January 2021 in “Journal of clinical and cosmetic dermatology” Human skin responds to light with protective mechanisms, but more research is needed to understand these processes and their implications for health and therapy.
November 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Dermal EZH2 controls skin cell growth and differentiation in mice.
September 2019 in “Journal of Investigative Dermatology” Dermal Papilla Cells grown in 3D and with stem cells better mimic natural hair growth conditions than cells grown in 2D.
January 2018 in “Stem cell biology and regenerative medicine” The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.
Skin stem cells are crucial for maintaining and repairing skin, with potential for treating skin disorders and improving wound healing.
34 citations
,
April 2018 in “EMBO journal” The protein SLC1A3 is important for activating skin stem cells and is necessary for normal hair and skin growth in mice.
77 citations
,
April 2004 in “Gene expression patterns” The three estrogen receptor genes are highly expressed in zebrafish neuromasts during development.
1398 citations
,
May 2008 in “Histochemistry and Cell Biology” Keratins are crucial for cell stability, wound healing, and cancer diagnosis.
343 citations
,
December 2008 in “Endocrine Reviews” Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.
308 citations
,
September 2010 in “Nucleic acids research” Increasing mir-302 turns human hair cells into stem cells by changing gene regulation and demethylation.
128 citations
,
September 2011 in “British Journal of Dermatology” Obesity is linked to various skin problems and may increase the risk of skin cancer.
114 citations
,
February 2012 in “International Journal of Dermatology” Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.
100 citations
,
July 2018 in “Journal of The American Academy of Dermatology” People with alopecia areata often have other health issues like skin diseases, metabolic syndrome, stomach infections, lupus, anemia, thyroid problems, mental health issues, vitamin D deficiency, and hearing and eye problems.
84 citations
,
April 2013 in “Applied Microbiology and Biotechnology” Mannosylerythritol lipids are good for skin and hair care products.
60 citations
,
October 2014 in “Journal of the American Academy of Dermatology” Dermatologists play a key role in treating skin symptoms of PCOS like dark patches, excess hair, acne, and hair loss.
41 citations
,
August 2007 in “European Journal of Gastroenterology & Hepatology” A woman's total hair loss from hepatitis C treatment grew back after stopping the medication.
29 citations
,
December 2005 in “BioEssays” Wnt/ß-catenin signaling is crucial for regulating skin stem cells and hair growth, with the right levels and timing needed for proper function.
28 citations
,
January 2017 in “Critical Reviews in Therapeutic Drug Carrier Systems” Nanomaterials in biomedicine can improve treatments but may have risks like toxicity, needing more safety research.
26 citations
,
December 2020 in “Nature metabolism” Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.
24 citations
,
January 2019 in “Science China Life Sciences” Chitosan/LiCl composite scaffolds help heal deep skin wounds better.
21 citations
,
August 2011 in “Clinics in Dermatology” Looking at skin can help find and treat serious diseases early.
19 citations
,
March 2019 in “Behavioural Brain Research” Finasteride use can cause depression-like behavior in male rats.
17 citations
,
January 2022 in “Emerging infectious diseases” COVID-19 generally causes fewer complications than influenza, except for certain conditions like hair loss and heart issues.
17 citations
,
January 2014 in “Stem Cells Translational Medicine” Canine epidermal neural crest stem cells could be a promising treatment for spinal cord injuries in dogs.
13 citations
,
December 2001 in “Dermatologic therapy” Alopecia areata causes varying hair loss patterns, affecting hair, nails, and possibly glands, with treatment outcomes depending on disease duration and extent.
10 citations
,
March 2019 in “Human Genetics” A genetic mutation in the SGK3 gene causes hairlessness in Scottish Deerhounds and may relate to human hair loss.
10 citations
,
December 2015 in “Clinics in Dermatology” Diabetes can lead to blindness and skin problems, and managing blood sugar and blood pressure is crucial to prevent these complications.
9 citations
,
July 2020 in “Experimental Dermatology” Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.
7 citations
,
November 2000 in “Clinics in Dermatology” Most hair loss in children is caused by a few common conditions and is easy to diagnose, but rare types require careful evaluation.
2 citations
,
August 2025 in “Scientific Reports” Pexidartinib often causes liver issues and fatigue, especially in women.