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Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

research Growth factors and cytokines in hair follicle development and cycling: recent insights from animal models and the potentials for clinical therapy

100 citations , November 1996 in “Molecular Medicine Today”

Growth factors and cytokines are important for hair growth and could potentially treat hair loss, but more research is needed to overcome challenges before they can be used in treatments.

research Neuroendocrinology of the hair follicle: principles and clinical perspectives

98 citations , July 2014 in “Trends in Molecular Medicine”

Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.

Enhanced Ectodysplasin-A Receptor Signaling Alters Multiple Fiber Characteristics to Produce the East Asian Hair Form

research Enhanced ectodysplasin-A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair form

98 citations , June 2008 in “Human mutation”

A genetic change in the EDAR gene causes the unique hair traits found in East Asians.

research Human hair follicle: reservoir function and selective targeting

97 citations , September 2011 in “British Journal of Dermatology”

The human hair follicle can store topical compounds and be targeted for drug delivery with minimal side effects.

Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles

research Effects of EGF on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles

94 citations , February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

EGF makes hair follicles grow longer but stops hair production.

research Hair cycle-specific expression of versican in human hair follicles

88 citations , May 2005 in “Journal of Dermatological Science”

Versican, a protein, is less present in thinning hair follicles and this decrease might contribute to common hair loss in men.

research Spironolactone is an Effective and Well Tolerated Systemic Antiandrogen Therapy for Hirsute Women*

78 citations , May 1989 in “The Journal of Clinical Endocrinology & Metabolism”

Spironolactone effectively reduces hair growth in women with hirsutism and is generally well-tolerated.

research Stem cells and the circadian clock

75 citations , September 2017 in “Developmental biology”

The circadian clock influences the behavior and regeneration of stem cells in the body.

research Hair follicles’ transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog

75 citations , October 2016 in “Genes & Development”

Cells in hair follicles help create fat cells in the skin by releasing a protein called Sonic Hedgehog.

Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration

research Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration

72 citations , June 2001 in “Journal of Investigative Dermatology”

S100A4 and S100A6 proteins may activate stem cells for hair follicle regeneration and could be potential targets for hair loss treatments.

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