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Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens

research Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens

12 citations , April 1995 in “Journal of Medicinal Chemistry”

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

Comparison of Safety and Efficacy of Topical Mometasone 0.1% Ointment, Calcipotriol 0.005% Ointment, and Tacrolimus 0.1% Ointment in Patients with Localized Alopecia Areata: A Triple-Arm Randomized Clinical Study

research Comparison of Safety and Efficacy of Topical Mometasone 0.1% Ointment, Calcipotriol 0.005% Ointment, and Tacrolimus 0.1% Ointment in Patients with Localized Alopecia Areata: A Triple-Arm Randomized Clinical Study

February 2025 in “Indian Dermatology Online Journal”

Calcipotriol is the safest and most effective for hair regrowth in localized alopecia areata.

A Case of Systemic Mastocytosis: An Ultrastructural and Immunohistochemical Study of Dermal Mast Cells in Relation to Activation of the Epidermal Melanin Unit

research A case of systemic mastocytosis - an ultrastructural and immunohistochemical study of the dermal mast cells in relation to activation of the epidermal melanin unit

2 citations , November 1998 in “Journal of The European Academy of Dermatology and Venereology”

Prednisone reduces organ mast cell infiltration but does not alter the abnormal appearance of mast cells in systemic mastocytosis.

research Spironolactone

January 2025

Spironolactone effectively treats hormonal acne, hair loss, and excess hair growth in women.

research Harm reduction measures in a recreational gym user with anabolic androgenic steroid dependence: a case report in the context of current best clinical practice

2 citations , August 2025 in “Harm Reduction Journal”

Non-medical steroid use in gym-goers is risky and needs better prevention and care strategies.

Topical Sodium Valproate-Loaded Nanospanlastics Versus Conventional Topical Steroid Therapy in Alopecia Areata: A Randomized Controlled Study

research Topical sodium valproate-loaded nanospanlastics versus conventional topical steroid therapy in alopecia areata: a randomized controlled study

January 2024 in “Archives of dermatological research”

Both treatments for alopecia areata showed similar modest effectiveness.

research Ovarian hyperthecosis coexisting with an incidental adrenal lesion: challenges in the diagnostic approach

May 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)”

Using GnRHa agonists helps diagnose and treat ovarian hyperthecosis when surgery isn't possible.

research Evaluation Of Oxidative Stress On Dogs With Demodicosis

August 2022 in “Turkish journal of veterinary research”

Demodicosis causes significant oxidative stress in dogs.

research In vitro [7-3H]-testosterone metabolism by the rat ventral prostate—Effect of some exogenous compounds

12 citations , February 1975 in “Journal of Steroid Biochemistry”

research [Anti-androgens. Their use in dermatology].

January 1981 in “PubMed”

Cyproterone acetate with ethynyl estradiol significantly improved acne and seborrhea in women, but was less effective for hair loss and excessive hair growth.

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