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GlossaryDermal Sheath Cup Cells

specialized cells supporting hair follicle growth and regeneration

Dermal Sheath Cup Cells are specialized cells located at the base of hair follicles. They play a crucial role in hair growth and regeneration by providing structural support and signaling to the surrounding follicular cells, which helps in the cycling and maintenance of hair.

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Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss Using Dermal Sheath Cup Cells: A Randomized Placebo-Controlled Double-Blinded Dose-Finding Clinical Study

research Autologous cell–based therapy for male and female pattern hair loss using dermal sheath cup cells: A randomized placebo-controlled double-blinded dose-finding clinical study

22 citations , March 2020 in “Journal of The American Academy of Dermatology”

DSC cell injections significantly improved hair density and diameter, showing potential as a hair loss treatment.

research Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles

11 citations , January 2018 in “Acta dermato-venereologica”

Researchers found specific genes in the part of hair follicles that could help treat hair disorders.

research Differential Expression of CXCL12 in Human and Mouse Hair: Androgens Induce CXCL12 in Human Dermal Papilla and Dermal Sheath Cup

December 2024 in “International Journal of Molecular Sciences”

Targeting CXCL12 may help treat hair loss caused by androgens.

Combating Aging in Dermal Papilla Cells and Promoting Hair Follicle Regeneration Using Exosomes from Human Hair Follicle Dermal Sheath Cup Cells

research Combatting ageing in dermal papilla cells and promoting hair follicle regeneration using exosomes from human hair follicle dermal sheath cup cells

November 2023 in “Experimental Dermatology”

Exosomes from human hair follicle cells can improve aging hair follicle cell function and help regenerate hair follicles.

High Migratory Activity of Dermal Sheath Cup Cells and Clinical Efficacy in Autologous Therapy for Hair Loss

research High migratory activity of dermal sheath cup cells associated with the clinical efficacy of autologous cell-based therapy for pattern hair loss

November 2023 in “Journal of Dermatological Science”

Cells that move well may improve hair loss treatments by entering hair follicles.

Efficacy of Autologous Dermal Sheath Cup Cell Transplantation in Male and Female Pattern Hair Loss: A Single-Arm, Multi-Center, Phase III Equivalent Clinical Study

research Efficacy of autologous dermal sheath cup cell transplantation in male and female pattern hair loss: A Single‐Arm, Multi‐Center, phase III equivalent clinical study

September 2023 in “The Journal of Dermatology”

Transplanting one's own hair follicle cells can improve hair loss in men and women, and is particularly effective in women.

research Changes in the Expression of Smooth Muscle Cell–Related Genes in Human Dermal Sheath Cup Cells Associated with the Treatment Outcome of Autologous Cell–Based Therapy for Male and Female Pattern Hair Loss

2 citations , June 2022 in “International Journal of Molecular Sciences”

Lower levels of certain genes in hair cells improve hair loss treatment outcomes.

Morphometric Prediction of Mesenchymal Stromal Cell-Like Immunosuppressive Capacity of Human Hair Follicle Dermal Sheath Cup Cells: An Implication for Regenerative Medicine in Hair Loss Diseases

research Morphometric prediction of mesenchymal stromal cell-like immunosuppressive capacity of human hair follicle dermal sheath cup cells: an implication for regenerative medicine in hair loss diseases

November 2025 in “Stem Cell Research & Therapy”

Human hair follicle cells can help regenerate hair and reduce inflammation, aiding in hair loss treatment.

Phase I/IIa Clinical Trial for the Treatment of Androgenetic Alopecia Using Intradermal Injections of Cultured Autologous Dermal Sheath Cup Cells

research 281 Phase I/IIa clinical trial for the treatment of androgenetic alopecia using intradermal injections of cultured autologous dermal sheath cup cells

September 2017 in “Journal of Investigative Dermatology”

Injections of special skin cells showed potential in treating hair loss, with some participants experiencing increased hair density.

research Correction to “Efficacy of Autologous Dermal Sheath Cup Cell Transplantation in Male and Female Pattern Hair Loss: A Single‐Arm, Multi‐Center, Phase III Equivalent Clinical Study”

January 2026 in “The Journal of Dermatology”

research Wnt activator CHIR99021-stimulated human dermal papilla spheroids contribute to hair follicle formation and production of reconstituted follicle-enriched human skin

40 citations , June 2019 in “Biochemical and Biophysical Research Communications”

CHIR99021 helps create human skin with hair follicles, offering hope for hair loss treatments.

research Alteration of Skin Properties with Autologous Dermal Fibroblasts

67 citations , May 2014 in “International Journal of Molecular Sciences”

Using your own skin cells can help repair aging skin and promote hair growth.

research Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege

53 citations , September 2013 in “Journal of Investigative Dermatology”

Hair follicle cells help protect against immune attacks by regulating T-cell activity.

research Cell Movement in the Hair Follicle Dermis – More Than a Two-Way Street?

47 citations , December 2003 in “Journal of Investigative Dermatology”

DS cells in hair follicles can help form and restore hair, especially in hair loss conditions.

research Niche formed by bone morphogenetic protein antagonists gremlin 1 and gremlin 2 in human hair follicles

5 citations , January 2022 in “Health Science Reports”

Gremlin proteins help regulate hair growth by balancing signals in hair follicles.

research Cell-based treatments for hair loss: research update on “hair cloning”

2 citations , March 2013 in “Hair transplant forum international”

Research on "hair cloning" for hair loss shows potential for hair thickening but has not yet achieved new hair growth in humans.

research 551 Combining Laser Capture Microdissection and RNAseq Analysis to Generate a Human Anagen Hair Follicle Transcriptome Atlas

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Researchers made a detailed map of gene activity for different parts of human hair follicles to help create targeted hair disorder treatments.

research Hair Physiology (Hair Growth, Alopecia, Scalp Treatment, etc.)

