245 citations
,
October 2015 in “Nature medicine” Hair follicle-derived IL-7 and IL-15 are crucial for maintaining skin-resident memory T cells and could be targeted for treating skin diseases and lymphoma.
134 citations
,
July 2020 in “Experimental dermatology” Hair follicles are normally protected from the immune system, but when this protection fails, it can cause hair loss in alopecia areata.
130 citations
,
April 2003 in “Journal of Investigative Dermatology” Four specific keratins in hair follicles help understand hair structure and function.
116 citations
,
August 2010 in “Nature” Scientists turned rat thymus cells into stem cells that can help repair skin and hair.
92 citations
,
December 2005 in “The Journal of clinical investigation/The journal of clinical investigation” Human hair follicle stem cells can be isolated using specific markers for potential therapeutic use.
83 citations
,
May 2013 in “International Journal of Molecular Sciences” Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.
81 citations
,
June 2014 in “Cold Spring Harbor perspectives in medicine” Skin has specialized touch receptors that can tell different sensations apart.
67 citations
,
July 2016 in “Reviews in Endocrine and Metabolic Disorders” Stress can worsen skin conditions by affecting hormone levels and immune response.
55 citations
,
January 2004 in “The International Journal of Developmental Biology” Corneal cells can transform into hair-producing skin cells when exposed to certain signals.
47 citations
,
November 2012 in “Pharmaceutical research” Surface-modified nanoparticles mainly use non-follicular pathways to enhance skin permeation of ibuprofen and could improve treatment for inflammatory skin diseases.
39 citations
,
November 2016 in “Pharmaceutics” The hair follicle pathway significantly affects how easily water-loving chemicals pass through the skin.
39 citations
,
April 1992 in “Development” Both cell and non-cell parts are important for rat whisker follicle regrowth.
37 citations
,
November 2003 in “Veterinary pathology” Hair loss in mice starts with immune cells damaging hair roots before it becomes visible.
33 citations
,
September 2007 in “Veterinary dermatology” Topical 0.1% tacrolimus significantly improved ear infections in cats.
28 citations
,
March 2011 in “Journal of Investigative Dermatology” Hair follicles help guide nerve growth, improving touch recovery in skin grafts.
27 citations
,
August 2021 in “Journal of Autoimmunity” Human dermal γδT-cells respond to stress in hair follicles, contributing to hair loss.
27 citations
,
September 2012 in “Dermatologic Clinics” The document concludes that using specific tools and tests is essential for identifying the cause of hair loss and deciding on the right treatment.
25 citations
,
April 2021 in “npj Regenerative Medicine” Mathematical modeling can improve regenerative medicine by predicting biological processes and optimizing therapy development.
20 citations
,
April 2011 in “Dermatologic Surgery” Laser therapy helped new hair grow in scarred skin for three patients.
19 citations
,
April 2016 in “Experimental Dermatology” Melanoblasts migrate to the skin using various pathways, and understanding this process could help with skin disease research.
19 citations
,
January 2007 in “Journal of medical investigation” GFP transgenic mice help study cell origins in skin grafts.
16 citations
,
August 2019 in “Cell Proliferation” Keratinocytes help keep hair follicle cells and skin cells separate in 3D cultures, which is important for hair growth research.
15 citations
,
December 2011 in “Journal of the European Academy of Dermatology and Venereology” Hair loss in systemic lupus erythematosus patients is unique and improves with treatment.
13 citations
,
June 2016 in “Dermatologic Therapy” Minoxidil works better when applied on a damp scalp than a dry one.
12 citations
,
November 1945 in “Archives of dermatology” Transplanted skin on hooded rats often grows white hair instead of black.
11 citations
,
September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” A specific group of skin stem cells was found to help maintain hair follicle cells.
10 citations
,
June 2018 in “Journal of visualized experiments” The document concludes that the technique allows for the detection of LDH activity in various tissues, showing where cells are actively metabolizing glucose.
9 citations
,
November 2021 in “Frontiers in Cell and Developmental Biology” PBX1 helps reduce aging and cell death in hair follicle stem cells by decreasing DNA damage, not by improving DNA repair.
9 citations
,
May 2021 in “Immunological Reviews” Different types of fibroblasts play various roles in kidney repair and aging, and may affect chronic kidney disease outcomes.
9 citations
,
June 2000 in “Journal of The American Academy of Dermatology” Mutation in hairless gene may increase hair loss risk.