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Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Early diagnosis and multidisciplinary care are crucial for managing CNOT3 syndrome.

Certain mutations in the KLHL24 gene cause a skin disorder by breaking down an important skin protein.

Clofazimine may be effective for treating ashy dermatosis.

The enzyme 17β-HSD type 2 mainly performs oxidation in human sebaceous glands, which may help protect against acne.

The research found that polycystic ovary syndrome (PCOS) has two distinct types, with one having more severe hormone and insulin issues.

Minoxidil affects collagen-related genes, potentially helping treat fibrosis.

Researchers found genetic mutations causing hypohidrotic ectodermal dysplasia in 88% of studied patients and identified new mutations and genetic variations affecting the disease.

Men have more severe COVID-19 outcomes than women.

Certain drugs that block specific enzymes can help treat prostate diseases.

Sex hormones may affect COVID-19 severity, with men often faring worse, and targeting related pathways could offer treatment options.

Hirsute women have lower type 2 17β-HSD enzyme levels, which improve with treatment.

PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.

Gene differences may affect baldness treatment response in Korean men.

Genetic differences affect COVID-19 severity and treatment effectiveness.

Most children with a common hemochromatosis genotype had elevated iron levels but no severe symptoms.

FLCN helps control iron levels in cells.

Certain gene variations may increase the risk and severity of alopecia areata.

Post-COVID-19 syndrome is complex, affects 5%-10% of people, and requires better research and global collaboration for treatment.

Azathioprine may help treat Alopecia Areata.

Patients with a specific genetic variant have more severe alopecia areata and higher recurrence rates.

Glycogen metabolism is important for energy and processes in human hair follicles, and hair follicles may produce glucose from lactate.

Stabilizing HIF1A in hair follicles increases glycolysis, which may help reduce oxidative stress and support hair growth.

Hair follicle stem cells can change their role to ensure proper hair development.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

1α,25-dihydroxyvitamin D3 directly affects cartilage growth and development.

Consider NF1 in newborns with rare congenital anomalies.

A new genetic region, 17q21.31, is linked to higher ovarian cancer risk.