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GlossaryChromosome 17

contains genes crucial for cell growth and DNA repair

Chromosome 17 is one of the 23 pairs of chromosomes in humans and contains approximately 83 million base pairs, which represent about 2.5% of the total DNA in cells. It is notable for housing several important genes, including those related to the production of proteins involved in cell growth, DNA repair, and the development of the nervous system. Mutations or alterations in genes on Chromosome 17 can lead to various medical conditions, such as certain types of cancer and neurological disorders.

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The Human Type I Keratin Gene Family: Characterization of New Hair Follicle Specific Members and Evaluation of the Chromosome 17q21.2 Gene Domain

research The human type I keratin gene family: Characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain

70 citations , December 2004 in “Differentiation”

The study identified and characterized new keratin genes linked to hair follicles and epithelial tissues.

research Genomic Organization and Amplification of the Human Keratin 15 and Keratin 19 Genes

12 citations , January 2000 in “Biochemical and Biophysical Research Communications”

The study mapped keratin 15 and 19 genes, aiding future genetic disorder research.

research Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases

January 2012 in “Faculty of Health; Institute of Health and Biomedical Innovation”

Early-onset hair loss is linked to Parkinson's disease and decreased fertility.

Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

research Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 2111In fond memory of Dr Peter Steinert.

62 citations , January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.

research Whole-genome SNP genotyping mapped a novel locus for hereditary hypotrichosis on chromosome 2q31.1–q32.2

May 2015 in “Journal of Dermatological Science”

Researchers found a new area on chromosome 2 linked to a genetic hair loss condition.

research Two mouse mutations mapped to chromosome 11 with differing morphologies but similar progressive inflammatory alopecia

7 citations , May 2005 in “Experimental Dermatology”

Two mouse mutations cause similar hair loss despite different skin changes.

research Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31

106 citations , March 2013 in “Nature Communications”

A new genetic region, 17q21.31, is linked to higher ovarian cancer risk.

research Genome-wide association study identifies a new locus JMJD1C at 10q21 that may influence serum androgen levels in men

78 citations , August 2012 in “Human molecular genetics online/Human molecular genetics”

A new gene, JMJD1C, may affect testosterone levels in men.

research Characterization of a First Domain of Human High Glycine-Tyrosine and High Sulfur Keratin-associated Protein (KAP) Genes on Chromosome 21q22.1

100 citations , December 2002 in “Journal of biological chemistry/The Journal of biological chemistry”

Researchers mapped and categorized specific keratin-associated protein genes on human chromosome 21q22.1.

research Dissection of genetic variation and evidence for pleiotropy in male pattern baldness

58 citations , December 2018 in “Nature Communications”

Male pattern baldness is mostly inherited, involves many genes, and is linked to other traits like early puberty and strong bones.

research Prediction of male-pattern baldness from genotypes

37 citations , October 2015 in “European Journal of Human Genetics”

Genetic data can predict male-pattern baldness with moderate accuracy, especially for early-onset cases in some European men.

research Hunting the genes in male‐pattern alopecia: how important are they, how close are we and what will they tell us?

46 citations , February 2016 in “Experimental Dermatology”

Genes play a significant role in male-pattern baldness, and understanding them could lead to new treatments and insights into related health issues.

research Sex-limited chromosomes and non-reproductive traits

10 citations , July 2022 in “BMC Biology”

Sex-limited chromosomes can affect traits not related to reproduction.

research Human KAP Genes, Only the Half of it? Extensive Size Polymorphisms in Hair Keratin-Associated Protein Genes

53 citations , June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

KAP genes show significant genetic variability, but its impact on hair traits is unclear.

research The Complexity of the Ovine and Caprine Keratin-Associated Protein Genes

10 citations , November 2021 in “International journal of molecular sciences”

Sheep and goat hair fibers are complex due to keratin-associated proteins, which are important for fiber properties and growth.

research Genetic and molecular aspects of androgenetic alopecia

24 citations , January 2018 in “Indian Journal of Dermatology, Venereology and Leprology”

Androgenetic alopecia is mainly caused by genetic factors and increased androgen activity, leading to hair follicle miniaturization.

research Androgenetic Alopecia in Men: An Update On Genetics

May 2024 in “Indian Journal of Dermatology”

Androgenetic alopecia in men is genetic and linked to health issues like obesity and heart disease, with treatments including minoxidil, finasteride, and hair transplants.

