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GlossaryDermal Sheath Cup Cells

specialized cells supporting hair follicle growth and regeneration

Dermal Sheath Cup Cells are specialized cells located at the base of hair follicles. They play a crucial role in hair growth and regeneration by providing structural support and signaling to the surrounding follicular cells, which helps in the cycling and maintenance of hair.

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Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss Using Dermal Sheath Cup Cells: A Randomized Placebo-Controlled Double-Blinded Dose-Finding Clinical Study

research Autologous cell–based therapy for male and female pattern hair loss using dermal sheath cup cells: A randomized placebo-controlled double-blinded dose-finding clinical study

22 citations , March 2020 in “Journal of The American Academy of Dermatology”

DSC cell injections significantly improved hair density and diameter, showing potential as a hair loss treatment.

Combating Aging in Dermal Papilla Cells and Promoting Hair Follicle Regeneration Using Exosomes from Human Hair Follicle Dermal Sheath Cup Cells

research Combatting ageing in dermal papilla cells and promoting hair follicle regeneration using exosomes from human hair follicle dermal sheath cup cells

November 2023 in “Experimental Dermatology”

Exosomes from human hair follicle cells can improve aging hair follicle cell function and help regenerate hair follicles.

High Migratory Activity of Dermal Sheath Cup Cells and Clinical Efficacy in Autologous Therapy for Hair Loss

research High migratory activity of dermal sheath cup cells associated with the clinical efficacy of autologous cell-based therapy for pattern hair loss

November 2023 in “Journal of Dermatological Science”

Cells that move well may improve hair loss treatments by entering hair follicles.

Efficacy of Autologous Dermal Sheath Cup Cell Transplantation in Male and Female Pattern Hair Loss: A Single-Arm, Multi-Center, Phase III Equivalent Clinical Study

research Efficacy of autologous dermal sheath cup cell transplantation in male and female pattern hair loss: A Single‐Arm, Multi‐Center, phase III equivalent clinical study

September 2023 in “The Journal of Dermatology”

Transplanting one's own hair follicle cells can improve hair loss in men and women, and is particularly effective in women.

research 602 Efficacy of autologous cell-based therapy for male and female pattern hair loss using dermal sheath cup cells: A single arm, multi-center, confirmatory clinical study

April 2023 in “Journal of Investigative Dermatology”

Autologous cell-based therapy using dermal sheath cup cells may help treat pattern hair loss, especially in women.

research Changes in the Expression of Smooth Muscle Cell–Related Genes in Human Dermal Sheath Cup Cells Associated with the Treatment Outcome of Autologous Cell–Based Therapy for Male and Female Pattern Hair Loss

2 citations , June 2022 in “International Journal of Molecular Sciences”

Lower levels of certain genes in hair cells improve hair loss treatment outcomes.

Morphometric Prediction of Mesenchymal Stromal Cell-Like Immunosuppressive Capacity of Human Hair Follicle Dermal Sheath Cup Cells: An Implication for Regenerative Medicine in Hair Loss Diseases

research Morphometric prediction of mesenchymal stromal cell-like immunosuppressive capacity of human hair follicle dermal sheath cup cells: an implication for regenerative medicine in hair loss diseases

November 2025 in “Stem Cell Research & Therapy”

Human hair follicle cells can help regenerate hair and reduce inflammation, aiding in hair loss treatment.

Phase I/IIa Clinical Trial for the Treatment of Androgenetic Alopecia Using Intradermal Injections of Cultured Autologous Dermal Sheath Cup Cells

research 281 Phase I/IIa clinical trial for the treatment of androgenetic alopecia using intradermal injections of cultured autologous dermal sheath cup cells

September 2017 in “Journal of Investigative Dermatology”

Injections of special skin cells showed potential in treating hair loss, with some participants experiencing increased hair density.

research Correction to “Efficacy of Autologous Dermal Sheath Cup Cell Transplantation in Male and Female Pattern Hair Loss: A Single‐Arm, Multi‐Center, Phase III Equivalent Clinical Study”

January 2026 in “The Journal of Dermatology”

research ISID0602 – Efficacy of autologous cell-based therapy for male and female pattern hair loss using dermal sheath cup cells: A single arm, multi-center, confirmatory clinical study.

