2 citations
,
July 2019 in “Digital Showcase Research, Scholarship, & Creative Works (University of Lynchburg)” No proven link between isotretinoin and depression.
February 2026 in “Postgraduate Medicine” 5-alpha reductase inhibitors slightly increase depression risk, but the risk varies based on the control group used.
August 2025 in “medRxiv (Cold Spring Harbor Laboratory)” 5-alpha reductase inhibitors may increase depression risk by 31%, but results vary based on comparison groups.
June 2025 in “Reactions Weekly” Finasteride may increase the risk of depression and suicidal thoughts.
7 citations
,
April 2021 in “Journal of Clinical Psychopharmacology” Finasteride may increase the risk of depression, anxiety, and suicidal thoughts.
4 citations
,
May 2019 in “The World Journal of Men's Health” Taking 5 alpha reductase inhibitor medication slightly increases the risk of depression, especially as you get older.
3 citations
,
January 2024 in “Revista da Associação Médica Brasileira” Women with PCOS are more likely to have depression and anxiety.
2 citations
,
September 2008 in “Fertility and Sterility” Women with PCOS and higher BMI, especially those with morbid obesity, are at greater risk for depression.
1 citations
,
June 2025 in “European Journal of Clinical Pharmacology” Finasteride may increase the risk of suicidality and depression, especially in younger people.
46 citations
,
June 2015 in “Fertility and Sterility” Insulin resistance is significantly linked to a higher risk of depression in women with PCOS.
March 2025 in “Journal of Cosmetic Dermatology” Finasteride use may increase depression and suicide risk, especially at 1 mg, so monitoring is advised.
Men with sexual side effects from finasteride may face higher risks of depression and suicidal thoughts.
2 citations
,
March 2020 in “Cns & Neurological Disorders-drug Targets” Lurasidone is effective for bipolar depression and schizophrenia, but more safety data is needed.
September 2025 in “Turkish Journal of Dermatology” Oxidative stress may play a role in alopecia areata, but depression and suicide risk are similar to healthy peers.
3 citations
,
August 2020 in “Urology Journal” Using 5-alpha reductase inhibitors may increase the risk of mild depression.
May 2017 in “Psychiatric news” BPH medications may increase the risk of self-harm and depression, especially in the first 18 months.
January 2026 in “Nutrients” Probiotics may help improve depression in women with PCOS.
August 2024 in “Australasian Journal of Dermatology” Finasteride users have a very low risk of mental health issues, but those with hair loss may have slightly higher anxiety and depression.
September 2025 in “Therapies” Finasteride use for hair loss may cause depression and suicidal thoughts, requiring careful monitoring.
101 citations
,
May 2014 in “PLOS ONE” Women with PCOS have a higher chance of experiencing depression, anxiety, and sleep disorders.
202 citations
,
January 2022 in “Journal of Clinical Medicine” Women are more likely to have long-term post-COVID symptoms than men.
February 2021 in “The Brown University Psychopharmacology Update” Finasteride use in young people may increase risk of suicidal thoughts and mental health issues.
February 2012 in “Community oncology” Finasteride for hair loss may increase the risk of certain cancers and has side effects; better regulation and education on its use are needed.
2 citations
,
August 2016 in “Experimental Dermatology” Finasteride treats baldness but may cause lasting sexual side effects.
1 citations
,
January 2020 in “Skin appendage disorders” Finasteride is safe for hair loss treatment and doesn't increase high-grade prostate cancer risk.
66 citations
,
June 2013 in “Journal of Dermatological Treatment” Finasteride and dutasteride effectively treat hair loss, but may cause side effects like sexual dysfunction and depression.
52 citations
,
March 2016 in “JAMA dermatology” Patients with PCOS rate their hirsutism higher than clinicians, and these self-ratings are more closely related to their quality of life and risk of depression.
February 2025 in “Clinical Cosmetic and Investigational Dermatology” Genetic risk for hair loss can increase depression risk, but depression doesn't increase hair loss risk.
1265 citations
,
October 2013 in “The Journal of Clinical Endocrinology and Metabolism” The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.
December 2025 in “International Journal of Research in Dermatology” Isotretinoin effectively treats severe acne but has serious side effects and requires careful monitoring.