36 citations
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May 2017 in “The journal of sexual medicine” Cyproterone acetate treatment is safe and causes mild feminization, which increases with added estrogen.
2 citations
,
January 2012 in “PubMed” A gluten-free diet and surgery fixed the girl's calcium levels and started puberty.
54 citations
,
April 2010 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism” Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.
53 citations
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January 2006 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Reduced AR gene methylation may cause early pubic hair growth in girls.
April 2020 in “Journal of the Endocrine Society” A 14-year-old girl with no menstrual period was diagnosed with Swyer Syndrome and treated for a related cancer risk.
192 citations
,
January 1976 in “The Journal of Clinical Endocrinology & Metabolism” Androgen levels increase with puberty and are linked to sexual hair development.
April 2019 in “Journal of the Endocrine Society” A 31-year-old woman was diagnosed with Complete Androgen Insensitivity Syndrome much later than usual, leading to a call for earlier detection and treatment guidelines.
4 citations
,
August 2021 in “Pediatrics in review” DSDs are birth conditions causing unusual sex development, managed with personalized care and sometimes surgery, but still lack a standard treatment approach.
15 citations
,
April 2019 in “Best Practice & Research Clinical Endocrinology & Metabolism” Polycystic Ovary Syndrome (PCOS) in teenagers is a complex condition linked to genetics and environment, often associated with obesity and insulin resistance, and is treated with lifestyle changes and medication.
August 2025 in “Geburtshilfe und Frauenheilkunde” Adolescents with PCOS need tailored diagnosis and support, including lifestyle advice and managing related health issues.
75 citations
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June 1999 in “Pediatric Clinics of North America” The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.
5 citations
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February 2023 in “Journal of Clinical Medicine” Diagnosing and treating PCOS in teenagers is difficult, and the focus is on lifestyle changes and medication to improve health and prevent future issues.
A 22-year-old woman with a rare genetic condition was successfully treated to develop normal female characteristics and regular menstruation.
October 2013 in “The American Journal of Gastroenterology” Early diagnosis of colorectal cancer in young patients with certain symptoms is crucial for better outcomes.
January 2026 in “International Journal of Women s Health” A new model helps predict treatment success in girls with early puberty.
27 citations
,
October 2016 in “The Journal of Clinical Endocrinology and Metabolism” Daughters of women with PCOS generally experience normal puberty but may have more body hair and different body fat distribution.
August 2025 in “Journal of Pediatric Endocrinology and Metabolism” A rare ovarian tumor in a 2-year-old girl was successfully removed, normalizing her hormone levels.
71 citations
,
November 2009 in “Best Practice & Research in Clinical Obstetrics & Gynaecology” PCOS in teens is hard to diagnose, linked to genetics and lifestyle, and managed with weight loss and medication.
14 citations
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September 2014 in “Journal of Pediatric and Adolescent Gynecology” Irregular menstrual cycles in teenagers are linked to a higher risk of polycystic ovary syndrome and metabolic syndrome.
2 citations
,
April 2022 in “Annales d Endocrinologie” Recombinant gonadotropins improve future fertility in CHH patients.
34 citations
,
June 2010 in “Archives of Disease in Childhood” Menstrual disorders are common in adolescents and can be influenced by weight, activity, and health issues, requiring careful evaluation and more research for effective treatment.
September 2024 in “Medicine theory and practice” A young girl's hyperandrogenism was caused by an adrenocortical adenoma, diagnosed and treated through detailed evaluations.
1 citations
,
March 2025 in “Archivos Argentinos de Pediatria” Exposure to certain chemicals in food and containers may increase the risk of early breast development in young girls.
2 citations
,
July 2012 in “Journal of Pediatric and Adolescent Gynecology” A 12-year-old girl with very high testosterone and insulin resistance improved with birth control pills, suggesting PCOS can cause high testosterone without tumors.
December 1981 in “Pediatric Research” 26 citations
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January 1982 in “Hormone Research” Normal androgen levels need ACTH, and different mechanisms control adrenarche and gonadarche.
11 citations
,
October 2002 in “The Journal of Clinical Endocrinology & Metabolism” Enzyme activities do not cause early pubic hair in these girls.
February 2026 in “eYLS (Yale Law School)” Denying transgender minors gender-affirming care, while allowing it for cisgender minors, is sex discrimination.
13 citations
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January 2019 in “Endocrine journal” Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.
35 citations
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June 1997 in “Annals of the New York Academy of Sciences” Early diagnosis and multidisciplinary care are crucial for managing PCOS in adolescents.