38 citations
,
June 2018 in “Archives of Toxicology” Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.
36 citations
,
May 2017 in “The journal of sexual medicine” Cyproterone acetate treatment is safe and causes mild feminization, which increases with added estrogen.
36 citations
,
November 1995 in “Clinical endocrinology” Low-dose flutamide helps reduce excessive hair growth and is even more effective with birth control, without bad effects on blood fats.
35 citations
,
May 2022 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism” Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.
33 citations
,
December 2023 in “Cell Death Discovery” Cepharanthine may help treat gastric cancer by causing cancer cell death and affecting energy use.
33 citations
,
October 1994 in “The Journal of Clinical Endocrinology and Metabolism” Finasteride reduces hair growth and is safe for women with excessive hair.
30 citations
,
March 2015 in “Clinical Endocrinology” Young women with high male hormone levels or PCOS often feel more psychological distress and have a lower quality of life.
30 citations
,
January 2000 in “Dermatologic Clinics” Finasteride and minoxidil are effective FDA-approved treatments for androgenetic alopecia.
25 citations
,
September 2015 in “Clinical Endocrinology” Using 17-hydroxyprogesterone levels to diagnose nonclassic congenital adrenal hyperplasia can result in many incorrect diagnoses.
24 citations
,
May 2015 in “Schizophrenia Research” A drug improved schizophrenia-like symptoms in stressed rats by changing brain steroid levels.
24 citations
,
September 2005 in “Journal of Cellular Biochemistry” Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.
24 citations
,
March 2001 in “Journal of Endocrinology/Journal of endocrinology” Red deer only have androgen receptors in neck hair cells for mane growth during breeding season.
23 citations
,
February 2021 in “Journal of Endocrinological Investigation” Betacoronaviruses, like COVID-19, may cause hormone system dysfunction and affect disease susceptibility and severity.
23 citations
,
April 1999 in “The Journal of Clinical Endocrinology and Metabolism” All treatments reduce hair growth; low dose flutamide most effective with fewer side effects.
23 citations
,
July 1993 in “Pharmacotherapy” Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.
22 citations
,
November 2011 in “Journal of Analytical Toxicology” Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.
22 citations
,
March 2000 in “Clinics in Dermatology” Many treatments for hair loss lack proper testing and FDA approval, so their effectiveness is uncertain.
21 citations
,
October 2011 in “PloS one” Certain molecules in hair change with age and could be used for cosmetic treatments.
20 citations
,
November 2019 in “Biomolecules” Finasteride reduces response to stress and rewards, affecting behavior and mental health.
19 citations
,
December 2019 in “Steroids” Finasteride and dutasteride reduce neurosteroid production, possibly helping treat glioblastoma.
19 citations
,
May 1984 in “Digestive diseases and sciences” A young woman's Cronkhite-Canada syndrome improved on its own after she gave birth.
18 citations
,
September 2023 in “Nutrition Research Reviews” Higher fiber intake may reduce psoriasis severity, but more research is needed for effective dietary strategies.
18 citations
,
February 2016 in “The Journal of Clinical Endocrinology and Metabolism” Advancements in male reproductive medicine are ongoing, but more research and improved treatments are needed in several areas.
18 citations
,
March 2009 in “Medical Hypotheses” The document suggests that blocking sweat glands with antiperspirants might allow skin-generated hormones to be absorbed, possibly increasing breast and prostate cancer risk.
18 citations
,
January 2004 in “Dermatologic Clinics” Skin problems in older people can indicate hormonal diseases, nutritional deficiencies, or conditions like diabetes, menopause, and HIV.
17 citations
,
May 2021 in “Journal of Assisted Reproduction and Genetics” COVID-19 may harm male fertility and damage the reproductive system.
17 citations
,
October 2017 in “Scientific reports” Fine wool sheep have more genes for wool quality, while coarse wool sheep have more for skin and muscle traits.
16 citations
,
January 2006 in “The Aging Male” Hormone imbalances can cause skin diseases, and understanding these links is important for diagnosis and treatment.
14 citations
,
December 2019 in “Iraqi Journal of Science” Iraqi women with PCOS often have higher testosterone levels and obesity.
14 citations
,
February 2018 in “Psychoneuroendocrinology” Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.