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Two new enzymes, PAD-R11 and PAD-R4, were cloned and showed activity, with PAD-R11 resembling epidermal enzymes.

PAD type III enzyme is specific to rat skin and hair follicles.

PDI helps restore over-bleached hair's strength and structure by attaching special peptides.

PAD3 plays a key role in hair and skin protein structure and may be linked to skin diseases.

Peptide drugs now target hard-to-reach proteins more effectively and specifically.

Papain from papaya may help treat cardiovascular diseases by breaking down fibrin.

DPP may help hair regrowth by improving blood vessel function under stress.

Near-infrared probes can safely and effectively image cysteine protease activity for disease diagnosis.

Two peptides, RMYYY and VMYMI, may be effective anti-inflammatory drugs.

Targeting the PGI2 pathway may help heal diabetic foot ulcers.

Cadd4 effectively reduces cholesterol levels without side effects.

2h-ICPR can help screen for insulin antibodies in type 2 diabetes patients.

Trichohyalin and peptidylarginine deiminase type III are found together in rat hair follicles, with trichohyalin being modified after expression.

Blocking DPP4 can help activate hair growth and improve hair regeneration.

The study found a specific peptide that helps detect TGase 3 activity in skin and hair follicles.

RPGRIP1L helps skin cells stick together by blocking PKCβII, which can prevent skin blistering like in pemphigus.

Treprostinil, a drug, can delay wound healing in healthy cells but doesn't affect diabetic foot ulcer cells, suggesting further research could help understand its role in treating these ulcers.

Self-assembling peptide hydrogels effectively deliver drugs locally, enhancing treatment and reducing side effects.

Pegylated interferon-alpha 2a can cause a rare nerve disorder, but early treatment can lead to full recovery.

New pyridine compounds effectively inhibit GSK3, a diabetes treatment target.

Mutations in the enzyme don't significantly change how it binds to its specific substances.

Targeted protein degraders show promise in treating cancer but need to target more diverse proteins.

PAD enzymes play a key role in hair growth and structure.

BIVV009 is a safe treatment for bullous pemphigoid that reduces C3 deposition without harmful side effects.

PDE inhibitors, especially PDE4 inhibitors like apremilast, are effective for certain inflammatory skin conditions but have side effects and can be costly.

A potential treatment for atopic dermatitis could be to increase PADI1 expression to improve skin barrier function.

Phospholipids help plant proteins move by regulating receptor interactions.

Vitamin D boosts a specific gene activity in kidney cells that could improve heart and kidney function.

PEVIII is a promising treatment for Pseudomonas aeruginosa keratitis.

Diphencyprone initially increases mouse hair growth, then slows it, possibly due to changes in specific protein levels.