research In vivo alteration of the keratin 17 gene in hair follicles by oligonucleotide‐directed gene targeting
Altering the keratin 17 gene in mice hair follicles caused temporary hair issues, but changes were minimal and short-lived.
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810-840 / 1000+ resultsresearch Transcriptome-guided development of a fibrosis-reversal compound reduces skin scarring and allows regeneration via mitochondrial uncoupling
FR-1 reduces skin scarring and promotes healing without harmful effects.
research Determination of rat 5α-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines
New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.
research Strontium Ranelate Promotes Chondrogenesis Through Inhibition of the Wnt/β-catenin Pathway
Strontium ranelate helps cartilage growth by blocking a specific cell pathway.
research Solubilizing steroidal drugs by β-cyclodextrin derivatives
Using β-cyclodextrin derivatives improves the solubility and bioavailability of steroidal drugs.
research Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice
research Structural basis for the catalysis and inhibition of human steroid 5α‐reductase 2
The research gives new understanding on how human steroid 5α-reductases work and how drugs like finasteride inhibit them, which could help in creating new drugs.
research Treatment of multiple scalp basal cell carcinomas by photodynamic therapy
Photodynamic therapy was effective in treating multiple scalp basal cell carcinomas with minimal side effects and good cosmetic results.
research Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications
Melatonin-loaded nanocarriers improve melatonin delivery and effectiveness for various medical treatments.
research 576 INTASYL PH-762: Intratumoral immunotherapy targeting PD-1
PH-762 shows promise in treating skin cancer by effectively targeting and silencing PD-1 in tumors with minimal side effects.
research Germacrene Analogs are Anti-androgenic on Androgen-dependent Cells
Germacrene analogs, especially 8-Hydroxy germacrene B, are more effective than germacrone at blocking a hormone-related enzyme and could help treat hair loss.
research Transcriptome analyses of reprogrammed feather / scale chimeric explants revealed co-expressed epithelial gene networks during organ specification
Key genes can rewire networks, changing skin appendage types.
research Bioactive metabolites of edible mushrooms efficacious against androgenic alopecia: Targeting SRD5A2 using computational approach
Certain compounds found in edible mushrooms may help treat hair loss.
research Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment
Plant-based compounds might be effective, low-side-effect treatments for prostate cancer by blocking a specific enzyme.
research The lipide composition of epidermis and dermis of mice undergoing carcinogenesis by methylcholanthrene.
Cholesterol and phospholipids increase in mouse skin during cancer development, with differences between male and female skin.
research Anti-androgenic curcumin analogues as steroid 5-alpha reductase inhibitors
Some curcumin-like compounds can effectively and safely block the enzyme linked to hair loss and other conditions related to male hormones.
research Exploring the new horizons of drug repurposing: A vital tool for turning hard work into smart work
research Serendipity in Trichology
Accidental findings have led to new hair treatment discoveries, like using blood pressure and diabetes medications for hair loss and unwanted hair.
research Glucose-Activated Nanoreactor Initiating Cascade Reaction to Remodel Immune Microenvironment for Promoting Diabetic Wound Healing
MCP@G improves diabetic wound healing by reducing stress and promoting tissue repair.
research Deferasirox, an oral iron chelator, prevents hepatocarcinogenesis and adverse effects of sorafenib
Deferasirox combined with sorafenib reduces liver cancer risk and lessens treatment side effects.
research Nanocarriers for optimizing the balance between interfollicular permeation and follicular uptake of topically applied clobetasol to minimize adverse effects
Nanocapsules can improve clobetasol delivery to hair follicles, reducing side effects.
research Multiple crosslinked, self-healing, and shape-adaptable hydrogel laden with pain-relieving chitosan@borneol nanoparticles for infected burn wound healing
The hydrogel effectively treats infected burn wounds by reducing pain and preventing infection.
research Dutasteride/finasteride
research Abstract P5-11-11: A phase I safety study of topical calcitriol (BPM31543) for the prevention of chemotherapy-induced alopecia (CIA)
Topical calcitriol appears safe and may reduce hair loss during chemotherapy.
research Lignans and Neolignans: Plant secondary metabolites as a reservoir of biologically active substances
Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.
research Fully automated chip-based nanoelectrospray ionization-mass spectrometry as an effective tool for rapid and high-throughput screening of 5α-reductase inhibitors
research Antroquinonol Exerts Immunosuppressive Effect on CD8+ T Cell Proliferation and Activation to Resist Depigmentation Induced by H2O2
Antroquinonol may help prevent skin depigmentation by suppressing certain immune cells.
research Novel anti-aging gene NM_026333 contributes to proton-induced aging via NCX1-pathway
The gene NM_026333 slows down aging by affecting the NCX1 pathway and could be targeted for anti-aging treatments.
research Foreword
The birth control pill containing ethinylestradiol and chlormadinone may help treat acne and other skin and hair conditions related to hormones.
research Eclipta prostrata (L.) L. (uses and bioactivities)
Eclipta prostrata has many health benefits, including protecting the liver, fighting cancer, and reducing inflammation.