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GlossaryCholesterol Metabolism

body's process of producing, using, and breaking down cholesterol

Cholesterol metabolism refers to the processes by which the body synthesizes, utilizes, and breaks down cholesterol. This includes the production of cholesterol in the liver, its incorporation into cell membranes, its conversion into bile acids for digestion, and its removal from the body. Proper cholesterol metabolism is crucial for maintaining cellular function and overall health, and imbalances can lead to conditions such as cardiovascular disease.

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Molecular Phenotyping of Lichen Planopilaris Revealed Dysregulation of Cholesterol/Fatty Acid Metabolism, Fibrosis, and Mast Cell Pathways

research 923 Molecular phenotyping of lichen planopilaris revealed dysregulation of cholesterol/fatty acid metabolism, fibrosis and mast cell pathways

April 2019 in “Journal of Investigative Dermatology”

Lichen planopilaris involves disrupted fat metabolism, increased scarring, and mast cell activity.

research Coronavirus Infection and Cholesterol Metabolism

55 citations , April 2022 in “Frontiers in Immunology”

Cholesterol affects coronavirus spread and could be a target for treatment.

Low Sex Hormone-Binding Globulin Is Associated With Low High-Density Lipoprotein Cholesterol And Metabolic Syndrome In Women With Polycystic Ovary Syndrome

research Low sex hormone-binding globulin is associated with low high-density lipoprotein cholesterol and metabolic syndrome in women with PCOS

71 citations , June 2006 in “Human Reproduction”

Women with PCOS who have low SHBG are more likely to have low good cholesterol and metabolic syndrome.

research 24-Hydroxycholesterol suppresses steroid 5α-reductase-catalyzed conversion in human glioblastoma cell lines: A novel link between brain cholesterol homeostasis and androgen metabolism

January 2026 in “Neurochemistry International”

24-Hydroxycholesterol reduces DHT formation in brain cancer cells, linking cholesterol and hormone metabolism.

research Cholesterol homeostasis: Links to hair follicle biology and hair disorders

25 citations , July 2019 in “Experimental Dermatology”

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

research Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and Scd1 and Soat1 Activity

24 citations , July 2018 in “Stem cells”

Runx1 controls fat-related genes important for normal and cancer cell growth, affecting skin and hair cell behavior.

research 863 Central centrifugal cicatricial alopecia gene expression analysis revealed cholesterol, fatty acid, and mast cell pathways

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Targeting cholesterol, fatty acids, fibrosis, and mast cells may help treat CCCA.

research Cutaneous Androgen Metabolism: Basic Research and Clinical Perspectives

233 citations , November 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

research Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice

23 citations , February 2020 in “PLOS genetics”

Mice with LSS deficiency showed hair loss and cataracts, similar to humans, and can help in understanding and treating this condition.

research Androgenetic alopecia, metabolic syndrome, and insulin resistance: Is there any association? A case-control study

34 citations , January 2014 in “Indian Dermatology Online Journal”

Hair loss linked to metabolic issues and insulin resistance; early assessment may reduce future health risks.

research Persistent Poor Metabolic Profile in Postmenopausal Women With Ovarian Hyperandrogenism After Testosterone Level Normalization

8 citations , April 2019 in “Journal of the Endocrine Society”

Postmenopausal women with hyperandrogenism didn't have better metabolic health even after their testosterone levels became normal.

The Differences Between Aromatizable And Non-Aromatizable Androgens In Relation To Body Composition And Metabolic Syndrome Risk Factors In Men

research The differences between aromatizable and non-aromatizable androgens in relation to body composition and metabolic syndrome risk factors in men

8 citations , March 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

Testosterone and dihydrotestosterone have similar effects on body composition and metabolic health in men.

research Effect of an oral probiotic formula on scalp and facial skin condition, glucose, and lipid metabolism

1 citations , July 2022 in “Functional foods in health and disease/Journal of functional foods in health & disease”

Taking a probiotic supplement twice a day improved hair growth, skin hydration, and metabolic health in adults at risk of metabolic syndrome.

Evaluation of Metabolic and Hormonal Parameters in Women with PCOS Living in the Black Sea Region

research Evaluation of metabolic and hormonal parameters in women with PCOS living in Black Sea Region

1 citations , April 2021 in “Deneysel ve klinik tıp dergisi/Journal of experimental and clinical medicine”

Women with PCOS have a higher risk of metabolic syndrome and need lifestyle changes and treatment.

research Finasteride delays atherosclerosis progression in mice and is associated with a reduction in plasma cholesterol in men

January 2024 in “Journal of lipid research”

Finasteride may lower cholesterol and slow heart disease progression.

