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Gender-affirming hormone therapy changes hair growth in transgender people, with feminizing therapy reducing hair and masculinizing therapy increasing it, but sometimes additional treatment is needed.

The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

c-Myc activation in mouse skin increases sebaceous gland growth and affects hair follicle development.

Myc activation reduces skin stem cells by affecting cell adhesion.

Retinoic acid-binding proteins in skin are regulated by β-catenin and Notch signalling.

In STSD patients, the body compensates for low androgen levels by increasing another enzyme's activity.

SRD5A1 is crucial in advanced prostate cancer, and blocking both SRD5A1 and SRD5A2 is more effective than targeting SRD5A2 alone.

Bidens pilosa L. extract effectively treats androgen deficiency dry eye in rats.

TNFα, IFNγ, and Substance P significantly affect prolactin levels in human skin, suggesting new treatments for skin and hair conditions.

Testosterone can help premenopausal and postmenopausal women with low sexual desire, but its long-term safety is unclear and it's not widely approved for this use.

VB-1, a natural compound, may promote hair growth by enhancing a key cell growth pathway.

Significant progress was made in understanding androgen excess disorders, but much is still unknown.

Higher levels of miR-1199-5p may reduce the effectiveness of certain prostate treatments.

Dihydroartemisinin helps reduce prostate enlargement in rats by stopping the growth of prostate cells.

A specific pathway involving AR, miR-221, and IGF-1 plays a key role in causing common hair loss.

Women have a higher DHT/testosterone ratio than men, possibly due to gut bacteria activity.

New CRISPR/Cas9 variants and nanotechnology-based delivery methods are improving cancer treatment, but choosing the best variant and overcoming certain limitations remain challenges.

Lifestyle changes and environmental strategies can help address declining testosterone levels.

Drug repurposing offers faster, cheaper drug development but faces challenges like safety, ethics, and funding.

Erosive pustular dermatosis in elderly people may be linked to aging immune systems and skin damage.

The guideline emphasizes a multidisciplinary approach and informed consent for gender-affirming hormone treatment, with regular follow-ups and individualized care.

Certain medications can cause gum problems, so patients and healthcare providers should be aware and monitor oral health.

Certain medications, including some immune drugs, contraceptives, and hair loss treatments, are often linked to hair loss.

Androgenic alopecia, a common hair loss condition, is linked to changes in androgen metabolism and genetics, and can be treated with finasteride and minoxidil, but these treatments are only fully effective in 10% of patients.

Gender-affirming hormone therapy improves mental health and gender incongruence but requires careful management of cardiovascular and cancer risks.

Testosterone therapy is effective and safe for women with low sexual desire, but it's hard to access.

Polyphenols in plant foods help prevent diseases and have potential uses in food, cosmetics, and more.

CRH in the skin acts like the body's stress response system, affecting cell behavior and immune activity.

Microneedles are effective for drug delivery, vaccinations, fluid extraction, and treating hair loss, with advancements in manufacturing like 3D printing.