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research Generation of a Novel Inducible and Dermal Papilla‐Specific Wif1‐CreER Knock‐In Mouse Line for Hair Follicle Research

May 2025 in “Experimental Dermatology”

A new genetic tool improves the study of hair growth and potential hair disorder treatments.

research An essential role for Rxrα in the development of Th2 responses

50 citations , December 2005 in “European Journal of Immunology”

RXRα is crucial for proper immune response and links diet to immune function.

research The alopecia areata phenotype is induced by the water avoidance stress test in cchcr1-deficient mice

December 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Stress can cause a type of hair loss in mice lacking the CCHCR1 gene.

research The parathyroid hormone-related protein as a regulator of normal tissue functions

4 citations , January 1994 in “Current Opinion in Endocrinology & Diabetes”

PTHrP regulates various normal body functions, including bone development, skin, and muscle function.

research RhoA promotes epidermal stem cell proliferation via PKN1-cyclin D1 signaling

21 citations , February 2017 in “PLoS ONE”

RhoA helps skin stem cells grow, aiding wound healing.

research Conditional Activin Receptor Type 1B (Acvr1b) Knockout Mice Reveal Hair Loss Abnormality

46 citations , December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

Disrupting Acvr1b in mice causes severe hair loss and thicker skin.

Circadian Rhythm Sleep-Wake Disorders: Linking Circadian Misalignment to Adverse Health Outcomes

research Circadian rhythm sleep-wake disorders (CRSWDs): Linking circadian misalignment to adverse health outcomes.

5 citations , November 2020 in “EBioMedicine”

Disruptions in sleep-wake cycles can cause health problems like mental, metabolic, and heart diseases, and cancer.

research Human Hairless Protein Roles in Skin/Hair and Emerging Connections to Brain and Other Cancers

15 citations , May 2017 in “Journal of Cellular Biochemistry”

The hairless protein is important for skin, hair, and may influence cancer development.

research Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice.

114 citations , July 2003 in “PubMed”

Lack of KSR1 stops certain skin tumors in mice.

Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

research Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

6 citations , September 2015 in “Journal of Medicinal Chemistry”

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

research CBL1‐CIPK26‐mediated phosphorylation enhances activity of the NADPH oxidase RBOHC, but is dispensable for root hair growth

32 citations , July 2018 in “FEBS letters”

A specific protein complex increases the activity of a plant enzyme, but this action is not required for plant root hair growth.

Efficient Genome Editing Using CRISPR/Cas9 Ribonucleoprotein Approach in iPS Cells for Recessive Dystrophic Epidermolysis Bullosa

research 924 Efficient genome editing using CRISPR/Cas9 ribonucleoprotein approach in iPS cells for recessive dystrophic epidermolysis bullosa

April 2019 in “Journal of Investigative Dermatology”

Researchers fixed gene mutations causing a skin disease in stem cells, which then improved skin grafts in mice.

research Is thyrotropin-releasing hormone a novel neuroendocrine modulator of keratin expression in human skin?

10 citations , February 2013 in “British Journal of Dermatology”

Thyrotropin-releasing hormone may help control skin and hair growth and could aid in treating related disorders.

Thyrotropin-Releasing Hormone Promotes Wound Re-Epithelialisation in Frog and Human Skin

research Thyrotropin-Releasing Hormone (TRH) Promotes Wound Re-Epithelialisation in Frog and Human Skin

46 citations , September 2013 in “PLOS ONE”

Thyrotropin-Releasing Hormone helps heal wounds in frog and human skin.

research Expression, characterization, and structural analysis of human liver delta4-3-ketosteroid 5beta-reductase (AKR1D1) and its disease-related mutant P133R

January 2009 in “ScholarlyCommons (University of Pennsylvania)”

The P133R mutation in AKR1D1 enzyme causes harmful bile acid buildup, explaining related health issues.

research Case report: Heterozygous mutation in HTRA1 causing typical cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy

1 citations , September 2023 in “Frontiers in Genetics”

A heterozygous mutation in HTRA1 can cause severe CARASIL symptoms.

research Defective control of growth rate and cell diameter in tip-growing root hairs of therhd4mutant ofArabidopsis thaliana

26 citations , September 1999 in “Canadian Journal of Botany”

The RHD4 gene is crucial for consistent root hair growth in Arabidopsis thaliana.

research Atrichia with papular lesions resulting from a novel insertion mutation in the human hairless gene

19 citations , May 2006 in “Clinical and Experimental Dermatology”

Researchers found a new mutation causing total hair loss from birth.

research 688 Precise and efficient editing of the COL7A1 gene in RDEB derived iPSCs with CRISPR/Cas9 and prime editing

July 2024 in “Journal of Investigative Dermatology”

CRISPR/Cas9 and prime editing can potentially fix skin disorder genes safely and effectively.

research Expression of retinoid-X receptors (-Æ,-a,-a) and retinoic acid receptors (-Æ,-a,-a) in normal human skin: an immunohistological evaluation

January 1997

RXR and RAR proteins in skin may help with cell growth, hair growth, and gland function.

research 126 cAMP response element-binding protein 1 (CREB) is a β-catenin-regulated transcription factor in squamous cell carcinoma (SCC) cells

April 2018 in “Journal of Investigative Dermatology”

CREB, a protein that can promote cancer traits, is controlled by β-catenin in skin cancer cells.

research Sequence-structure based phylogeny of GPCR Class A Rhodopsin receptors

57 citations , May 2014 in “Molecular Phylogenetics and Evolution”

The research found how GPCR Class A Rhodopsin receptors are related and suggested possible substances they interact with.

research Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation.

478 citations , September 1996 in “Proceedings of the National Academy of Sciences”

Overexpression of PTHrP in chondrocytes causes short-limbed dwarfism and delayed bone formation in mice.

research 078 The transmembrane protein LRIG1 regulates receptor tyrosine kinases in skin development and homeostasis

September 2017 in “Journal of Investigative Dermatology”

LRIG1 protein affects hair growth by regulating skin receptors, leading to hair loss when overexpressed.

research Expression of melanocortin receptors on cutaneous fibroblastic cells – collagen and beyond

1 citations , January 2005 in “Experimental Dermatology”

MC-1R in skin cells may influence inflammation and collagen production.

research Identification of the Rat Rex Mutation as a 7-bp Deletion at Splicing Acceptor Site of the Krt71 Gene

45 citations , January 2010 in “Journal of Veterinary Medical Science”

A gene mutation causes curly hair and hair loss in rats.

Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets (HVDRR): Clinical Heterogeneity and Long-Term Efficacious Management of Eight Patients from Four Unrelated Arab Families with a Loss of Function VDR Mutation

research Hereditary 1,25-dihydroxyvitamin D-resistant rickets (HVDRR): clinical heterogeneity and long-term efficacious management of eight patients from four unrelated Arab families with a loss of function VDR mutation

6 citations , June 2018 in “Journal of pediatric endocrinology & metabolism/Journal of pediatric endocrinology and metabolism”

Patients with the same genetic mutation for vitamin D-resistant rickets showed different symptoms but all improved with treatment except for hair loss.

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