1 citations , January 2017 in “Elsevier eBooks”

The document concludes that new treatments for hair loss may involve a combination of cosmetics, clinical methods, and genetic approaches.

research 282 WITHDRAWN

September 2017 in “Journal of Investigative Dermatology”

HIF-1A may aid hair growth, Backhousia citriodora improves skin, autologous cells stabilize hair loss, infrared thermography assesses alopecia, and a new treatment preserves hair.

Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

208 citations , December 2003 in “Journal of Investigative Dermatology”

Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.

research Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type

184 citations , November 2014 in “Developmental Cell”

Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.

research Age-Related Changes in Female Scalp Dermal Sheath and Dermal Fibroblasts: How the Hair Follicle Environment Impacts Hair Aging

14 citations , December 2020 in “Journal of Investigative Dermatology”

Aging causes changes in the scalp that can affect hair growth and lead to older-looking hair in women.

research Single-Cell RNA Profiling of Human Skin Reveals Age-Related Loss of Dermal Sheath Cells and Their Contribution to a Juvenile Phenotype

37 citations , January 2022 in “Frontiers in Genetics”

Aging reduces dermal sheath cells, affecting youthful skin appearance.

research 022 Randomized, double-blind, placebo-controlled, single-centre, phase I safety study of intradermal injections of autologous fibroblasts isolated from the non-bulbar dermal sheath of the hair follicle to treat skin aging

September 2017 in “Journal of Investigative Dermatology”

RCS-01 is safe and may help rejuvenate aging skin.

research Understanding the functional contribution of dermal stem cells to hair follicle regeneration and skin wound healing

January 2017

Dermal stem cells help regenerate hair follicles and heal skin wounds.

research Hair matrix germinative epidermal cells confer follicle-inducing capabilities on dermal sheath and high passage papilla cells

61 citations , October 1996 in “Development”

Hair growth can be stimulated by combining certain skin cells, which can rejuvenate old cells and cause them to specialize in hair follicle creation.

MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

research miR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

18 citations , December 2020 in “Frontiers in cell and developmental biology”

miR-140-5p in certain cell vesicles helps hair growth by boosting cell proliferation.

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Related Terms

Research

research Autologous cell–based therapy for male and female pattern hair loss using dermal sheath cup cells: A randomized placebo-controlled double-blinded dose-finding clinical study

research Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles

research Differential Expression of CXCL12 in Human and Mouse Hair: Androgens Induce CXCL12 in Human Dermal Papilla and Dermal Sheath Cup

research Combatting ageing in dermal papilla cells and promoting hair follicle regeneration using exosomes from human hair follicle dermal sheath cup cells

research High migratory activity of dermal sheath cup cells associated with the clinical efficacy of autologous cell-based therapy for pattern hair loss

research Efficacy of autologous dermal sheath cup cell transplantation in male and female pattern hair loss: A Single‐Arm, Multi‐Center, phase III equivalent clinical study

research Changes in the Expression of Smooth Muscle Cell–Related Genes in Human Dermal Sheath Cup Cells Associated with the Treatment Outcome of Autologous Cell–Based Therapy for Male and Female Pattern Hair Loss

research Morphometric prediction of mesenchymal stromal cell-like immunosuppressive capacity of human hair follicle dermal sheath cup cells: an implication for regenerative medicine in hair loss diseases

research 281 Phase I/IIa clinical trial for the treatment of androgenetic alopecia using intradermal injections of cultured autologous dermal sheath cup cells

research Correction to “Efficacy of Autologous Dermal Sheath Cup Cell Transplantation in Male and Female Pattern Hair Loss: A Single‐Arm, Multi‐Center, Phase III Equivalent Clinical Study”

research Wnt activator CHIR99021-stimulated human dermal papilla spheroids contribute to hair follicle formation and production of reconstituted follicle-enriched human skin

research Alteration of Skin Properties with Autologous Dermal Fibroblasts

research Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege

research Cell Movement in the Hair Follicle Dermis – More Than a Two-Way Street?

research Niche formed by bone morphogenetic protein antagonists gremlin 1 and gremlin 2 in human hair follicles

research Cell-based treatments for hair loss: research update on “hair cloning”

research 551 Combining Laser Capture Microdissection and RNAseq Analysis to Generate a Human Anagen Hair Follicle Transcriptome Atlas

research Hair Physiology (Hair Growth, Alopecia, Scalp Treatment, etc.)

research 282 WITHDRAWN

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

research Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type

research Age-Related Changes in Female Scalp Dermal Sheath and Dermal Fibroblasts: How the Hair Follicle Environment Impacts Hair Aging

research Single-Cell RNA Profiling of Human Skin Reveals Age-Related Loss of Dermal Sheath Cells and Their Contribution to a Juvenile Phenotype

research 022 Randomized, double-blind, placebo-controlled, single-centre, phase I safety study of intradermal injections of autologous fibroblasts isolated from the non-bulbar dermal sheath of the hair follicle to treat skin aging

research Single-Cell Proteomics Uncovers Dual Traits of Dermal Sheath Cells in Wound Repair

research Exploring the Role of Dermal Sheath Cells in Wound Healing and Fibrosis

research Dermal Sheath Cells and Hair Follicle Regeneration

research Understanding the functional contribution of dermal stem cells to hair follicle regeneration and skin wound healing

research Hair matrix germinative epidermal cells confer follicle-inducing capabilities on dermal sheath and high passage papilla cells

research miR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells