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The treatment successfully lowered testosterone levels and reduced symptoms.

Treating classic 21-hydroxylase deficiency requires precise glucocorticoid dosing and attention to individual patient needs, with new treatments showing promise.

Treating early puberty with hormone therapy may increase the risk of polycystic ovary syndrome in adults.

A woman with acromegaloidism and normal growth hormone levels had a rare X-Tetrasomy, suggesting a need to study X-chromosome genes for their role in growth and facial development.

New treatments for low male hormones improved sexual function and mood but had unclear risks, especially for older men.

Anastrozole and cyproterone acetate treatment can help increase adult height in boys with testotoxicosis.

Clomiphene citrate is a cheap and simple treatment for low testosterone that works as well as human chorionic gonadotropin, alone or combined, especially for men who want to keep their fertility.

Early physical exams are crucial for timely Klinefelter syndrome diagnosis.

Ovarian stromal hyperplasia can cause high testosterone in postmenopausal women and is treated by removing the ovaries.

Using GnRHa agonists helps diagnose and treat ovarian hyperthecosis when surgery isn't possible.

A 12-year-old girl with very high testosterone and insulin resistance improved with birth control pills, suggesting PCOS can cause high testosterone without tumors.

A multidisciplinary approach is crucial for safe and effective hormone treatment in gender-dysphoric individuals, with specific guidelines for adolescents and adults.

A 17-year-old female with adrenogenital syndrome produces very high levels of androgens, which prevent complete feminization despite high estrogen doses.

Testosterone replacement therapy can prevent men from fathering children and should not be used by those wanting to stay fertile.

A 13-year-old girl's masculine symptoms improved after surgery for a rare adrenal tumor that produced male hormones.

The statement offers guidance for hormone therapy and surgery to help gender-incongruent adults affirm a male identity.

A woman's severe male hormone excess was caused by a small, hard-to-find ovarian tumor.

5α-reductase-2 deficiency causes ambiguous genitalia at birth and affects male sexual development, but individuals often develop male characteristics at puberty.

Removing both ovaries can treat increased testosterone and related symptoms in postmenopausal women with ovarian hyperthecosis.

Treating Netherton syndrome with growth hormone and dupilumab improves growth safely.

A postmenopausal woman's masculine symptoms improved after surgery for a hormone-producing ovarian tumor.

Five new mutations in the androgen receptor gene were found, helping to understand androgen insensitivity syndrome better.

The man's fatigue and erectile dysfunction were improved by treating his obesity-related low testosterone without needing testosterone replacement.

A new genetic change causing early stop in the androgen receptor gene was found in a patient with androgen insensitivity syndrome.

Cantú syndrome may be linked to pituitary adenomas.

Early puberty is more common in girls and African-American children, possibly due to nutrition, obesity, stress, and environmental factors, and is treated with hormone therapy.

A 14-year-old girl with no menstrual period was diagnosed with Swyer Syndrome and treated for a related cancer risk.

A 36-year-old person with a female appearance but male chromosomes was diagnosed with a rare enzyme deficiency affecting sexual development.

"D-CHRAMPS syndrome" is a newly identified condition with multiple severe symptoms.

Most children with a common hemochromatosis genotype had elevated iron levels but no severe symptoms.