research Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis
Merkel cells stabilize nerve endings in the skin, and they change independently of each other.
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research Newly born mesenchymal cells disperse through a rapid mechanosensitive migration
Newly born mesenchymal cells quickly spread out in response to tissue tension during early development.
research MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells
MicroRNA-205 helps hair grow by changing the stiffness and contraction of hair follicle cells.
research Improved humoral immunity and protection against influenza virus infection with a 3D porous biomaterial vaccine
The new vaccine platform led to a stronger immune response and better protection against the flu than the traditional vaccine.
research Inferring Spatially Resolved Transcriptomics Data from Whole Slide Images for the Assessment of Colorectal Tumor Metastasis: A Feasibility Study
Using deep learning to predict gene expression from images could help assess colorectal cancer metastasis.
research Prostaglandin E2 prevents radiotherapy-induced alopecia by attenuating transit amplifying cell apoptosis through promoting G1 arrest
Prostaglandin E2 helps prevent hair loss from radiotherapy by protecting hair cells.
research MOF-mediated Histone H4 Lysine 16 Acetylation Governs Mitochondrial and Ciliary Functions By Controlling Gene Promoters
MOF controls skin development by regulating genes for mitochondria and cilia.
research Transcriptomic landscape of early hair follicle and epidermal development
Researchers identified new cell types and genes in early hair follicle development.
research Mechanisms of vascular maturation and maintenance captured by longitudinal imaging of live mouse skin
Neonatal blood vessels rearrange and stabilize as adults, with adult vessels better at self-repair after injury.
research Genetic and histological correlation between the musk gland and skin of Chinese forest musk deer
Musk glands and skin in Chinese forest musk deer are closely related and share many genes.
research Kinetics of blood cell differentiation during hematopoiesis revealed by quantitative long-term live imaging
Small changes in cell division and differentiation can activate blood progenitors.
research Integrated single-cell chromatin and transcriptomic analyses of human scalp reveal etiological insights into genetic risk for hair and skin disease
The research provided new insights into the genetic factors contributing to hair loss and skin conditions by analyzing individual cells from the human scalp.
research A helminth mimic of TGF-β, TGM, enhances regenerative cutaneous wound healing and modulates immune cell recruitment and activation
A parasite-derived molecule speeds up skin healing and affects immune cell behavior without increasing scarring.
research Staining of human skin with RGB trichrome unveils a proteoglycan-enriched zone in the hair dermal sheath
A new staining method shows a special area in the hair's skin layer with lots of proteoglycans.
research Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation
The Kras mutation changes normal cell signals, leading to disrupted tissue structure and potential cancer.
research Mediator 1 ablation induces enamel-to-hair lineage conversion through enhancer dynamics
Removing Mediator 1 causes teeth cells to turn into hair cells.
research Reorganizing Niche Architecture Still Preserves Organ Function in the Hair Follicle
Changing the structure of the hair follicle's environment can affect hair quality but doesn't stop hair growth.
research Evaluation of noninvasive biospecimens for transcriptome studies
Hair follicles and urine cell pellets are promising for transcriptome studies due to consistent quality and useful expression profiles.
research Medication Clusters at Hospital Discharge and Risk of Adverse Drug Events at 30-days Post-Discharge: A Population-based Cohort Study of Older Adults
Certain groups of medications given when leaving the hospital are linked to a higher risk of negative drug reactions within 30 days, especially in older adults with respiratory issues.
research A qualitative phase I study protocol on developing patient-reported outcome measure for hair, scalp, eyebrows, eyelashes, and beard-related skin disorders
The goal is to create a tool for patients to report their experiences with various hair and scalp disorders.
research Follicle-innervating Aδ-low threshold mechanoreceptors organize through a population-dependent mechanism
Mouse touch-sensitive nerve cells adjust their connections based on competition with other similar cells.
research An ERK-dependent molecular switch antagonizes fibrosis and promotes regeneration in spiny mice (Acomys)
A specific molecular switch, driven by MAPK/ERK signaling, helps spiny mice heal wounds by regenerating skin instead of forming scars.
research Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata
ILC1-like cells can cause alopecia areata by attacking hair follicles.
research A Role for Steroid 5 alpha-reductase 1 in Vascular Remodelling During Endometrial Decidualisation
The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.
research Blood group O and post-COVID-19 syndrome
People with blood group O may have a higher risk of developing post-COVID-19 syndrome.
research Signaling modality within gp130 receptor enhances tissue regeneration
The gp130 receptor helps in tissue regeneration and disease progression, and manipulating it could improve healing and prevent disease.
research 4-aminopyridine promotes accelerated skin wound healing via neurogenic-mediator expression
4-aminopyridine helps skin wounds heal faster and better.
research Single injection of very mild dose BOTOX in the vastus lateralis improves testicular spermatogenesis and sperm motility in ageing experimental mice
A small BOTOX dose improved sperm production and movement in older mice.
research The Hair Cell Analysis Toolbox: A machine learning-based whole cochlea analysis pipeline
The Hair Cell Analysis Toolbox automates and improves the analysis of cochlear hair cells using machine learning.
research Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury.
Special gut cells help stem cells move to and fix injured areas by activating a specific signaling pathway.