April 2023 in “Journal of Investigative Dermatology” Melatonin may help prevent hair loss caused by the chemotherapy drug paclitaxel.
9 citations
,
September 2020 in “Journal of cosmetic dermatology” A woman developed vitiligo from repeated eyebrow microblading.
Retinoids can help treat skin pigmentation disorders by affecting melanin production.
December 2025 in “Journal of Advanced Biotechnology and Experimental Therapeutics” Mesenchymal stem cells may help reduce melanin in UV-exposed mice.
9 citations
,
June 2017 in “American journal of ophthalmology. Case reports” A new mutation in the CDH3 gene causes hair loss and vision problems in a young girl.
60 citations
,
August 2005 in “Endocrinology” αMSH may help regulate immune responses in hair follicles and its disruption could lead to hair loss.
3 citations
,
June 2025 in “Stem Cell Research & Therapy” Hair follicle-derived melanocyte transplant could effectively treat vitiligo by restoring skin color.
March 2009 in “Chinese Journal of Dermatology” Melanocytes in the outer root sheath are likely stem cells that grow fast but stay immature.
Melatonin may protect hair follicle stem cells from damage caused by chemotherapy.
164 citations
,
February 2010 in “Journal of Cell Science” Human dermal stem cells can become functional skin pigment cells.
41 citations
,
April 2019 in “PLOS genetics” CD34+ and CD34- melanocyte stem cells have different regenerative abilities.
17 citations
,
May 2018 in “Journal of Biomedical Optics” Certain types of human hair might help ultraviolet rays reach and damage cells, possibly leading to melanoma.
January 2014 in “한국미용학회지” UV-A radiation significantly damages semi-permanent dyed hair.
3 citations
,
May 2020 in “Acta pharmaceutica” Protocatechuic acid can reduce melanin production and boost antioxidant activity in hair follicles.
15 citations
,
November 2018 in “Current radiopharmaceuticals” Melatonin can help prevent and treat skin damage caused by gamma rays.
April 2018 in “Journal of Investigative Dermatology” Different types of stem cells in the skin contribute to the variety of melanoma forms.
303 citations
,
August 1971 in “The American Journal of Medicine” Melanocytes are destroyed by factors needed for melanin production, causing vitiligo and gray hair.
30 citations
,
December 2001 in “Experimental dermatology” Gonadal hormones significantly affect the severity of alopecia areata in mice.
27 citations
,
May 2024 in “Clinical and Translational Medicine” Melanocyte stem cells are vital for skin and hair color and have potential in treating skin disorders and cancer.
April 2019 in “Institutional Repositories DataBase (IRDB)” Patient-derived stem cell melanocytes could be a promising treatment for vitiligo.
27 citations
,
August 2006 in “Laboratory Investigation” SCF and ET-1 together significantly increase skin pigmentation and melanin production.
13 citations
,
April 2022 in “Frontiers in oncology” Melanoma development can be linked to the breakdown of skin's melanin-producing units.
15 citations
,
March 2015 in “Experimental Dermatology” Clotrimazole, an antifungal cream, may safely reduce skin pigmentation by breaking down the enzyme needed for making melanin.
12 citations
,
December 1981 in “Journal of Endocrinology” α-MSH increases melanin production in moulting hair follicles, while AVT inhibits it.
2 citations
,
March 2023 in “JAAD case reports” Hair repigmentation can indicate malignancy and should be investigated.
1 citations
,
January 2015 in “Journal of Pigmentary Disorders” Melasma is a skin condition linked to female hormones, genetics, UV exposure, and certain medications, but not to pituitary, adrenal, or thyroid diseases.
57 citations
,
April 2009 in “Differentiation” SDF-1/CXCL12 and its receptor CXCR4 are crucial for melanocyte movement in mouse hair follicles.
Hair turning darker can be a sign of skin cancer.
15 citations
,
June 1986 in “Pediatric Dermatology” Androgens increase pigmentation in young hamsters, but estrogens can reverse this effect.
7 citations
,
March 2003 in “PubMed” The scalp has a natural speckled pattern of increased pigment around hair follicles, possibly linked to local hormone production.