research Sulforaphane promotes murine hair growth by accelerating the degradation of dihydrotestosterone
Sulforaphane may help with hair growth by breaking down a hormone that causes hair loss.
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research Identification of androgen-regulated genes in SV40-transformed human hair dermal papilla cells
Hsc70 protein may influence hair growth by responding to androgens.
research Androgen regulation of a specific gene in hamster flank organs
Male hormones control a specific gene in hamster skin, with different hormones having varying effects.
research Intracrine Testosterone Activation in Human Pancreatic β-Cells Stimulates Insulin Secretion
Testosterone helps human pancreatic cells increase insulin release.
research Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors
Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.
research The effects of oestrogens on linear bone growth
Estrogens are key for bone growth spurts in both boys and girls and affect growth into adulthood.
research Predominant expression of 5 alpha-reductase type 1 in pubic skin from normal subjects and hirsute patients.
The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.
research Androgenetic alopecia: effects of oral finasteride on hormone profile, reproduction and sexual function
Finasteride safely treats hair loss without harming hormones or reproduction, but may slightly reduce sexual function.
research Androgenetic alopecia may be associated with weaker COVID-19 T-cell immune response: An insight into a potential COVID-19 vaccine booster
Hair loss may link to weaker COVID-19 immunity, suggesting possible need for extra vaccine boost.
research Transcriptomic profiling in Silurana tropicalis testes exposed to finasteride
Finasteride affects frog testes by increasing testosterone, decreasing 5α-DHT, and impacting genes related to reproduction and other functions.
research The differences between aromatizable and non-aromatizable androgens in relation to body composition and metabolic syndrome risk factors in men
Testosterone and dihydrotestosterone have similar effects on body composition and metabolic health in men.
research Effects of In Utero Exposure to D-004, a Lipid Extract from Roystonea regia Fruits, in the Male Rat: A Comparison with Finasteride
D-004 may be a natural alternative to finasteride for treating enlarged prostate and male baldness.
research Big head? Bald head! Skull expansion: alternative model for the primary mechanism of AGA
The paper suggests that hair loss might be caused by skull growth, not just DHT's effect on hair follicles, and calls for more research.
research In-vivo uptake and metabolism of testosterone by the skin and other tissues of the rat
Rat skin takes up and processes testosterone differently than other organs, with testosterone being more important for the skin than its metabolite 5α-DHT.
![Synthesis, Biological Evaluation, and Molecular Docking of 4-Amino-2H-benzo[h]chromen-2-one Analogs Containing the Piperazine Moiety](/images/research/2ecf4eed-7dbe-4f1a-83db-739625546cdd/small/31808.jpg)
research Synthesis, biological evaluation and molecular docking of 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs containing the piperazine moiety
Analog 23 is a promising compound for prostate cancer treatment.
research Anti-inflammatory and anti-hyperplastic effect of Bazhengsan in a male rat model of chronic nonbacterial prostatitis
Bazhengsan reduces inflammation and tissue growth in chronic prostatitis.
research Bone density is normal in male rats treated with finasteride
Finasteride doesn't affect bone density in male rats.
research Androgen Receptor–Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia
Male pattern baldness is linked to higher levels of a certain receptor in the scalp, which leads to the shrinking of blood vessels and hair loss. Early treatment targeting this receptor could be more effective.
research The Postnatal Offspring of Finasteride-Treated Male Rats Shows Hyperglycaemia, Elevated Hepatic Glycogen Storage and Altered GLUT2, IR, and AR Expression in the Liver
Finasteride-treated male rats' offspring had altered glucose metabolism, potentially increasing diabetes risk.
research Androgens downregulate BMP2 impairing the inductive role of dermal papilla cells on hair follicle stem cells differentiation
Androgens reduce BMP2, which weakens the ability of certain cells to help hair stem cells become different types of cells.
research UPDATE ON IDIOPATHIC HIRSUTISM: DIAGNOSIS AND TREATMENT
The document concludes that combination therapy is most effective for treating excessive hair growth in women with idiopathic hirsutism, and more research is needed to understand the condition.
research Additive in vivo growth-inhibitory effects of flutamide and finasteride on androgen-sensitive Shionogi 115 carcinoma
Combining flutamide and finasteride can reduce prostate weight and tumor growth, potentially benefiting treatments needing optimal DHT inhibition.
research Effects of Hura crepitans and Its Active Ingredient, Daphne Factor F3, on Dihydrotestosterone-Induced Neurotrophin-4 Activation and Hair Retardation
Hura crepitans and its compound daphne factor F3 may help treat hair loss by blocking a specific hair growth inhibitor.
research Finasteride as a potential tool to improve Mesenchymal stem cell transplantation for myocardial infarction
Finasteride may improve stem cell therapy for heart attacks by increasing cell survival.
research Paxillin regulates androgen receptor expression associated with granulosa cell focal adhesions
Paxillin may help manage androgen-related disorders like PCOS by stabilizing androgen receptor proteins.
research Mechanism of androgenic alopecia: Addressing speculations through empirical evidences
Hair loss in men is mainly caused by hormones and genes, and while current treatments can slow it down, they can't fully stop it.
research Bad Hair Day: Testosterone and Wnts
Testosterone can both promote hair growth and cause baldness by affecting hair growth signals.
research Clinical use of 5α-reductase inhibitors
Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.
research FINASTERIDE INHIBITS 5?-REDUCTASE ACTIVITY IN HUMAN DERMAL FIBROBLASTS: PREDICTION OF ITS THERAPEUTIC APPLICATION IN ANDROGEN-RELATED SKIN DISEASES
Finasteride helps treat skin issues like acne and baldness by blocking testosterone conversion.
research Abstract P5-09-21: Selective androgen receptor modulators (SARMs): Enobosarm as targeted therapy for the treatment of androgen receptor-positive breast cancer
Enobosarm may effectively treat androgen receptor-positive breast cancer with fewer side effects.