7 citations
,
April 2019 in “The Journal of Steroid Biochemistry and Molecular Biology” 11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.
47 citations
,
June 2009 in “Journal of Biological Chemistry” Finasteride helps treat hair loss and prostate enlargement by blocking a specific enzyme.
September 2023 in “Biology of reproduction” New testosterone analogs show promise for male contraception with better activity and potentially fewer side effects.
37 citations
,
September 2018 in “Psychoneuroendocrinology” Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.
January 2014 in “HAL (Le Centre pour la Communication Scientifique Directe)” Sex hormones affect dog skin conditions, but more data is needed.
18 citations
,
November 2007 in “Annals of Surgery” Finasteride reduces inflammation and improves immune response after trauma by altering hormone levels.
7 citations
,
January 1994 in “Annual Reports in Medicinal Chemistry” Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.
28 citations
,
May 2018 in “Scientific reports” Exercise improves insulin sensitivity and hormone regulation in PCOS rats.
2 citations
,
January 2011 in “Clinical medicine insights” Dutasteride is effective for treating prostate enlargement and reducing related surgery risk, but is not approved for preventing prostate cancer.
27 citations
,
September 1999 in “Journal of Investigative Dermatology” Human skin cells contain Protease Nexin-1, and male hormones can decrease its levels, potentially affecting hair growth.
December 2016 in “University of Birmingham Institutional Research Archive (University of Birmingham)” Steroid-producing capabilities in certain cancers may contribute to treatment resistance.
33 citations
,
August 2018 in “Facial Plastic Surgery Clinics of North America” The document explains hair biology, the causes of hair loss, and reviews various hair loss treatments.
54 citations
,
February 1993 in “Endocrine reviews” Androgen conjugates might be better indicators of skin sensitivity to hormones in women with excessive hair growth.
47 citations
,
August 2016 in “Fitoterapia” Some herbs and their components might help treat hair loss by affecting various biological pathways, but more research and regulation are needed.
22 citations
,
October 2019 in “Cerebral cortex” Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.
16 citations
,
June 2008 in “Springer eBooks” Over 50% of women over 50 experience hair loss, with minoxidil being the only proven effective treatment.
15 citations
,
April 2008 in “Steroids” The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.
11 citations
,
September 2021 in “Journal of molecular endocrinology” ERβ has potential in treating prostate cancer and neurodegenerative diseases, but human studies are needed before clinical use.
10 citations
,
February 2009 in “European urology. Supplement” Treatment for benign prostatic hyperplasia involves drugs that either quickly relieve symptoms or reduce prostate size, with a combination offering more benefits but more side effects.
6 citations
,
March 2014 in “Herba Polonica” Plant extracts may help treat hormone-related hair loss.
5 citations
,
July 2000 in “Southern Medical Journal” Male pattern baldness is often genetic and linked to a hormone, with treatments like finasteride and minoxidil being effective for some men.
3 citations
,
October 2011 in “QJM” The drugs finasteride and dutasteride reduce low-grade prostate cancers but may double the risk of high-grade cancers.
November 1999 in “Journal of Cutaneous Medicine and Surgery” Treatments for hair loss include hormone modifiers, minoxidil, and hair transplant surgery.
59 citations
,
May 2014 in “Expert Opinion on Therapeutic Targets” The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.
10 citations
,
December 1995 in “Journal of women's health” Finasteride reduces hair growth in women with hirsutism and works better with electrolysis.
8 citations
,
April 2020 in “Facial Plastic Surgery Clinics of North America” Minoxidil, finasteride, and low-level laser light therapy are effective FDA-approved treatments for hair loss.
December 2023 in “Annals of phytomedicine” Dutasteride is more effective than finasteride for hair loss treatment.
July 2007 in “Journal of Reproduction & Infertility” Short-term finasteride use likely doesn't harm male fertility.
June 2013 in “Expert Review of Dermatology” The article concludes that hormonal therapy is an effective long-term acne treatment, even for those without hormonal imbalances.
22 citations
,
May 1999 in “International Journal of Dermatology” Hair loss from genetics and hormones can be treated with drugs or surgery.