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Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

Removing Gsdma1/2/3 genes reduces skin cell overgrowth by blocking a specific cell pathway.

A mouse model for studying scleroderma in chronic graft-versus-host disease was successfully created.

Deleting the MAD2L1 gene in mice led to rapid tumor growth despite chromosomal instability.

Drug approvals slowed in 2Q22, but notable drugs like Amvuttra, Camzyos, and Olumiant were approved.

Researchers made new compounds that could potentially be developed into anticancer drugs.

TICE salvage chemotherapy is effective for treating germ-cell tumors with poor prognosis.

Cinacalcet may help treat hereditary vitamin D resistant rickets safely.

Trametinib can effectively treat severe kaposiform lymphangiomatosis when other treatments fail.

TSC22D genes are key in metabolic diseases and cancer, offering potential as treatment targets.

Using Janus kinase inhibitors (JAKi) in COVID-19 treatment requires careful consideration due to their immunosuppressive effects.

A new compound slows cancer cell growth and causes cell death by blocking cell cycle progression and increasing cell-damaging molecules.

Combining MMP-9 and JAK inhibitors can effectively prevent skin depigmentation in vitiligo.

Vitamin D and glucocorticoids affect bone growth, metabolism, and immune response.

Certain genetic variants impair enzyme activity, contributing to non-classic congenital adrenal hyperplasia.

JAK inhibitors like tofacitinib are effective and safer for severe alopecia areata than glucocorticosteroids.

Aleglitazar and its major metabolite are safe enough to proceed to Phase 3 clinical trials.

The N-K GM Series offers highly selective, eco-friendly antimicrobials free for everyone.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

AtCSLD3 and GhCSLD3 genes enhance root growth and cell elongation in plants.

Intralesional triamcinolone acetonide can effectively limit the progression of GLPLS.

GI197111X is best dissolved in Capmul MCM for trials.

Lower GATA3 levels in mice help hair regrow by changing certain immune cells.

New drugs targeting DNA enzymes show promise for cancer treatment but have side effects like immune system suppression and hair loss.

Blocking the Wnt/β‐catenin pathway can speed up wound healing, reduce scarring, and improve cartilage repair.

Certain long non-coding RNAs in cashmere goats affect hair growth when treated with a specific growth factor.

Different types of skin gland tumors have unique genetic traits, which can guide personalized treatments.

Spironolactone, a heart and liver drug, has new uses including cancer treatment, viral infection prevention, and skin condition improvement.

Tofacitinib improved ulcerative colitis, skin ulcers, and hair loss in a patient who didn't respond well to other treatments.