92 citations
,
August 2017 in “Proceedings of the National Academy of Sciences of the United States of America” Newborn mouse skin cells can grow hair and this process can be recreated in adult cells to potentially help with hair loss.
81 citations
,
June 2012 in “European journal of human genetics” Inherited ichthyoses cause widespread skin scaling and thickening due to gene mutations.
50 citations
,
March 2021 in “Journal of investigational allergology & clinical immunology” Dupilumab is being tested for many new skin, respiratory, and gastrointestinal conditions.
43 citations
,
December 2013 in “Seminars in Cell & Developmental Biology” Genetic mutations can cause hair growth disorders by affecting key genes and signaling pathways.
39 citations
,
August 2018 in “Scientific reports” Claudin-1 is important for the barrier function and growth of hair.
36 citations
,
January 2021 in “Scientific Reports” Key genes and pathways, including Wnt, NF-Kappa, and JAK-STAT, are crucial for starting Pashmina fiber growth in goats.
28 citations
,
July 2007 in “Development” TAF4 is important for skin cell growth and helps prevent skin cancer in mice.
26 citations
,
October 2017 in “Clinical Reviews in Allergy & Immunology” Autoimmune liver diseases are likely linked to certain skin conditions like vitiligo and psoriasis.
22 citations
,
April 2020 in “Scientific reports” Changthangi goats have specific genes that help produce Pashmina wool.
13 citations
,
July 2022 in “Frontiers in cell and developmental biology” Tiny natural vesicles from cells might help treat hair loss.
13 citations
,
May 2022 in “Cell discovery” The study found new details about human hair growth and suggests that preventing a specific biological pathway could potentially treat hair graying.
11 citations
,
January 2018 in “Acta dermato-venereologica” Researchers found specific genes in the part of hair follicles that could help treat hair disorders.
10 citations
,
November 2022 in “Protein & Cell” Quercetin significantly helps hair growth by activating hair follicles and improving blood vessel formation around them.
9 citations
,
March 2018 in “European journal of dermatology/EJD. European journal of dermatology” A new mutation in the ST14 gene causes a rare skin and hair disorder in a specific family.
8 citations
,
November 2017 in “Journal of Investigative Dermatology” AGA linked to inflammation, stress, fibrosis, and disturbed hair follicle stem cells.
7 citations
,
October 2018 in “BMC genomics” Key genes can rewire networks, changing skin appendage types.
5 citations
,
January 2024 in “The International Journal of Developmental Biology” Mouse models help target specific genes in lymphatic cells for research.
4 citations
,
December 2013 in “Acupuncture and related therapies” N-acetyl-cysteine shows promise in treating various diseases and may improve skin and hair conditions, but more research is needed on dosages and long-term effects.
3 citations
,
October 2024 in “Frontiers in Medicine” Sun-exposed skin shows different cell activity and gene expression, suggesting targets to prevent skin aging and cancer.
3 citations
,
December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” The research reveals how early embryonic mouse skin develops from simple to complex structures, identifying various cell types and their roles in this process.
2 citations
,
March 2022 in “Portuguese Journal of Nephrology & Hypertension” A rare EGFR mutation in newborns leads to severe health issues and early death.
2 citations
,
April 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” The conclusion is that analyzing RNA from skin oils is a promising way to understand skin diseases.
1 citations
,
April 2018 in “Journal of Investigative Dermatology” Oleoylethanolamide (OEA) safely boosts fat production in skin cells and may help treat dry skin and reduce inflammation.
1 citations
,
February 2013 in “InTech eBooks” Genetic mutations cause various hair diseases, and whole genome sequencing may reveal more about these conditions.
1 citations
,
January 2021 CD4+ skin cells may be precursors to basal cell carcinoma.
1 citations
,
January 2018 in “Stem cell biology and regenerative medicine” DNA methylation is essential for skin and hair follicle development, and could be a target for treating skin diseases.
1 citations
,
May 2017 in “InTech eBooks” Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.
Hair follicle-derived sheets can effectively treat vitiligo by repigmenting skin.
Menopause-related skin changes may increase fungal infections and inflammation.
PmtHEE is a better model for studying pigmented skin because it includes melanocytes and shows improved cell differentiation.