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Increased ODC activity leads to skin tumors by recruiting stem cells, not by toxic byproducts.

Dsg1 is essential for maintaining a healthy skin barrier in mice.

Epristeride's metabolism in zebrafish helps improve doping detection methods.

A person got uncombable hair syndrome from two copies of chromosome 1 from their mother.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

A patient with a PLEC mutation has epidermolysis bullosa, muscular dystrophy, and myasthenia gravis, which improved with steroid treatment.

PINCH-1 is crucial for skin cell adhesion and movement, working with EPLIN and ILK.

Genetic mutations that disrupt homocysteine breakdown lead to increased damage in mouse hair keratin.

Hydrophilic carbon dots cause one protein to clump more and prevent another from clumping.

Deleting part of a gene in mice causes wavy hair and high pup loss.

Deleting the scd1 gene in mice prevents obesity by disrupting skin lipids and improving heat regulation.

Some mutant mice have hair with abnormal cross-linking, mainly in the cuticle, not affecting other hair parts.

A woman with inflammatory bowel disease improved after treatment with ustekinumab for a rare skin condition associated with her disease.

Two patients had a unique form of trichothiodystrophy with reduced high-sulfur proteins in their hair.

Secukinumab reduces immune activity in hidradenitis suppurativa skin.

Promising treatments for EBS include anti-inflammatory drugs, antibiotics, creams, mTOR inhibitors, and gene editing, but more trials are needed.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

Scientists successfully purified a protein called Wnt3a, which is involved in processes like hair growth, but the overall yield was low, suggesting more work is needed to improve this.

VDUP1 is found in skin and hair follicles, interacts with sciellin, and may help regulate skin cell differentiation.

A variant in the ADAM17 gene causes hair loss by increasing protein degradation through TRIM47.

Key enzymes control androgen levels, affecting hormone activity and potential treatments.

Mice without certain skin enzymes have faster hair growth and bigger eye glands.

The enzyme system in hair follicles is similar to the liver's and is affected by certain inhibitors.

Defective protein folding due to a mutation is key in ANE syndrome.

Upadacitinib can cause hypersensitivity that worsens ulcerative colitis symptoms.

Deleting MED1 in skin cells causes hair loss and skin changes.

Most Recessive Dystrophic Epidermolysis Bullosa patients with a specific mutation likely have Sephardic ancestry from about 500 years ago.

The tumor suppressor BRCA2 helps in cell division by bringing key proteins to the area where cells split.

The enzyme DHHC13 is essential for healthy hair and skin, and its deficiency leads to hair loss and skin problems.

Blocking BACE1 and BACE2 enzymes causes hair color loss in mice.