May 2023

research Differential Expression of CXCL12 in Human and Mouse Hair: Androgens Induce CXCL12 in Human Dermal Papilla and Dermal Sheath Cup

December 2024 in “International Journal of Molecular Sciences”

Targeting CXCL12 may help treat hair loss caused by androgens.

research Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege

53 citations , September 2013 in “Journal of Investigative Dermatology”

Hair follicle cells help protect against immune attacks by regulating T-cell activity.

research Wnt activator CHIR99021-stimulated human dermal papilla spheroids contribute to hair follicle formation and production of reconstituted follicle-enriched human skin

40 citations , June 2019 in “Biochemical and Biophysical Research Communications”

CHIR99021 helps create human skin with hair follicles, offering hope for hair loss treatments.

research Cell-based treatments for hair loss: research update on “hair cloning”

2 citations , March 2013 in “Hair transplant forum international”

Research on "hair cloning" for hair loss shows potential for hair thickening but has not yet achieved new hair growth in humans.

research Cell Movement in the Hair Follicle Dermis – More Than a Two-Way Street?

47 citations , December 2003 in “Journal of Investigative Dermatology”

DS cells in hair follicles can help form and restore hair, especially in hair loss conditions.

research Alteration of Skin Properties with Autologous Dermal Fibroblasts

67 citations , May 2014 in “International Journal of Molecular Sciences”

Using your own skin cells can help repair aging skin and promote hair growth.

research Hair Physiology (Hair Growth, Alopecia, Scalp Treatment, etc.)

1 citations , January 2017 in “Elsevier eBooks”

The document concludes that new treatments for hair loss may involve a combination of cosmetics, clinical methods, and genetic approaches.

research 282 WITHDRAWN

September 2017 in “Journal of Investigative Dermatology”

HIF-1A may aid hair growth, Backhousia citriodora improves skin, autologous cells stabilize hair loss, infrared thermography assesses alopecia, and a new treatment preserves hair.

research Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles

11 citations , January 2018 in “Acta dermato-venereologica”

Researchers found specific genes in the part of hair follicles that could help treat hair disorders.

research Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type

184 citations , November 2014 in “Developmental Cell”

Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.

research Single-Cell RNA Profiling of Human Skin Reveals Age-Related Loss of Dermal Sheath Cells and Their Contribution to a Juvenile Phenotype

37 citations , January 2022 in “Frontiers in Genetics”

Aging reduces dermal sheath cells, affecting youthful skin appearance.

research Hair matrix germinative epidermal cells confer follicle-inducing capabilities on dermal sheath and high passage papilla cells

61 citations , October 1996 in “Development”

Hair growth can be stimulated by combining certain skin cells, which can rejuvenate old cells and cause them to specialize in hair follicle creation.

research Dermal Sheath Cells and Hair Follicle Regeneration

January 2022 in “Stem cell biology and regenerative medicine”

Dermal sheath cells can help grow new hair follicles and show promise in treating hair loss.

research Single-Cell Proteomics Uncovers Dual Traits of Dermal Sheath Cells in Wound Repair

1 citations , January 2025 in “Advances in Wound Care”

Dermal sheath cells help heal wounds by showing both skin and connective tissue traits.

research Exploring the Role of Dermal Sheath Cells in Wound Healing and Fibrosis

1 citations , June 2024 in “Preprints.org”

Dermal sheath cells play a key role in wound healing and could impact fibrosis.

research Understanding the functional contribution of dermal stem cells to hair follicle regeneration and skin wound healing

January 2017

Dermal stem cells help regenerate hair follicles and heal skin wounds.

MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

research miR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

18 citations , December 2020 in “Frontiers in cell and developmental biology”

miR-140-5p in certain cell vesicles helps hair growth by boosting cell proliferation.

research Human Hair Follicle-Derived Mesenchymal Stromal Cells from the Lower Dermal Sheath as a Competitive Alternative for Immunomodulation

7 citations , January 2022 in “Biomedicines”

Cells from the lower part of hair follicles are a promising, less invasive option for immune system therapies.

research 022 Randomized, double-blind, placebo-controlled, single-centre, phase I safety study of intradermal injections of autologous fibroblasts isolated from the non-bulbar dermal sheath of the hair follicle to treat skin aging

September 2017 in “Journal of Investigative Dermatology”

RCS-01 is safe and may help rejuvenate aging skin.

research Anagen hair follicle repair: Timely regenerative attempts from plastic extra‐bulge epithelial cells

18 citations , January 2019 in “Experimental Dermatology”

Certain cells outside the hair follicle's bulge area can quickly regenerate damaged hair follicles, potentially helping to reduce hair loss from cancer treatments.