The Prevalence of Metabolic Disorders in Various Phenotypes of Polycystic Ovary Syndrome: A Community-Based Study in Southwest Iran

research The prevalence of metabolic disorders in various phenotypes of polycystic ovary syndrome: a community based study in Southwest of Iran

53 citations , September 2014 in “Reproductive Biology and Endocrinology”

Different types of PCOS have different levels of metabolic problems, with the most severe type showing the highest disturbances.

research Benign prostatic hyperplasia, metabolic syndrome and androgenic alopecia: Is there a possible relationship?

7 citations , February 2016 in “Arab journal of urology”

People with early hair loss may have a higher chance of enlarged prostate and metabolic syndrome, so they should be checked for urinary and metabolic issues.

research Cutaneous Correlates of Metabolic Syndrome and Its Components In Ogbomoso, Nigeria

5 citations , January 2018 in “JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH”

Flat feet in obese individuals may indicate metabolic syndrome.

The Association Between Metabolic Syndrome Components and Hair Loss in Both Male and Female Individuals

research The Association between Metabolic Syndrome Components and Hair Loss both Male and Female Individuals

2 citations , January 2013 in “Hair therapy & transplantation”

Hair loss may signal metabolic problems and increased risk of heart disease, suggesting people with hair loss should be checked for these issues.

research Association of Androgenic Alopecia with Metabolic Syndrome

1 citations , January 2018 in “Annals of Medical and Health Sciences Research”

People with male pattern baldness are more likely to have metabolic syndrome.

research IL6 is correlated with metabolic syndrome parameters in oral lichen planus

November 2015

IL6 is linked to higher risk of heart disease in people with a certain mouth condition.

research Risks for metabolic syndrome and cardiovascular diseases in both male and female patients with androgenetic alopecia

July 2015 in “Egyptian Journal of Dermatology and Venereology”

People with androgenetic alopecia, both men and women, are more likely to develop heart diseases in the future.

research Therapeutic approach for metabolic disorders and infertility in women with PCOS

54 citations , August 2017 in “Gynecological Endocrinology”

Lifestyle changes and weight loss are key for treating PCOS-related metabolic issues and infertility, with various medications available for specific symptoms.

research Is early onset androgenic alopecia a marker of metabolic syndrome and carotid artery atherosclerosis in young Indian male patients?

24 citations , January 2015 in “International Journal of Trichology”

Early balding in young Indian men may indicate a higher risk of metabolic syndrome and potential heart disease.

research Changes of metabolic profile in men treated for androgenetic alopecia with 1 mg finasteride

24 citations , January 2010 in “Endocrine Regulations”

Taking 1mg of finasteride daily can mildly improve metabolic health and glucose regulation in men with male pattern baldness.

Relationships Between Biochemical Markers of Hyperandrogenism and Metabolic Parameters in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

research Relationships Between Biochemical Markers of Hyperandrogenism and Metabolic Parameters in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

22 citations , January 2019 in “Hormone and Metabolic Research”

Measuring certain hormones can help predict metabolic risk in women with PCOS.

Metabolic Syndrome – A New Definition and Management Guidelines: A Joint Position Paper by Various Polish Medical Societies

research Metabolic syndrome – a new definition and management guidelines A joint position paper by the Polish Society of Hypertension, Polish Society for the Treatment of Obesity, Polish Lipid Association, Polish Association for Study of Liver, Polish Society of Family Medicine, Polish Society of Lifestyle Medicine, Division of Prevention and Epidemiology Polish Cardiac Society, “Club 30” Polish Cardiac Society, and Division of Metabolic and Bariatric Surgery Society of Polish Surgeons

20 citations , August 2022 in “Archives of Medical Science”

The Polish medical societies have redefined metabolic syndrome and recommend lifestyle changes, certain medications, and possibly bariatric surgery for treatment. They also discuss managing related health conditions.

Age-Related Differences in the Reproductive and Metabolic Implications of Polycystic Ovarian Syndrome: Findings in an Obese, United States Population

research Age-related differences in the reproductive and metabolic implications of polycystic ovarian syndrome: findings in an obese, United States population

16 citations , April 2012 in “Gynecological Endocrinology”

Older obese women with PCOS have higher cardiovascular and metabolic risks despite lower androgen levels.

research Raising threshold for diagnosis of polycystic ovary syndrome excludes population of patients with metabolic risk

14 citations , July 2016 in “Fertility and Sterility”

Changing the diagnosis criteria for PCOS might miss women at risk for related health issues.

research Menstrual Cycle Alterations during Adolescence: Early Expression of Metabolic Syndrome and Polycystic Ovary Syndrome

14 citations , September 2014 in “Journal of Pediatric and Adolescent Gynecology”

Irregular menstrual cycles in teenagers are linked to a higher risk of polycystic ovary syndrome and metabolic syndrome.