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research Increased CRHR1 expression on monocytes from patients with AA enables a pro‐inflammatory response to corticotrophin‐releasing hormone

3 citations , October 2024 in “Experimental Dermatology”

Higher CRHR1 levels in AA patients lead to increased inflammation.

research 63418 JAK3/TEC kinase pathways are active in alopecia areata lesions, and their inhibition with Ritlecitinib prevents αCD3/αCD28+IL-2 induced immune privilege collapse in healthy hair follicles ex vivo

September 2025 in “Journal of the American Academy of Dermatology”

Ritlecitinib may help treat alopecia areata by protecting hair follicles.

research Identification of drug-specific public TCR driving severe cutaneous adverse reactions

88 citations , August 2019 in “Nature communications”

Researchers found a specific immune receptor in patients that causes severe skin reactions to a drug.

research ECULIZUMAB IN THE MANAGEMENT OF CATASTROPHIC ANTIPHOSPHOLIPID SYNDROME WITH MULTIORGAN INVOLVEMENT: A CASE REPORT

May 2025 in “The Journal of Rheumatology”

Early diagnosis and treatment are crucial for CAPS, and Eculizumab can be effective.

research Anticytokine therapy, particularly anti-IFN-γ, in Th1-mediated autoimmune diseases

9 citations , May 2005 in “Expert Review of Clinical Immunology”

Blocking interferon-gamma might help treat various autoimmune diseases.

research CD271 orchestrates skin structure, differentiation, and inflammation via PI3K/Akt and PKCα/ERK pathways

October 2025 in “Cell Death and Disease”

CD271 is crucial for maintaining healthy skin and preventing inflammation.

research Cutaneous Lesions in the Rat Following Administration of an Irreversible Inhibitor of erbB Receptors, Including the Epidermal Growth Factor Receptor

21 citations , April 2008 in “Toxicologic Pathology”

CI-1033 causes skin lesions in rats, similar to humans, due to EGF receptor inhibition.

research LB789 Novel IFNγ aptamer TAGX-0003 protected hair follicles from immune privilege collapse and reversed Alopecia Areata like phenotype in humanized mouse model

August 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

TAGX-0003 protected hair follicles and reversed alopecia areata in a mouse model.

research Evaluation of immunoreactivity of normal tissues from dogs, using monoclonal antibody B72.3

August 1994 in “American Journal of Veterinary Research”

Monoclonal antibody B72.3 selectively reacts with certain dog tissues, mainly in the gastrointestinal and respiratory tracts.

research A Murine Monoclonal Antibody (VM-1) Against Human Basal Cells Inhibits the Growth of Human Keratinocytes in Culture

25 citations , April 1985 in “Journal of Investigative Dermatology”

research Resolution of Waldenström's macroglubulinemia related isolated neutropenia by immunochemotherapy

3 citations , January 2011 in “American Journal of Hematology”

Immunochemotherapy successfully treated neutropenia in a patient with Waldenström's macroglobulinemia.

research PROTACs: A novel strategy for cancer drug discovery and development

44 citations , May 2023 in “MedComm”

PROTAC technology shows promise for cancer treatment but needs more effective E3 ligase recruiters.

TCL1 Transgenic Mouse Model as a Tool for the Study of Therapeutic Targets and Microenvironment in Human B-Cell Chronic Lymphocytic Leukemia

research TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia

38 citations , January 2016 in “Cell Death and Disease”

The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.

research Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease

60 citations , September 2023 in “Science”

BTNL proteins help control inflammatory bowel disease by maintaining specific immune cells.

research The circular RNA circNlgnmediates doxorubicin-inducedcardiac remodeling and fibrosis

19 citations , March 2022 in “Molecular therapy. Nucleic acids”

A specific RNA, circNlgn, contributes to heart damage and scarring caused by the cancer drug doxorubicin.

research Phase II Evaluation of VDC‐1101 in Canine Cutaneous T‐Cell Lymphoma

28 citations , September 2014 in “Journal of Veterinary Internal Medicine”

VDC-1101 shows potential as a treatment for canine cutaneous T-cell lymphoma.

research 260 Anti-OX40 monoclonal antibody IMG-007 exhibited clinical activity of hair regrowth, suppressed scalp inflammatory biomarkers in patients with severe alopecia areata in a Ph1b/2a study

November 2025 in “Journal of Investigative Dermatology”

IMG-007 helps regrow hair and reduce scalp inflammation in severe alopecia areata.

research 15460 Perifollicular pink halo: A potential dermoscopic marker of inflammation in central centrifugal cicatricial alopecia

November 2020 in “Journal of The American Academy of Dermatology”

Certain immune markers may predict chemotherapy response in mesothelioma, and nivolumab is a tolerable and effective treatment for advanced non-small cell lung cancer.

research Anti-CD44-mediated blockade of leukocyte migration in skin-associated immune diseases

30 citations , April 2007 in “Journal of Leukocyte Biology”

Blocking CD44 can reduce leukocyte migration in autoimmune skin diseases.

research An essential role for Rxrα in the development of Th2 responses

50 citations , December 2005 in “European Journal of Immunology”

RXRα is crucial for proper immune response and links diet to immune function.

research Recombinant Thrombomodulin Used to Successfully Treat Cronkhite-Canada Syndrome with Disseminated Intravascular Coagulation due to Sepsis in a Compromised Patient

3 citations , June 2018 in “Internal Medicine”

Recombinant thrombomodulin can effectively treat severe complications in Cronkhite-Canada syndrome.

research Calcitonin gene‐related peptide (CGRP) may award relative protection from interferon‐γ‐induced collapse of human hair follicle immune privilege

47 citations , December 2011 in “Experimental Dermatology”

CGRP may help protect hair follicles from immune system attacks, potentially slowing hair loss.

research CFTR potentiator ivacaftor protects against noise-induced hair cell loss by increasing Nrf2 and reducing oxidative stress

4 citations , August 2023 in “Biomedicine & Pharmacotherapy”

Ivacaftor can protect against noise-induced hearing loss by reducing oxidative stress.

Halo Nevi, Vitiligo, and Diffuse Alopecia Areata Associated with Tocilizumab Therapy

research Halo naevi, vitiligo and diffuse alopecia areata associated with tocilizumab therapy

10 citations , August 2016 in “Oxford Medical Case Reports”

Tocilizumab therapy may cause skin and hair conditions like halo naevi, vitiligo, and alopecia areata.

research Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation

18 citations , January 2021 in “Theranostics”

The targeted nanohybrids effectively reduced psoriasis symptoms and improved skin health.

research Efficacy and safety of a novel anti‐HER2 therapeutic antibody RC48 in patients with HER2‐overexpressing, locally advanced or metastatic gastric or gastroesophageal junction cancer: a single‐arm phase II study

147 citations , October 2021 in “Cancer Communications”

RC48 shows promise for treating certain advanced cancers, but more research is needed.

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