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The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Anti-IL-12/IL-23 antibody therapy effectively treats psoriasiform skin lesions in IBD patients.

Niosomes improve minoxidil skin delivery for hair loss treatment.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

Zinc oxide nanoparticles in sunscreen do not penetrate deep into the skin.

Polymeric nanoparticles show promise for treating skin diseases.

Wnt signaling is crucial for skin development and health, and its disruption can cause skin diseases.

Niosomes are a promising, stable, and cost-effective drug delivery system with potential for improved targeting and safety.

Growing human skin cells in a 3D environment can stimulate new hair growth.

Spironolactone treatment increases the amount of testosterone available in the body.

Teriflunomide helps reduce multiple sclerosis symptoms and is safe for most patients.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Neurosteroids are crucial for stress response, and targeting specific receptors may help treat certain disorders.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

Contaminated water with heavy metals causes serious health issues like kidney and liver problems.

Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.

Ovarian and stress hormones can change GABA A receptors through neurosteroids.

Fat cells help recruit healing cells and build skin structure during wound healing.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

Wnt signaling helps heal injuries and could lead to new treatments.

Stem cells are crucial for skin repair and new treatments for chronic wounds.

Two main types of fibroblasts with unique functions and additional subtypes were identified in human skin.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

The Rotterdam Study aims to understand various diseases in older adults.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

About 7% to 15% of Iranian women have polycystic ovary syndrome, depending on the criteria used to diagnose it.

Tiny pollution particles called PM2.5 can harm skin cells by causing stress, damage to cell parts, and cell death.