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December 2022 in “Advanced science” SCD1 is important for hair growth by keeping the connection in skin cells where hair stem cells live stable.
24 citations
,
November 2015 in “Experimental Cell Research” Sebum from sebocytes is important for skin health and linked to conditions like acne and hair loss.
5 citations
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April 2014 in “Journal of Lipid Research” SCD1 inhibitors can cause skin issues in rodents.
26 citations
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March 2006 in “Endocrine, metabolic & immune disorders. Drug targets” This enzyme helps metabolize fatty acids and isoleucine, and could be key in treating neurological diseases and certain cancers.
22 citations
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October 2012 in “Journal of Investigative Dermatology” Altered retinoid metabolism in cicatricial alopecia suggests a balanced vitamin A diet may prevent the condition.
20 citations
,
June 2024 in “Journal of Autoimmunity” Inflammation in rheumatoid arthritis increases steroid activation in cells, reducing inflammation.
54 citations
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May 2015 in “Endocrinology” Manipulating 5α-reductase type 2 can affect liver fat production and glucocorticoid effects.
33 citations
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March 2018 in “Trends in cell biology” Metabolism plays a key role in determining stem cell fate.
August 2016 in “Journal of Investigative Dermatology” The endocannabinoid system affects oil production and inflammation in skin cells.
2 citations
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May 2021 in “Neuropathology & applied neurobiology/Neuropathology and applied neurobiology” Correct diagnosis and treatment are crucial for effective management of lipid storage myopathies.