November 1999 in “Journal of Cutaneous Medicine and Surgery” Treatments for hair loss include hormone modifiers, minoxidil, and hair transplant surgery.
94 citations
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August 2002 in “Experimental Dermatology” 17α-estradiol boosts aromatase activity in female hair follicles, potentially helping with hair loss.
87 citations
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April 1973 in “Endocrinology” The chemicals 17βC and its methyl ester can block the effects of testosterone on hamster skin but not the effects of DHT.
54 citations
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July 2002 in “Clinical and Experimental Dermatology” DHT, a testosterone byproduct, causes male pattern baldness.
50 citations
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March 2001 in “Clinics in Dermatology” Genes and hormones cause hair loss, with four genes contributing equally.
39 citations
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August 2004 in “International journal of gynaecology and obstetrics” Finasteride and CPA-EE2 equally reduce hirsutism, but affect hormone levels differently.
39 citations
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November 1978 in “Annals of internal medicine” Spironolactone may help reduce excessive hair growth in women with high male hormone levels.
33 citations
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August 2018 in “Facial Plastic Surgery Clinics of North America” The document explains hair biology, the causes of hair loss, and reviews various hair loss treatments.
32 citations
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December 2017 in “Journal of Drug Delivery Science and Technology” Minoxidil and caffeine in transfersomes improve hair growth treatment.
31 citations
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October 1971 in “Steroids” Human beard hair follicles change testosterone into other related hormones, but don't much change androstenedione into testosterone.
29 citations
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December 1998 in “Seminars in Cutaneous Medicine and Surgery” New treatments for hair loss show promise, especially finasteride for men and a stronger minoxidil formula.
29 citations
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January 1998 in “Dermatology” Many acne patients have high androgen levels, which may lead to PCOD, but treatments like oral contraceptives and antiandrogens can help.
28 citations
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June 2000 in “PubMed” Androgenetic alopecia is common hair loss due to genetics and DHT.
24 citations
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March 2003 in “Best Practice & Research Clinical Endocrinology & Metabolism” Androgens, male hormones, play a role in both men and women's health, and testosterone therapy can help women with low levels, but it's not suitable for pregnant or lactating women, or those with certain conditions.
23 citations
,
May 1984 in “Journal of the American Geriatrics Society” Benign Prostatic Hyperplasia may be caused by changes in how the body processes male hormones.
22 citations
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October 2019 in “Cerebral cortex” Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.
19 citations
,
May 2013 in “Annals of Oncology” Aromatase inhibitors cause male pattern hair loss in women.
19 citations
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June 1999 in “Steroids” Different halogens on progesterone derivatives can either block or mimic male hormone effects, depending on their type and amount.
19 citations
,
March 1998 in “Endocrinology” Male rats have more somatostatin neurons than females due to testosterone converting to estrogen during early development.
16 citations
,
August 1989 in “Human Reproduction” Hirsutism in females is caused by high male hormones or sensitive hair follicles.
15 citations
,
January 2017 in “Advances in Experimental Medicine and Biology” 5α-Reductase inhibitors can negatively affect male sexual function and, in some cases, significantly reduce sperm count, but these effects may be reversible.
14 citations
,
February 1998 in “Bioorganic & Medicinal Chemistry Letters” Some newly made compounds can block an enzyme linked to hair loss and prostate growth, with one in particular being very selective.
12 citations
,
March 2004 in “Der Urologe” There is no strong evidence that chemopreventive agents effectively prevent prostate cancer.
11 citations
,
September 2020 in “OncoTargets and Therapy” Dihydrotestosterone increases growth and spread of human brain cancer cells, and blocking its formation might help treat this cancer.
10 citations
,
March 2019 in “Journal of neuroendocrinology” Testosterone affects stress hormone levels differently in adolescent and adult male rats.
7 citations
,
December 2022 in “Plants” Guava leaf extract may help treat hair loss and protect cells by blocking certain genes and fighting damaging molecules.
5 citations
,
September 2011 in “Andrologia” Finasteride use may be linked to rare testicular tumor, but more research needed.
3 citations
,
June 2017 in “Reproductive biomedicine online” A certain mutation in the fetal alpha 5-reductase gene is linked to a higher risk of late miscarriage.
3 citations
,
April 2015 in “American journal of biomedical sciences” Androgens play a key role in hair growth and disorders like baldness and excessive hairiness.
2 citations
,
July 2018 in “Journal of Cosmetic Dermatology” Common latent viruses might contribute to male-pattern baldness by disrupting cell processes that normally suppress hair loss-related proteins.