29 citations
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July 2015 in “Journal of Medical Genetics” A genetic variant in the KRT25 gene causes tightly curled hair.
30 citations
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March 2019 in “Archives animal breeding/Archiv für Tierzucht” The KRTAP15-1 gene affects cashmere fiber thickness in goats.
August 2001 in “The Journal of Cell Biology” A new keratin gene was found in mice, explaining hair growth.
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January 2019 in “Aging” Lack of functional CYLD in mice leads to early aging and cancer.
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February 2002 in “The Lancet” Keratinocytes might turn into stem cells, but more research is needed to confirm this.
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December 1991 in “Annals of the New York Academy of Sciences” Keratin gene regulation is similar across mammals, affecting hair follicle differentiation.
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April 2016 in “PloS one” The KRTAP11-1 gene promoter is crucial for specific expression in sheep wool cortex.
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December 2000 in “Experimental Dermatology” Involucrin is a useful marker for keratinocyte differentiation in mice.
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January 2019 in “Methods in molecular biology” A new method helps grow skin cells from humans and mice more easily and quickly.
42 citations
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January 2002 in “Skin Pharmacology and Physiology” Reconstructed skin models are useful for studying how skin processes certain chemicals.
January 2025 in “Cell Communication and Signaling” CXXC5 can both suppress and promote cancer, making it a complex target for treatment.
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October 2016 Understanding how keratin structures in hair are arranged and interact is key for creating methods to extract and purify them.
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June 2002 in “International Journal of Cosmetic Science” Advancements in hair keratin research could lead to better hair health treatments.
226 citations
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January 2006 in “International review of cytology” Keratin-associated proteins are crucial for hair strength and structure.
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September 2011 in “Stem Cell Reviews and Reports” January 2005 in “Journal of Shandong Univenity” Epidermal stem cells are in hair follicle bulge regions, and isolation and culture methods are effective.
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November 2018 in “Animal Genetics” A new gene variant causes curly coats in some dog breeds.
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January 2006 in “Cutaneous and ocular toxicology” L-cystine, D-pantothenat, and miliacin together significantly boost keratinocyte growth and metabolism.
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January 2015 in “China Animal Husbandry & Veterinary Medicine” Four keratin genes are crucial for hair growth in Xinji fine wool sheep.
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April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” The gene therapy showed significant wound healing and was safe for treating severe RDEB.
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August 2020 in “Current protocols in stem cell biology” Scientists developed a way to create skin and hair cells from human stem cells, which could help treat burns and restore hair.
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February 1991 in “Development” Fos protein is crucial for cell transition to cornification in keratinized tissues.
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February 2007 in “Journal of Investigative Dermatology” K39 and K40 are the last keratins expressed in hair development, completing the hair keratin catalog.
December 2025 in “American Journal of Dermatopathology” Keratin 19 may help diagnose and treat certain types of permanent hair loss.
62 citations
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August 2006 in “Journal of Chromatography B” Modern techniques have improved the understanding of keratin proteins, revealing their roles in various cells and potential in disease diagnosis.
80 citations
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June 2002 in “Molecular Biology of the Cell” Type II keratins are uniquely phosphorylated during stress and mitosis, affecting their structure and function.
119 citations
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September 2000 in “Journal of Biological Chemistry” GKLF/KLF4 and Sp1 control Keratin 19 gene activity, influencing cancer-related changes.