research Expression and function of nuclear receptor co-activator 4: evidence of a potential role independent of co-activator activity
NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.
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750-780 / 1000+ results research The microanatomy of the distal arrector pili: possible role for α1β1 and α5β1 integrins in mediating cell‐cell adhesion and anchorage to the extracellular matrix
The arrector pili muscle attaches to the extracellular matrix using α5β1 integrin and connects muscle cells using α1β1 integrin.
research Disulfide Cross-Linked Network Structure of Intermediate Filament and Matrix in Hair and Wool Cortices
Hair and wool strength is affected by the number and type of bonds in their protein structures, with hair having more protein aggregates than wool.
research Deciphering gene regulatory programs in mouse embryonic skin through single-cell multiomics analysis
HT-scCAT-seq helps understand gene regulation in embryonic skin development.
research Integrated analysis of long non-coding RNA and mRNA expression in different colored skin of koi carp
The study conducted an integrated analysis of long non-coding RNA (lncRNA) and mRNA expression in the black, white, and red skin of Koi carp, identifying 92 differentially expressed lncRNAs and 722 mRNAs. It revealed complex co-expression networks, suggesting that lncRNAs played a significant role in skin pigmentation through pathways such as melanogenesis and tyrosine metabolism. The research highlighted specific lncRNAs and mRNAs involved in pigmentation, such as Ccr_lnc5622441 and Pmela, and explored their roles through Gene Ontology and KEGG pathway analyses. The findings provided insights into the genetic mechanisms of skin color in koi carp and expanded the understanding of lncRNA functions in fish, offering valuable resources for future research.
research Pitfalls of PCR-Based Strategy for Genotyping Cre-Loxp Mice
PCR genotyping in cre-loxP mice can be inaccurate due to unintended gene deletions in non-target tissues.
research Whole-transcriptome analysis reveals the profiles and roles of coding and non-coding RNAs during hair follicle cycling in Rex rabbits
Key genes and RNA networks regulate hair growth and follicle density in Rex rabbits.
research Activation of the OVOL1-OVOL2 axis in the hair bulb and in pilomatricoma and pilomatrix carcinoma
The OVOL1-OVOL2 axis is important for hair follicle differentiation and can help diagnose certain hair-related tumors.
research Three strands ironed closely together
A new method was developed to create complex molecular knots using iron ions.
research 647 Alternative splicing factor Esrp1 controls homeostasis of skins by regulating barrier formation and function
Esrp1 is important for skin health by helping form and maintain the skin barrier.
research Differential expression levels of Sox9 in early neocortical radial glial cells regulate the decision between stem cell maintenance and differentiation
Sox9 levels in brain stem cells affect whether they stay as stem cells or become neurons.
research The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice
Disrupting the Sox21 gene in mice causes hair loss and regrowth cycles.
research Exosomes and Stem Cells
research 085 Dermal papilla cells control hair follicle matrix keratinocytes proliferation through versican
Versican in dermal papilla cells is crucial for healthy hair growth.
research Characterization of a First Domain of Human High Glycine-Tyrosine and High Sulfur Keratin-associated Protein (KAP) Genes on Chromosome 21q22.1
Researchers mapped and categorized specific keratin-associated protein genes on human chromosome 21q22.1.
research Nevus comedonicus
Nevus comedonicus is a rare skin condition with grouped open pores, sometimes linked to other body issues.
research Electroosmotic pore transport in human skin.
research Peptide-Based PROTACs: Transitioning from Static Paradigm to a Dynamic Landscape within Targeted Protein Degradation
Peptide-based PROTACs show promise in targeting hard-to-treat proteins, especially for cancer therapy.
research Cell Type-specific Functions of the Lysosomal Protease Cathepsin L in the Heart
Cathepsin L is essential for heart health and its absence causes heart problems and hair loss.
research Orchestration of tissue‐scale mechanics and fate decisions by polarity signalling
Cell polarity signaling controls tissue mechanics and cell fate, with complex interactions and varying pathways across species.
research Corneal Endothelial Cell Fate Is Maintained by LGR5 Through the Regulation of Hedgehog and Wnt Pathway
LGR5 helps maintain corneal cell characteristics and prevents unwanted changes by controlling specific cell signaling pathways.
research Transcriptome sequencing reveals the expression profiles of lncRNAs and mRNAs in goat skin tissues with different types of wool coats
The study identified key genes and pathways that influence goat wool quality and growth.
research The Emerging Structural Pharmacology of ATP-Sensitive Potassium Channels
KATP channels are important for energy balance and are targeted by drugs for diabetes, hypoglycemia, hypertension, and hair loss.
research Identification of a human type XVII collagen fragment with high capacity for maintaining skin health
A fragment of human type XVII collagen shows great potential for skin health and wound healing.
research Chloroquine and cinchonine affect rat vascular smooth muscle tonus through calcium channels – in silico and in vitro approaches
Chloroquine and cinchonine relax rat blood vessels by affecting calcium channels, with chloroquine needing caution in heart patients.
research Proteoglycans and Associated Proteins of the Mammalian Hair Follicle
research Construction and Verification of Recombinant Follicle-specific Expression Vector
The vector successfully directed specific gene expression in hair follicles.
research Matrisomal components involved in regenerative wound healing in axolotl and Acomys: implications for biomaterial development
Certain genes are more active during wound healing in axolotl and Acomys, which could help develop materials that improve human wound healing and regeneration.
research Characterisation of Myotonic Dystrophy type I cell models and drug evaluation by a cell- based quantification platform.
Antisense oligonucleotides show promise for treating Myotonic Dystrophy type I.
research The fundamentals of WNT10A
WNT10A is important for tissue development and linked to various human disorders.