Recurrent Pregnancy Loss Associated with Cytogenetic and Genetic Anomalies: A Study from Eastern India

research Recurrent Pregnancy Loss Associated Cytogenetic and Genetic Anomalies – Study from Eastern India

2 citations , March 2024 in “International Journal of experimental research and review”

Genetic variations contribute to over 10% of recurrent early pregnancy loss cases.

Novel circRNAs From Cashmere Goats: Discovery, Integrated Regulatory Network, and Their Putative Roles in the Regeneration and Growth of Secondary Hair Follicles

research Novel circRNAs from cashmere goats: Discovery, integrated regulatory network, and their putative roles in the regeneration and growth of secondary hair follicles

7 citations , June 2022 in “Czech Journal of Animal Science”

Certain circular RNAs help cashmere goats grow more hair.

research Cicatricial alopecia: What’s new in etiology?

November 2015 in “European Journal of Inflammation”

Cicatricial alopecia, a permanent hair loss condition, is mainly caused by damage to specific hair follicle stem cells and abnormal immune responses, with gene regulator PPAR-y and lipid metabolism disorders playing significant roles.

research Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing

60 citations , July 2020 in “ACS Nano”

Using CRISPR for gene editing in the body is promising but needs better delivery methods to be more efficient and specific.

research Unraveling the complex role of MAPT-containing H1 and H2 haplotypes in neurodegenerative diseases

26 citations , May 2024 in “Molecular Neurodegeneration”

H1 increases risk for neurodegenerative diseases, while H2 offers protection but is linked to other disorders.

research Terrestrial vertebrates have two keratin gene clusters; striking differences in teleost fish

47 citations , July 2005 in “European Journal of Cell Biology”

Terrestrial vertebrates have balanced keratin gene clusters, unlike teleost fish.

research Human Hair Keratin‐Associated Proteins (KAPs)

226 citations , January 2006 in “International review of cytology”

Keratin-associated proteins are crucial for hair strength and structure.

research Wool Keratin-Associated Protein Genes in Sheep—A Review

98 citations , May 2016 in “Genes”

Understanding wool keratin-associated proteins in sheep can help improve wool quality through selective breeding.

research Characterization of Hair Follicles in Hirosaki Hairless Rats with Deletion of Basic Hair Keratin Genes. Enlarged Medulla, Loss of Cuticle and Long Catagen

3 citations , March 2009 in “Hirosaki University Repository for Academic Resources (Hirosaki University)”

Hirosaki hairless rats have sparse, twisted hair due to missing hair keratin genes.

research Polymorphisms and association of FAT1 gene with wool quality traits in Chinese Merino sheep

6 citations , January 2020 in “Czech Journal of Animal Science”

The FAT1 gene and its variations can help improve wool quality in Chinese Merino sheep through selective breeding.

research What does acne genetics teach us about disease pathogenesis?

29 citations , March 2019 in “British Journal of Dermatology”

Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.

research A systematic review of clinical trials using single or combination therapy of oral or topical finasteride for women in reproductive age and postmenopausal women with hormonal and nonhormonal androgenetic alopecia

March 2023 in “Advances in Clinical and Experimental Medicine”

Oral and topical finasteride are effective and safe for treating female hair loss.

research Mutations in the Keratin 85 (KRT85/hHb5) Gene Underlie Pure Hair and Nail Ectodermal Dysplasia

42 citations , October 2009 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mutations in the KRT85 gene cause hair and nail problems.