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The research gives new understanding on how human steroid 5α-reductases work and how drugs like finasteride inhibit them, which could help in creating new drugs.

A circular RNA helps cashmere goat hair cells become hair follicles by blocking a molecule to boost a gene important for hair growth.

More research is needed to confirm the long-term effects of oral drugs for chronic central serous chorioretinopathy.

A rare case of a transplant patient developing a skin condition linked to HPV-49.

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Certain genetic variants impair enzyme activity, contributing to non-classic congenital adrenal hyperplasia.

A patient with a new PLEC gene mutation showed symptoms of both muscular dystrophy and myasthenia gravis, which improved with steroid treatment.

Sebaceous glands are often preserved and PPARy expression is constant in some cases of Central Centrifugal Cicatricial Alopecia.

Stiripentol shows promise as a potential treatment for androgen-related diseases but needs more testing.

Recombinant thrombomodulin can effectively treat severe complications in Cronkhite-Canada syndrome.

Very-long-chain acyl-CoA synthetases and fatty acid transport proteins play key roles in fatty acid metabolism and lipid processing in different tissues.

Sonidegib and vismodegib are similarly effective for advanced basal cell carcinoma, but sonidegib might have a slightly better safety profile.

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Drug misuse can cause serious eye infections and other severe side effects.

Cortisol increases a specific protein in bone cells, which may help explain its negative effects on bone.

The PIP5K1A gene helps cashmere growth in goats by promoting cell proliferation, and melatonin boosts its expression.

A new sustainable polyester is tough, recyclable, biodegradable, and aids wound healing, supporting a circular economy.

Impaired ABCA5 activity disrupts cholesterol balance in hair follicle cells, affecting hair growth.

Fibre optic confocal imaging can visualize skin layers, blood vessels, and nerves in live mice.

The chemical peel improved the appearance of hand spots safely and effectively.

Cyperus rotundus essential oil effectively treats underarm darkening, reduces inflammation, and slows hair growth.

A liver transplant patient with APECED had a rare VZV recurrence and pneumonia, treated successfully, but later died from other infections.

Finasteride may help treat chronic CSC, improving vision.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Citral increases sebaceous gland activity in male rats.

A woman's mature cystic teratoma caused her virilization by producing testosterone.