33 citations
,
September 2017 in “Journal of clinical immunology” New treatments for immune disorders caused by FOXN1 deficiency are promising.
33 citations
,
September 2008 in “Dermatologic therapy” Doctors should know how to diagnose and treat PCOS, which often involves checking for high male hormone levels and using medications to manage symptoms.
32 citations
,
February 2017 in “Human Reproduction” Women with polycystic ovary syndrome tend to have a longer anogenital distance.
29 citations
,
March 2010 in “Journal of Endocrinological Investigation” Lipocalin-2 levels are higher in women with PCOS and may indicate insulin resistance.
29 citations
,
January 2009 in “Gynecological Endocrinology” Women with PCOS have higher levels of certain blood clotting factors, suggesting a greater risk of cardiovascular issues.
28 citations
,
February 2011 in “Clinical Endocrinology” Women with PCOS have unhealthy changes in their cholesterol particles that are not related to their body weight.
27 citations
,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” PCOS is a complex disorder managed by treating symptoms and requires a team of specialists.
26 citations
,
September 1969 in “The American journal of medicine” Cronkhite-Canada Syndrome often leads to death within 6-18 months.
25 citations
,
December 2017 in “The Journal of Clinical Endocrinology & Metabolism” Birth control pills combined with bicalutamide are more effective at reducing excessive hair growth in women with PCOS than birth control pills alone.
25 citations
,
September 2015 in “Clinical Endocrinology” Using 17-hydroxyprogesterone levels to diagnose nonclassic congenital adrenal hyperplasia can result in many incorrect diagnoses.
24 citations
,
February 2022 in “Reviews in Endocrine and Metabolic Disorders” Women with PCOS have a higher risk of severe COVID-19 due to related health issues.
24 citations
,
July 2019 in “Journal of Obstetrics and Gynaecology” The combination therapy improved PCOS symptoms in both obese and non-obese women, with weight loss in the obese group.
24 citations
,
November 2015 in “Annals of Nutrition and Metabolism” Certain SHBG gene variants, like rs727428, are linked to higher testosterone levels in women with PCOS.
24 citations
,
October 1995 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” The nafarelin test can reliably distinguish between gonadotropin deficiency and delayed puberty in teenage boys.
23 citations
,
December 2017 in “Scientific Reports” ARL15 is important for fat cell development and the release of the hormone adiponectin.
23 citations
,
February 1979 in “Veterinary Clinics of North America: Small Animal Practice” Treatment can improve survival and symptoms in dogs with Cushing's disease, but outcomes are unpredictable.
22 citations
,
January 2015 in “BioMed Research International” More adolescent girls in urban areas of India have Polycystic Ovary Syndrome compared to those in rural areas.
22 citations
,
February 2010 in “The Veterinary clinics of North America. Small animal practice/Veterinary clinics of North America. Small animal practice” The cause of atypical Cushing's syndrome in dogs, possibly linked to sex hormones, is not yet proven.
21 citations
,
February 2016 in “Reproductive Biomedicine Online” The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.
21 citations
,
October 2011 in “British Journal of Dermatology” Testosterone therapy helped 63% of androgen-deficient women grow scalp hair, but more research is needed.
21 citations
,
October 1980 in “Gastroenterology” The report described a unique case of Cronkhite-Canada syndrome with unusual polyps and an association with multiple myeloma.
20 citations
,
December 2000 in “Fertility and Sterility” The N363S gene variant does not cause higher adrenal androgen levels in women with polycystic ovary syndrome.
19 citations
,
August 2020 in “Gastroenterology report” There is no standard treatment for the rare Cronkhite–Canada syndrome, which can be fatal and lead to cancer.
19 citations
,
October 2018 in “Medicine” Oriental herbal medicine with moxibustion may improve pregnancy rates and other symptoms in PCOS, but more high-quality research is needed.
19 citations
,
July 2015 in “Journal of inherited metabolic disease” Methionine restriction works better than betaine for treating CBS deficiency symptoms in mice.
19 citations
,
July 2013 in “The obstetrician & gynaecologist” The document concludes that careful evaluation is needed to diagnose PCOS correctly due to similar symptoms in other conditions, and accurate testosterone level measurement is crucial.
18 citations
,
September 2018 in “Experimental physiology” Electro-acupuncture may help treat PCOS in rats by changing brain DNA methylation.
18 citations
,
April 2016 in “Endocrinology and Metabolism Clinics of North America” The document concludes that diagnosing PCOS in teenagers is difficult and should focus on specific hormone levels and menstrual irregularities, while also considering treatment for symptoms and related health issues.
18 citations
,
January 2015 in “Journal of obesity and weight loss therapy” Eating less starch and dairy helped overweight women with PCOS lose weight and improve symptoms.
18 citations
,
March 2014 in “Current Pharmaceutical Biotechnology” Metformin helps regulate menstrual cycles, induce ovulation, and improve pregnancy outcomes in women with PCOS.